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Fronto-parietal white matter microstructural deficits are linked to performance IQ in a first-episode schizophrenia Han Chinese sample

  • Q. Wang (a1), C. Cheung (a2), W. Deng (a1), M. Li (a1), C. Huang (a1), X. Ma (a1) (a3), Y. Wang (a1) (a3), L. Jiang (a1), G. McAlonan (a4), P. Sham (a2), D. A. Collier (a5), Q. Gong (a6), S. E. Chua (a2) and T. Li (a1) (a3)...

Abstract

Background

Evidence shows that cognitive deficits and white matter (WM) dysconnectivity can independently be associated with clinical manifestations in schizophrenia. It is important to explore this triadic relationship in order to investigate whether the triplet could serve as potential extended endophenotypes of schizophrenia.

Method

Diffusion tensor images and clinical performances were evaluated in 122 individuals with first-episode schizophrenia and 122 age- and gender-matched controls. In addition, 65 of 122 of the patient group and 40 of 122 controls were measured using intelligence quotient (IQ) testing.

Results

The schizophrenia group showed lower fractional anisotropy (FA) values than controls in the right cerebral frontal lobar sub-gyral (RFSG) WM. The schizophrenia group also showed a significant positive correlation between FA in the RFSG and performance IQ (PIQ); in turn, their PIQ score showed a significant negative correlation with negative syndromes.

Conclusions

Overall, these findings support the hypothesis that WM deficits may be a core deficit that contributes to cognitive deficits as well as to negative symptoms.

Copyright

Corresponding author

*Address for correspondence: T. Li, Ph.D., M.D., 20#, Dian Xun Nan Jie, Chengdu, Sichuan Province, People's Republic of China, 610041. (Email: xuntao26@hotmail.com)

References

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Annett, M (1970). A classification of hand preference by association analysis. British Journal of Psychology 61, 303321.
Ashburner, J, Friston, KJ (2005). Unified segmentation. Neuroimage 26, 839851.
Bishop, SJ, Fossella, J, Croucher, CJ, Duncan, J (2008). COMT Val158Met genotype affects recruitment of neural mechanisms supporting fluid intelligence. Cerebral Cortex 18, 21322140.
Camchong, J, Macdonald, AW 3rd, Bell, C, Mueller, BA, Lim, KO (2011). Altered functional and anatomical connectivity in schizophrenia. Schizophrenia Bulletin 37, 640650.
Cavanna, AE, Trimble, MR (2006). The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129, 564583.
Cheung, V, Cheung, C, McAlonan, GM, Deng, Y, Wong, JG, Yip, L, Tai, KS, Khong, PL, Sham, P, Chua, SE (2008). A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia. Psychological Medicine 38, 877885.
Cheung, V, Chiu, CPY, Law, CW, Cheung, C, Hui, CLM, Chan, KKS, Sham, PC, Deng, MY, Tai, KS, Khong, PL, McAlonan, GM, Chua, SE, Chen, E (2010). Positive symptoms and white matter microstructure in never-medicated first episode schizophrenia. Psychological Medicine 41, 17091719.
Falkai, P, Honer, WG, David, S, Bogerts, B, Majtenyi, C, Bayer, TA (1999). No evidence for astrogliosis in brains of schizophrenic patients. A post-mortem study. Neuropathology and Applied Neurobiology 25, 4853.
Firbank, MJ, Harrison, RM, Williams, ED, Coulthard, A (2000). Quality assurance for MRI: practical experience. British Journal of Radiology 73, 376383.
Flint, J, Munafo, MR (2007). The endophenotype concept in psychiatric genetics. Psychological Medicine 37, 163180.
Friston, KJ, Frith, CD (1995). Schizophrenia: a disconnection syndrome? Clinical Neuroscience 3, 8997.
Foong, J, Maier, M, Clark, CA, Barker, GJ, Miller, DH, Ron, MA (2000). Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study. Journal of Neurology, Neurosurgery & Psychiatry 68, 242244.
Fujiwara, H, Namiki, C, Hirao, K, Miyata, J, Shimizu, M, Fukuyama, H, Sawamoto, N, Hayashi, T, Murai, T (2007). Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: a diffusion tensor imaging study. Schizophrenia Research 95, 215222.
Gong, QY, Sluming, V, Mayes, A, Keller, S, Barrick, T, Cezayirli, E, Roberts, N (2005). Voxel-based morphometry and stereology provide convergent evidence of the importance of medial prefrontal cortex for fluid intelligence in healthy adults. Neuroimage 25, 11751186.
Gottesman, II, Gould, TD (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. American Journal of Psychiatry 160, 636645.
Gray, JR, Chabris, CF, Braver, TS (2003). Neural mechanisms of general fluid intelligence. Nature Neuroscience 6, 316322.
Greicius, MD, Supekar, K, Menon, V, Dougherty, RF (2009). Resting-state functional connectivity reflects structural connectivity in the default mode network. Cerebral Cortex 19, 7278.
Harrison, PJ, Weinberger, DR (2005). Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Molecular Psychiatry 10, 4068.
Harvey, PD, Green, MF, Bowie, C, Loebel, A (2006). The dimensions of clinical and cognitive change in schizophrenia: evidence for independence of improvements. Psychopharmacology 187, 356363.
Ho, BC, Milev, P, O'Leary, DS, Librant, A, Andreasen, NC, Wassink, TH (2006). Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Archives of General Psychiatry 63, 731740.
Hubl, D, Koenig, T, Strik, W, Federspiel, A, Kreis, R, Boesch, C, Maier, SE, Schroth, G, Lovblad, K, Dierks, T (2004). Pathways that make voices: white matter changes in auditory hallucinations. Archives of General Psychiatry 61, 658668.
Jia, Z, Huang, X, Wu, Q, Zhang, T, Lui, S, Zhang, J, Amatya, N, Kuang, W, Chan, RC, Kemp, GJ, Mechelli, A, Gong, Q (2010). High-field magnetic resonance imaging of suicidality in patients with major depressive disorder. American Journal of Psychiatry 167, 13811390.
Kay, SR, Fiszbein, A, Opler, LA (1987). The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261276.
Kim, DI, Mathalon, DH, Ford, JM, Mannell, M, Turner, JA, Brown, GG, Belger, A, Gollub, R, Lauriello, J, Wible, C, O'Leary, D, Lim, K, Toga, A, Potkin, SG, Birn, F, Calhoun, VD (2009). Auditory oddball deficits in schizophrenia: an independent component analysis of the fMRI multisite function BIRN study. Schizophrenia Bulletin 35, 6781.
Kubicki, M, McCarley, R, Westin, CF, Park, HJ, Maier, S, Kikinis, R, Jolesz, FA, Shenton, ME (2007). A review of diffusion tensor imaging studies in schizophrenia. Journal of Psychiatry Research 41, 1530.
Kyriakopoulos, M, Vyas, NS, Barker, GJ, Chitnis, XA, Frangou, S (2008). A diffusion tensor imaging study of white matter in early-onset schizophrenia. Biological Psychiatry 63, 519523.
Lee, K, Yoshida, T, Kubicki, M, Bouix, S, Westin, CF, Kindlmann, G, Niznikiewicz, M, Cohen, A, McCarley, RW, Shenton, ME (2009). Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a diffusion tensor imaging study. Schizophrenia Research 108, 3340.
Liu, Y, Liang, M, Zhou, Y, He, Y, Hao, Y, Song, M, Yu, C, Liu, H, Liu, Z, Jiang, T (2008). Disrupted small-world networks in schizophrenia. Brain 131, 945961.
Michael, AM, Calhoun, VD, Pearlson, GD, Baum, SA, Caprihan, A (2008). Correlations of diffusion tensor imaging values and symptom scores in patients with schizophrenia. Conference Proceedings: IEEE Engineering in Medicine and Biology Society 2008, 54945497.
Minami, T, Nobuhara, K, Okugawa, G, Takase, K, Yoshida, T, Sawada, S, Ha-Kawa, S, Ikeda, K, Kinoshita, T (2003). Diffusion tensor magnetic resonance imaging of disruption of regional white matter in schizophrenia. Neuropsychobiology 47, 141145.
Nestor, PG, Kubicki, M, Nakamura, M, Niznikiewicz, M, McCarley, RW, Shenton, ME (2010). Comparing prefrontal gray and white matter contributions to intelligence and decision making in schizophrenia and healthy controls. Neuropsychology 24, 121129.
Nestor, PG, Kubicki, M, Spencer, KM, Niznikiewicz, M, McCarley, RW, Shenton, ME (2007). Attentional networks and cingulum bundle in chronic schizophrenia. Schizophrenia Research 90, 308315.
Phillips, OR, Nuechterlein, KH, Clark, KA, Hamilton, LS, Asarnow, RF, Hageman, NS, Toga, AW, Narr, KL (2009). Fiber tractography reveals disruption of temporal lobe white matter tracts in schizophrenia. Schizophrenia Research 107, 3038.
Prasad, KM, Keshavan, MS (2008). Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct ‘extended endophenotypes’? Schizophrenia Bulletin 34, 774790.
Rotarska-Jagiela, A, Oertel-Knoechel, V, DeMartino, F, van de Ven, V, Formisano, E, Roebroeck, A, Rami, A, Schoenmeyer, R, Haenschel, C, Hendler, T, Maurer, K, Vogeley, K, Linden, DE (2009). Anatomical brain connectivity and positive symptoms of schizophrenia: a diffusion tensor imaging study. Psychiatry Research 174, 916.
Schopp, LH, Callahan, CD, Johnstone, B, Schwake, CJ (1998). Utility of a seven-subtest version of the WAIS-R among an Alzheimer's disease sample. Archives of Clinical Neuropsychology 13, 637643.
Shenton, ME, Dickey, CC, Frumin, M, McCarley, RW (2001). A review of MRI findings in schizophrenia. Schizophrenia Research 49, 152.
Shergill, SS, Kanaan, RA, Chitnis, XA, O'Daly, O, Jones, DK, Frangou, S, Williams, SC, Howard, RJ, Barker, GJ, Murray, RM, McGuire, P (2007). A diffusion tensor imaging study of fasciculi in schizophrenia. American Journal of Psychiatry 164, 467473.
Shin, YW, Kwon, JS, Ha, TH, Park, HJ, Kim, DJ, Hong, SB, Moon, WJ, Lee, JM, Kim, IY, Kim, SI, Chung, EC (2006). Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients. Neuroimage 30, 12851291.
Skelly, LR, Calhoun, V, Meda, SA, Kim, J, Mathalon, DH, Pearlson, GD (2008). Diffusion tensor imaging in schizophrenia: relationship to symptoms. Schizophrenia Research 98, 157162.
Ventura, J, Hellemann, GS, Thames, AD, Koellner, V, Nuechterlein, KH (2009). Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophrenia Research 113, 189199.
Wechsler, D (1999). WAIS-R Manual: Wechsler Adult Intelligence Scale – Revised. Psychological Corporation: San Antonio, TX.

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