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Endothelial dysfunction is associated with a greater depressive symptom score in a general elderly population: the Hoorn Study

Published online by Cambridge University Press:  13 August 2013

T. T. van Sloten ,
M. T. Schram ,
M. C. Adriaanse ,
J. M. Dekker ,
G. Nijpels ,
T. Teerlink ,
P. G. Scheffer ,
F. Pouwer ,
C. G. Schalkwijk  and
C. D. A. Stehouwer
...Show all authors
T. T. van Sloten
Affiliation:
Department of Medicine, Maastricht University Medical Centre, The Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, The Netherlands
M. T. Schram
Affiliation:
Department of Medicine, Maastricht University Medical Centre, The Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands
M. C. Adriaanse
Affiliation:
EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands
J. M. Dekker
Affiliation:
EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands
G. Nijpels
Affiliation:
EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands
T. Teerlink
Affiliation:
Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
P. G. Scheffer
Affiliation:
Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
F. Pouwer
Affiliation:
Centre of Research on Psychology in Somatic Diseases, Department of Medical Psychology and Neuropsychology, Tilburg University, The Netherlands
C. G. Schalkwijk
Affiliation:
Department of Medicine, Maastricht University Medical Centre, The Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands
C. D. A. Stehouwer
Affiliation:
Department of Medicine, Maastricht University Medical Centre, The Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, The Netherlands
R. M. A. Henry*
Affiliation:
Department of Medicine, Maastricht University Medical Centre, The Netherlands Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands
*
*Address for correspondence: R. M. A. Henry, Ph.D., M.D., Department of Medicine, Maastricht University Medical Centre, Prof. Debyelaan 25, 6229 HX Maastricht, The Netherlands. (Email: rma.henry@mumc.nl)
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Abstract

Background

Endothelial dysfunction (ED), low-grade inflammation (LGI) and oxidative stress (OxS) may be involved in the pathobiology of depression. Previous studies on the association of these processes in depression have yielded contradictory results. We therefore investigated comprehensively, in a population-based cohort study, the association between ED, LGI and OxS on the one hand and depressive symptoms on the other.

Method

We used data from the Hoorn Study and determined biomarkers of ED [flow-mediated dilatation (FMD), von Willebrand factor, soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1, soluble thrombomodulin and soluble endothelial selectin], LGI [C-reactive protein, tumour necrosis factor-α, interleukin 6, interleukin 8, serum amyloid A, myeloperoxidase (MPO) and sICAM-1] and OxS (oxidized low density lipoprotein and MPO). Depressive symptoms were quantified by the Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire (n = 493; age 68 years; 49.9% female). Regression analyses were performed with the use of biomarker Z scores. Adjustments were made for age, sex and glucose metabolism status (cohort stratification variables) and prior cardiovascular disease, hypertension, waist-to-hip ratio, cholesterol levels, education level, physical activity, dietary habits, and the use of antihypertensive and/or lipid-lowering medication and/or metformin (potential confounders).

Results

After adjustment for age, sex and glucose metabolism status, one standard deviation increase in the ED Z score was associated with a 1.9 [95% confidence interval (CI) 0.7–3.1] higher CES-D score. Additional adjustments did not materially change this result. LGI and OxS were not associated with the CES-D score.

Conclusions

ED, as quantified by an array of circulating biomarkers and FMD, was independently associated with depressive symptoms. This study supports the hypothesis that ED plays an important role in the pathobiology of depression.

Keywords

Depressionendothelial dysfunctionlow-grade inflammationoxidative stress
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 7 , May 2014 , pp. 1403 - 1416
Copyright
Copyright © Cambridge University Press 2013 

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