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The effects of antipsychotics on brain structure: what have we learnt from structural imaging of schizophrenia?: A commentary on ‘Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings’ by Navari & Dazzan (2009)

  • S. J. Borgwardt (a1) (a2) (a3), R. Smieskova (a1) (a2), P. Fusar-Poli (a3), K. Bendfeldt (a2) and A. Riecher-Rössler (a1)...


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Corresponding author

*Address for correspondence: Dr S. J. Borgwardt, Psychiatric Outpatient Department, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. (Email:


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Borgwardt, SJ, McGuire, PK, Aston, J, Gschwandtner, U, Pfluger, MO, Stieglitz, RD, Radue, EW, Riecher-Rossler, A (2008). Reductions in frontal, temporal and parietal volume associated with the onset of psychosis. Schizophrenia Research 106, 108114.
DeLisi, LE (2008). Reviewing the ‘facts about schizophrenia’: a possible or impossible task? Schizophrenia Research 102, 1920.
Fusar-Poli, P, Perez, J, Broome, M, Borgwardt, S, Placentino, A, Caverzasi, E, Cortesi, M, Veggiotti, P, Politi, P, Barale, F, McGuire, P (2007). Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 31, 465484.
Job, DE, Whalley, HC, Johnstone, EC, Lawrie, SM (2005). Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage 25, 10231030.
Konopaske, GT, Dorph-Petersen, KA, Sweet, RA, Pierri, JN, Zhang, W, Sampson, AR, Lewis, DA (2008). Effect of chronic antipsychotic exposure on astrocyte and oligodendrocyte numbers in macaque monkeys. Biological Psychiatry 63, 759765.
Navari, S, Dazzan, P (2009). Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings. Psychological Medicine. Published online: 2 April 2009. doi:10.1017/S0033291709005315.
Pantelis, C, Velakoulis, D, McGorry, PD, Wood, SJ, Suckling, J, Phillips, LJ, Yung, AR, Bullmore, ET, Brewer, W, Soulsby, B, Desmond, P, McGuire, PK (2003). Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361, 281288.
Riecher-Rossler, A, Gschwandtner, U, Aston, J, Borgwardt, S, Drewe, M, Fuhr, P, Pfluger, M, Radu, W, Schindler, C, Stieglitz, RD (2007). The Basel early-detection-of-psychosis (FEPSY) study – design and preliminary results. Acta Psychiatrica Scandinavica 115, 114125.
Smieskova, R, Fusar-Poli, P, Allen, P, Bendfeldt, K, Stieglitz, RD, Drewe, J, Radu, EW, McGuire, PK, Riecher, A, Borgwardt, SJ (in press). The effects of antipsychotics on the brain: What have we learnt from structural neuroimaging of schizophrenia? – a systematic review. Current Pharmaceutical Design.
Wood, SJ, Pantelis, C, Velakoulis, D, Yucel, M, Fornito, A, McGorry, PD (2008). Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophrenia Bulletin 34, 322329.



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