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Intermittent theta burst stimulation to the left dorsolateral prefrontal cortex improves working memory of subjects with methamphetamine use disorder

Published online by Cambridge University Press:  27 October 2021

Yi Zhang ,
Yixuan Ku ,
Junfeng Sun ,
Zafiris J. Daskalakis  and
Ti-Fei Yuan
Yi Zhang
Affiliation:
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China
Yixuan Ku
Affiliation:
Center for Brain and Mental Well-being, Department of Psychology, Sun Yat-sen University, Guangzhou, China
Junfeng Sun
Affiliation:
School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China
Zafiris J. Daskalakis*
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
Ti-Fei Yuan*
Affiliation:
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China
*
Authors for correspondence: Ti-Fei Yuan, E-mail: ytf0707@126.com, Zafiris Daskalakis, E-mail: zdaskalakis@health.ucsd.edu
Authors for correspondence: Ti-Fei Yuan, E-mail: ytf0707@126.com, Zafiris Daskalakis, E-mail: zdaskalakis@health.ucsd.edu
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Abstract

Background

Repetitive transcranial magnetic stimulation has been employed to treat drug dependence, reduce drug use and improve cognition. The aim of the study was to analyze the effectiveness of intermittent theta-burst stimulation (iTBS) on cognition in individuals with methamphetamine use disorder (MUD).

Methods

This was a secondary analysis of 40 MUD subjects receiving left dorsolateral prefrontal cortex (L-DLPFC) iTBS or sham iTBS for 20 times over 10 days (twice-daily). Changes in working memory (WM) accuracy, reaction time, and sensitivity index were analyzed before and after active and sham rTMS treatment. Resting-state EEG was also acquired to identify potential biological changes that may relate to any cognitive improvement.

Results

The results showed that iTBS increased WM accuracy and discrimination ability, and improved reaction time relative to sham iTBS. iTBS also reduced resting-state delta power over the left prefrontal region. This reduction in resting-state delta power correlated with the changes in WM.

Conclusions

Prefrontal iTBS may enhance WM performance in MUD subjects. iTBS induced resting EEG changes raising the possibility that such findings may represent a biological target of iTBS treatment response.

Keywords

DeltaEEG powerintermittent theta-burst stimulationmethamphetamine use disorderworking memory
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 6 , April 2023 , pp. 2427 - 2436
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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