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Cortical evoked potentials and clinical rating scales as measures of depressive illness

Published online by Cambridge University Press:  09 July 2009

H. Ashton ,
J. F. Golding ,
V. R. Marsh ,
J. W. Thompson ,
F. Hassanyeh  and
S. P. Tyrer
H. Ashton*
Affiliation:
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, and Department of Psychiatry, Royal Victoria Infirmary, Newcastle-upon-Tyne
J. F. Golding
Affiliation:
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, and Department of Psychiatry, Royal Victoria Infirmary, Newcastle-upon-Tyne
V. R. Marsh
Affiliation:
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, and Department of Psychiatry, Royal Victoria Infirmary, Newcastle-upon-Tyne
J. W. Thompson
Affiliation:
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, and Department of Psychiatry, Royal Victoria Infirmary, Newcastle-upon-Tyne
F. Hassanyeh
Affiliation:
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, and Department of Psychiatry, Royal Victoria Infirmary, Newcastle-upon-Tyne
S. P. Tyrer
Affiliation:
Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, and Department of Psychiatry, Royal Victoria Infirmary, Newcastle-upon-Tyne
*
1Address for correspondence: Dr H. Ashton, Clinical Psychopharmacology Unit, Department of Pharmacological Sciences, University of Newcastle-upon-Tyne, The Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH.
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Synopsis

Relationships between clinical ratings and cortical evoked potentials were examined before and during antidepressant drug treatment in 32 patients with major depressive disorder (DSM-III). Clinical rating scales included Hamilton Rating Scale for Depression, Beck Depression Inventory, Present State Examination (PSE) and Newcastle Scale. Evoked potentials included contingent negative variation (CNV), post-imperative negative variation (PINV) and auditory evoked potential (AEP) There were close correlations between all rating scales, and factor analysis produced only one component, suggesting that the common variance between them related to severity of depression. CNV magnitude before treatment correlated negatively with severity of depression regardless of diagnostic category. Depressed patients had a prominent PINV which persisted during antidepressant treatment. The amplitude of late components (N1P2) of the AEP was reduced strikingly in patients with a history of suicide attempts.

Type
Research Article
Information
Psychological Medicine , Volume 18 , Issue 2 , May 1988 , pp. 305 - 317
Copyright
Copyright © Cambridge University Press 1988

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References

Abou-Saleh, M. T. & Coppen, A. (1983). Classical ion of depression and response to antidepressive therapies. British Journal Psychiatry 143, 601–603.CrossRefGoogle Scholar
Aghajanian, G. K. (1982). Neurophysiological properties ofpsychotomimetics. In Psychotropic Agents Part III (ed. Hoffmeister, F. and Stille, R), pp 89–109. Springer-Verlag: Heidelberg.CrossRefGoogle Scholar
American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders (third edn), DSM-II. APA: Washington.Google Scholar
Anisman, H., Kokkinidis, L. & Sklar, L. S. (1981). Contribution of neurochemical charge to stress-induced behavoural deficits. In Theory in Psychopharmacology, Vol. I. (ed. Cooper, S. J.), pp. 65–102. Academic Press: London.Google Scholar
Ashton, H. (1987). Brain Systems, Disorders, and Psychotropic Drugs. Oxford University Press: Oxford.Google Scholar
Ashton, H., Millman, J. E., Telford, R. & Thompson, J. W. (1974). The effect of caffeine, nitrazepam and cigarette smoking on the contingent negative variation in man. Electroencephalography and Clinical Neurophysiology 37, 59–71.CrossRefGoogle ScholarPubMed
Ashton, H., Millman, J. E., Telford, R. & Thompson, J. W. (1978). A comparison of some physiological and psychological effects of Motival (fluphenazine and nortriptyline) and diazepam in normal subjects. British Journal of Clinical Pharmacology 5, 141–147.CrossRefGoogle ScholarPubMed
Ashton, H., Golding, J., Marsh, V. R., Millman, J. E. & Thompson, J. W. (1981). The seed and the soil: effect of dosage, personality and starting state on the response to δ9-tetrahydrocannabinol in man. British Journal of Clinical Pharmacology 12, 705–720.CrossRefGoogle ScholarPubMed
Bachneff, S. A. & Engelmann, F. (1980). Contingent negative variation, postimperative negative variation, and psychopathology. Biological Psychiatry 15, 323–328.Google ScholarPubMed
Bailey, J. & Coppen, A. (1976). A comparison between the Hamilton Rating Scale and the Beck Inventory in the measurement of depression. British Journal of Psychiatry 128, 486–489.CrossRefGoogle ScholarPubMed
Banki, C. H (1977). Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindolacetic acid in depressed women. Journal of Neurological Transmitters 41, 135–143.Google Scholar
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–571.CrossRefGoogle ScholarPubMed
Bolz, J., Giedke, H. & Heimann, H. (1979). GSR, AEP and CNV in depressed patients and healthy controls (1979). In Human Evoked Potentials - Applications and Problems (ed. Lehmann, D and Callaway, E.), p. 448. Plenum Press New York.Google Scholar
Bridges, P. K., Barlett, J. P. & Sepping, P. (1976). Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients. Psychological Medicine 6, 399–405.CrossRefGoogle ScholarPubMed
Buchsbaum, M. (1976). Self-regulation of stimulus intensity. Augmenting reducing and averaged evoked response. In Consciousness and Self-Regulation, Advances in Research, Vol. I. (ed. Schwartz, G. E. and Shapiro, D.), pp. 101–135. Plenum Press: New York.CrossRefGoogle Scholar
Buchsbaum, M. S. & Coppola, R. (1979). Signal-to-noise ratio and response variability in affective disorders and schizophrenia. In Evoked Potentials and Behavior (ed. Begleiter, H.), pp. 447–465. Plenum Press: New York.CrossRefGoogle Scholar
Buchsbaum, M. S., Goodwin, F., Murphy, D. & Borge, G. (1971) AER in affective disorders. American Journal of Psychiatry 128, 19–25.Google ScholarPubMed
Buchsbaum, M. S., Landau, S., Murphy, D. & Goodwin, F. (1973). Average evoked response in bipolar and unipolar affective disorders: relationship to sex, age of onset, and monoamine oxidase. Biological Psychiatry 7, 199–212.Google ScholarPubMed
Buchsbaum, M. S., Gerner, R. & Post, R. M. (1981). The effects of sleep deprivation on average evoked responses in depressed patients and normals. Biological Psychiatry 16, 351–363.Google ScholarPubMed
Carney, M. W. P., Roth, M. & Garside, R. T. (1965). The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry 111, 659–674.CrossRefGoogle Scholar
Chouinard, G., Annable, L & Dongier, M. (1977). Differences in psychopathology of schizophrenic patients with normal and abnormal postimperative negative variation (PINV). Comprehensive Psychiatry 18, 83–87.CrossRefGoogle ScholarPubMed
Cooper, R., Ossleton, J. W. & Shaw, J. C. (1980). EEG Technology (third edn). Butterworth: London.Google Scholar
Donald, M. W. (1980). Memory, learning and event-related potentials. In Motivation, Motorand Sensory Processes of the Brain. Progress in Brain Research, 54. (ed. Kornhuber, H. H. and Deecke, L.), pp. 615–627. Elsevier/North Holland Biomedical Press: Amsterdam.Google Scholar
Donchin, E., Ritter, W. & McCallum, W. C. (1978). Cognitive psychophysiology: endogenous components of the event-related potentials. In Event-Related Brain Potentials in Man (ed. Callaway, E., Tueting, P. and Koslow, S. H.), pp. 349–411. Academic Press: New York.CrossRefGoogle Scholar
Dongier, M. (1973). Clinical applications of the CNV. Event-related slow potentials of the brain; their relations to behaviour. Eteclroencephalography and Clinical Neurophyswlogy 35, Suppl. 33, 309–315Google Scholar
Dongier, M., Dubrovsky, B. & Engelmann, F. (1977). Event-related slow potentials in psychiatry. In Psychopathology and Brain Dysfunction (ed. Shagass, C.Gershon, S. and Friedhoff, A. J.), pp. 339–352. Raven Press: New York.Google Scholar
Edwards, B. C., Lambert, M. J., Maran, P. W., McCully, T., Smith, K. C. & Ellingson, A. G. (1984) A meta-analytic comparison of the Beck Depression Inventory and the Hamilton Rating Scale for Depression as measures of treatment outcome. British Journal of Clinical Psychology 23, 93–99.CrossRefGoogle ScholarPubMed
Fenton, G. W. (1984). The electroencephalogram in psychiatry: clinical and research applications. Psychiatric Developments 2, 53–75.Google ScholarPubMed
Friedmann, J., McCallum, P & Meares, R. (1980). Stimulus intensity control in depression: a study of the comparative effect of doxepin and amitriptyline on cortical evoked potentials. Australian and New Zealand Journal of Psychiatry 14, 115–119.CrossRefGoogle Scholar
Giedke, H. & Bolz, J. (1980). Pre- and postimperative negative variation (CNV and PINV) under different conditions of controllability in depressed patients and healthy controls. In Motivation, Motor and Sensory Processes of the Brain. Progress in Brain Research, 54. (ed. Kornhuber, H. H. and Deecke, L.), pp. 579–582. Elsevier/North Holland Biomedical Press: Amsterdam.Google Scholar
Giedke, H., Bolz, J. & Heimann, H. (1980 a). Evoked potentials, expectancy wave, and skin resistance in depressed patients and healthy controls. Pharmakopsychiatrie Neuro-psychopharmakologie 13, 91–101.CrossRefGoogle ScholarPubMed
Giedke, H., Bolz, J. & Heimann, H. (1980 b). Skin resistance variables, acoustically evoked potentials, and contingent negative variation in depressed patients and healthy controls. Arzneimer-Forschung/Drug Research 30 (11), 1197.Google Scholar
Golding, J. F., Ashton, C. H., Marsh, V. R. & Thompson, J. W. (1986 a). Early and late SEPs-the later the potential the greater the relevance to personality. Personality and Individual Differences 7, 787–794.CrossRefGoogle Scholar
Golding, J. F., Ashton, H., Marsh, R. & Thompson, J. W. (1986 b). Transcutaneous electrical nerve stimulation produces variable changes in somatosensory evoked potentials, sensory perception and pain threshold: clinical implications for pain relief. Journal of Neurology, Neurosurgery and Psychiatry 49, 1397–1406.CrossRefGoogle ScholarPubMed
Goodwin, F K. & Post, R. M. (1983). 5-hydroxytryptamine and depression: a model for the interaction of normal variance with pathology. British Journal of Clinical Pharmacology 15, 393–405CrossRefGoogle Scholar
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 56–62.CrossRefGoogle ScholarPubMed
Hamilton, M. (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278–296.CrossRefGoogle ScholarPubMed
Hillyard, S. A. & Picton, T. W. (1979). Event-related brain potentials and selective information processing in man. In Cognitive Components in Cerebral Event-Related Potentials and Selective Attention Progress in Clinical Neurophysiology Vol. 6 (ed. Desmedt, J. E.) pp. 1–52. Karger: Basel.Google Scholar
Holden, N. L. (1983). Depression and the Newcastle Scale: their relationship to the dexamethasone suppression test. British Journal of Psychiatry 142, 150–157.CrossRefGoogle Scholar
Irwin, D. A., Knott, J. R., McAdam, D. W. & Rebert, C. S. (1966). Motivational determinants of the ‘contingent negative variation’. Electroencephalography and Clinical Neurophysiology 21, 538–543.CrossRefGoogle ScholarPubMed
Lader, M. (1975). The Psychophysiology of Mental Illness. Routledge & Kegan Paul: London.Google Scholar
Low, M. D. & McSherryr, J W. (1968). Further observations of psychological factors involved in CNV genesis. Electroencephalography and Clinical Neurophysiology 25, 203–207.CrossRefGoogle ScholarPubMed
Low, M. D., Coats, A. C., Rettig, G. H. & McSherry, J. W. (1967). Anxiety, attentiveness-alertness; a phenomenological study of the CNV. Neuropsychologia 5, 379–384.CrossRefGoogle Scholar
McAdam, D. W., Irwin, D. A., Rebert, C. S. & Knott, J. R. (1966). Conative control of the contingent negative variation. Electroencephalography and Clinical Neurophysiology 21, 194–195.CrossRefGoogle ScholarPubMed
McCallum, W. C. & Walter, W. G. (1968). The effects of attention and distraction on the contingent negative variation in normal and neurotic subjects. Electroencephalography and Clinical Neurophysiology 35, 319–329.CrossRefGoogle Scholar
Marczynski, T. J. (1986). A model of brain function. In Cerebral Psychophysiology: Studies in Event-Related Potentials (EEG Suppl. 38) (ed. McCallum, W. C.Zappoli, R. and Denoth, F.), pp. 351–367. Elsevier Science Publishers B.V.: Amsterdam.Google Scholar
Mills, I. (1977). Noradrenaline and the coping process in the brain. In Depression - the Biochemical and Physiological of Ludiomil (ed. Jukes, A.), pp. 53–58. Ciba Laboratories: Horsham, England.Google Scholar
O'Brien, G., Holton, A. R., Hurren, K., Watt, L. & Hassanyeh, F. (1987). Deliberate self-harm-correlates of suicidal intent and severity of depression. Acta Psychiatrica Scandinavica 75,474–477.CrossRefGoogle ScholarPubMed
Rebert, C. S. (1972). Cortical and subcortical slow potentials in the monkey's brain during a preparatory interval. Electroencephalography and Clinical Neurophysiology 33, 389–402.CrossRefGoogle ScholarPubMed
Rizzo, P. A., Amabile, G., Caporali, M., Pierelli, F., Spadaro, M., Zanasi, M. & Morocutti, C. (1979). A longitudinal CNV study in a group of five bipolar cyclothymic patients. Biological Psychiatry 14, 581–586.Google Scholar
Roth, W. T., Pfeffersbaum, A., Kelly, A. F., Beyer, P. A. & Kopell, B. S. (1981). Auditory event-related potentials in schizophrenia and depression. Psychiatry Research 4, 199–212.CrossRefGoogle ScholarPubMed
Satterfield, J. H. (1972). Auditory evoked cortical response studies in depressed patients and normal control subjects. In Recent Advances in the Psychobiology of the Depressive Illness (ed. Williams, T. A.Katz, M. M. and Shield, J. R. Jr,), pp. 87–98. Publ. No. (HSM) 70–9053. U.S. Government Printing Office DHEW: Washington DC.Google Scholar
Schwab, J. J., Bialow, M. R. & Holzer, C. E. (1967). A comparison of two rating scales for depression. Journal of Clinical Psychology 23, 94–96.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Seligman, M. E. P. (1975). Helplessness, on Depression, Development and Death. Freeman: San Francisco.Google Scholar
Shagass, C. (1977). Twisted thoughts, twisted brainwaves? In Psychopathology and Brain Dysfunction (ed. Shagass, C.Gershon, S. and Fnedhoff, A. J.), pp. 353–378. Raven Press: New York.Google Scholar
Shagass, C., Ornitz, E. M., Sutton, S. & Tueting, P. (1978 a). Eventrelated potentials and psychopathology. In Event-related Brain Potentials in Man (ed. Callaway, E.Tueting, P. & Koslow, S. H.), pp. 443–495. Academic Press: New York.CrossRefGoogle Scholar
Shagass, C.Roemer, R. A., Straumenis, J. J. & Armadeo, M. (1978 b). Evoked potential correlates of psychosis. Biological Psychiatry 13, 163–184.Google ScholarPubMed
Shagass, C., Roemer, R. A., Straumenis, J. J. & Josiassen, R. C. (1985). Combinations of evoked potential amplitude measurements in relation is psychiatric diagnosis. Biological Psychiatry 20, 701–702.CrossRefGoogle ScholarPubMed
Small, J. G. & Small, I. F. (1971). Contingent negative variation (CNV) correlation with psychiatric diagnosis. Archives of General Psychiatry 25, 550–554.CrossRefGoogle ScholarPubMed
Small, J. G., Small, I. F. & Perez, H. C. (1971). EEG, evoked potential, and contingent negative variations with lithium in manic depressive disease. Biological Psychiatry 3, 47–58.Google ScholarPubMed
Speck, L. B., Dim, B. & Mercer, M. (1966). Visual evoked responses of psychiatric patients. Archives of General Psychiatry 15, 59–63.CrossRefGoogle ScholarPubMed
Stanley, M. & Mann, J. J. (1983). Increased serotonin-2 binding sites in frontal cortex of suicide victims. Lancet i, 214–216.CrossRefGoogle Scholar
Stanley, M. & Mann, J. J. (1984). Suicide and serotonin receptors. Lancet i, 349.CrossRefGoogle Scholar
Stanley, M., Virgilio, J. & Gershon, S. (1982). Tritiated imipramine binding sites are decreased in the frontal cortex of suicide victims. Science 216, 1337–1339.CrossRefGoogle Scholar
Straumenis, J. J., Shagass, C., Roemer, R. A., Mendels, J. & Ramsay, T. A. (1981). Cerebral evoked potential change produced by treatment with lithium carbonate. Biological Psychiatry 16, 113–129.Google Scholar
Tecce, J. J., Savignano-Bowman, J. & Meinbresse, D. (1976). Contingent negative variation and the distraction-arousal hypothesis. Electroencephalography and Clinical Neurophysiology 41, 277–286.CrossRefGoogle ScholarPubMed
Thier, P., Axmann, D. & Giedke, H. (1986). Slow brain potentials and psychomotor retardation in depression. Electroencephalography and Clinical Neurophysiology 63, 570–581CrossRefGoogle ScholarPubMed
Thompson, J. W., Newton, P., Pocock, P. V., Cooper, R., Crow, H., McCallum, W. C. & Papakostopoulos, D. A. (1978). A preliminary study of pharmacology of contingent negative variation in man. In Multidisciplinary Perspectives in Event-Related Brain Potential Research (ed. Otto, D. A.), pp. 51–55. U.S. Government Printing Office: Washington DC.Google Scholar
Timsit-Berthier, M. (1981). A propos de l'inteipretation de la variation contingente negative en psychiatric Reviews of EEG and Neurophysiology 11, 236–244.Google Scholar
Timsit-Berthier, M., Gerono, A., Grisar, T. & Timsit, M. (1981). Toward new interpretive views of CNV in neuropsychiatry. Abstract of poster at Sixth International Conference on Event Related Slow Potentials.EPIC VI. Lake Forest,Illinois U.S.A.Google Scholar
Traskman, L., Åsberg, M., Bartilsson, L. & Sjostrand, L. (1981). Monoamine metabolites in CSF and suicidal behaviour. Archives of General Psychiatry 38, 631–636.CrossRefGoogle Scholar
Vasconetto, C., Floris, V. & Morocutti, C. (1971). Visual evoked response in normal and psychiatric subjects. Electroencephalography and Clinical Neurophysiology 31, 77–83.CrossRefGoogle ScholarPubMed
Walter, W. G. (1971). Physiological correlates of personality. Biological Psychiatry 3, 59.Google ScholarPubMed
Weckowicz, T. E., Chung-Ngok, I. F., Mason, J. & Kyung, S. B. (1978). Speed in test performance in depressed patients. Journal of Abnormal Psychology 87, 578–582.CrossRefGoogle ScholarPubMed
Willner, P. (1984). The validity of animal models of depression. Psychopharmacology 83, 1–16CrossRefGoogle ScholarPubMed
World Health Organization (1978). International Classification of Mental Disorders: Glossary and Guide to the Classification in Accordance with the 9th Revision of the International Classification of Diseases. WHO: Geneva.Google Scholar