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Disrupted prefrontal regulation of striatum-related craving in Internet gaming disorder revealed by dynamic causal modeling: results from a cue-reactivity task

Published online by Cambridge University Press:  27 February 2020

Guang-Heng Dong Open the ORCID record for Guang-Heng Dong [Opens in a new window] ,
Min Wang ,
Hui Zheng ,
Ziliang Wang ,
Xiaoxia Du  and
Marc N. Potenza
Guang-Heng Dong*
Affiliation:
Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang Province, PR China
Min Wang
Affiliation:
Center for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang Province, PR China
Hui Zheng
Affiliation:
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
Ziliang Wang
Affiliation:
School of Psychology, Beijing Normal University, Beijing10010, PR China
Xiaoxia Du
Affiliation:
Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, PR China
Marc N. Potenza
Affiliation:
Connecticut Mental Health Center, New Haven, CT, USA Connecticut Council on Problem Gambling, Wethersfield, CT, USA Department of Psychiatry, Department of Neurobiology, and Child Study Center, Yale University School of Medicine, New Haven, CT, USA
*
Author for correspondence: Guang-Heng Dong, E-mail: dongguangheng@hznu.edu.cn
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Abstract

Background

Studies of Internet gaming disorder (IGD) suggest an imbalanced relationship between cognitive control and reward processing in people with IGD. However, it remains unclear how these two systems interact with each other, and whether they could serve as neurobiological markers for IGD.

Methods

Fifty IGD subjects and matched individuals with recreational game use (RGU) were selected and compared when they were performing a cue-craving task. Regions of interests [anterior cingulate cortex (ACC), lentiform nucleus] were selected based on the comparison between brain responses to gaming-related cues and neutral cues. Directional connectivities among these brain regions were determined using Bayesian estimation. We additionally examined the posterior cingulate cortex (PCC) in a separate analysis based on data implicating the PCC in craving in addiction.

Results

During fixed-connectivity analyses, IGD subjects showed blunted ACC-to-lentiform and lentiform-to-ACC connectivity relative to RGU subjects, especially in the left hemisphere. When facing gaming cues, IGD subjects trended toward lower left-hemispheric modulatory effects in ACC-to-lentiform connectivity than RGU subjects. Self-reported cue-related craving prior to scanning correlated inversely with left-hemispheric modulatory effects in ACC-to-lentiform connectivity.

Conclusions

The results suggesting that prefrontal-to-lentiform connectivity is impaired in IGD provides a possible neurobiological mechanism for difficulties in controlling gaming-cue-elicited cravings. Reduced connectivity ACC-lentiform connectivity may be a useful neurobiological marker for IGD.

Keywords

Dynamic causal modeleffective connectivityexecutive controlInternet gaming disorder
Type
Original Articles
Information
Psychological Medicine , Volume 51 , Issue 9 , July 2021 , pp. 1549 - 1561
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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