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A controlled study of 99mTc-HMPAO single-photon emission imaging in chronic schizophrenia

  • S. W. Lewis (a1), R. A. Ford (a1), G. M. Syed (a1), A. M. Reveley (a1) and B. K. Toone (a1)...


Regional cerebral blood flow (rCBF) during a word fluency task was compared in twenty-five male, right-handed, medicated schizophrenic patients and twenty-five age-matched male, right-handed healthy volunteers, using 99mtechnetium-HMPAO multidetector single-photon emission tomography. Increased rCBF in caudate and thalamus was found in patients, probably secondary to neuroleptic medication. Patients showed decreased rCBF in left frontal cortical regions and increased rCBF in left posterior cortical regions, compared to controls. Patterns of left-sided frontal rCBF dominance in controls were reversed in patients, as were normal patterns of right-sided parietal rCBF dominance. Negative symptom score correlated inversely with mesial frontal rCBF, particularly on the left.


Corresponding author

1 Address for correspondence: Dr S. W. Lewis, Department of Psychiatry, Charing Cross and Westminster Medical School, London W6 8RP.


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Allen, H., Frith, C. & Liddle, P. (1990). Mechanisms underlying abnormalities in verbal fluency in schizophrenia. Schizophrenia Research 3, 6768.
Annett, M. (1970). The classification of hand preference by association analysis. British Journal of Psychology 6, 278296.
Bajc, M., Medved, V., Basic, M., Topuzpvic, N. & Babic, D. (1989). Cerebal perfusion inhomogeneities in schizophrenia demonstrated with single photon emission computed tomography and Tc99m-HMPAO. Acta Psychiatrica Scandinavia 80, 427433.
Benes, F. M. & Bird, E. D. (1986). An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. Archives of General Psychiatry 44, 608616.
Benton, A. L. (1968). Differential effects of frontal lobe disease. Neuropsychologia 6, 5360.
Buchsbaum, M. S. & Haier, R. J. (1987). Functional and anatomical brain imaging: impact on schizophrenia research. Schizophrenia Bulletin 13, 115132.
Buchsbaum, M. S., Wu, J. C., DeLisi, L. E., Holcomb, H. H., Hazlett, E., Cooper-Langston, K. & Kessler, R. (1987). Positron emission tomography studies of basal ganglia and somato-sensory cortex neuroleptic drug affects: differences between normal controls and schizophrenic patients. Biological Psychiatry 22, 479494.
Buchsbaum, M. S., Neuchterlein, K. H., Haier, R. J., Wu, J., Sicotte, N., Hazlett, E., Asarnow, R., Hopkin, S. & Guich, S. (1990). Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by positron emission tomography. British Journal of Psychiatry 156, 216227.
Cleghorn, J. M., Kaplan, R. D., Nahmias, C., Garnett, E. S., Szechtman, H. & Szechtman, B. (1989). Inferior parietal region implicated in neurocognitive impairment in schizophrenia. Archives of General Psychiatry 46, 758759.
Damasio, H. & Damasio, A. R. (1989). Lesion Analysis in Neuropsychology. Oxford University Press: New York.
DeLisi, L. E., Holcomb, H. H., Cohen, R. M., Pickar, D., Carpenter, W., Morihisa, J. M., King, A. C., Kessler, R. & Buchsbaum, M. S. (1985). Positron emission tomography in schizophrenic patients with and without neuroleptic medication. Journal of Cerebral Blood Flow and Metabolism 5, 201206.
DeLisi, L. E., Buchsbaum, M. S., Holcomb, H. H., Langston, K. C., King, A. C., Kessler, R., Pickar, D., Carpenter, W., Morihisa, J. M., Margolin, R. & Weinberger, D. R. (1989). Increased temporal lobe glucose use in chronic schizophrenic patients. Biological Psychiatry 25, 835851.
Early, T. S., Posner, M. I., Reiman, E. M. & Raichle, M. E. (1989). Left striato-pallidal hyperactivity in schizophrenia. 2. Phenomenology and thought disorder. Psychiatric Developments 2, 109121.
Franzen, G. & Ingvar, D. H. (1975). Absence of activation in frontal structures during psychological testing of chronic schizophrenics. Journal of Neurology, Neurosurgery and Psychiatry 38, 10271032.
Frith, C. J. & Done, D. J. (1988). Towards a neuropsychology of schizophrenia. British Journal of Psychiatry 153, 437443.
Gruzelier, J., Seymour, K., Wilson, L., Jolley, A. & Hirsch, S. (1988). Impairments on neuropsychological tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623629.
Gruzelier, J., Liddiard, D., Davis, L. & Wilson, L. (1990). Topographical EEG differences between schizophrenic patients and controls during neuropsychological functional activation. International Journal of Psychophysiology 8, 275282.
Gur, R. E., Resnick, S. M. & Gur, R. C. (1989). Laterality and frontality of cerebral blood flow and metabolism in schizophrenia: relationship to symptom specificity. Psychiatric Research 27, 325334.
Iager, A. C., Kirch, D. G. & Wyatt, T. J. (1985). A negative symptom rating scale. Psychiatry Research 16, 2736.
Ingvar, D. H. & Franzen, G. (1974). Distribution of cerebral activity in chronic schizophrenia. Lancet ii, 14841486.
Jarritt, P. H., Eli, P. J., Myers, M. J., Brown, N. J. & Deacon, J. M. (1979). A new transverse section brain imager for single gamma emitters. Journal of Nuclear Medicine 20, 319327.
Kolb, B. & Whishaw, I. Q. (1983). Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients. Journal of Nervous and Mental Disease 171, 435443.
Kolb, B. & Whishaw, I. Q. (1987). Fundamentals of Human Neuropsychology. W. H. Freeman: New York.
Lassen, N. A., Anderson, R. A., Friberg, H. & Paulson, O. B. (1988). The retention of 99m-Tc HMPAO in the human brain after intracarotid bolus injection: a kinetic analysis. Journal of Cerebral Blood Flow and Metabolism 8, 513522.
Levin, S., Yurgelun-Todd, D. & Craft, S. (1989). Contributions of clinical neuropsychology to the study of schizophrenia. Journal of Abnormal Psychology 98, 341356.
Liddle, P. F. (1987). Schizophrenic syndromes, cognitive performance and neurological dysfunction. Psychological Medicine 17, 4957.
Mathew, R. J., Wilson, W. H., Hant, S. R., Robinson, L. & Prakash, R. (1988). Abnormal resting regional cerebral blood flow patterns and their correlates in schizophrenia. Archives of General Psychiatry 45, 542549.
Matsuda, H., Gyobu, T. II, M, et al. (1988). Increased accumulation of n-isopropyl (I123) p-iodo-amphetamine in the left auditory area in a schizophrenic patient with auditory hallucinations. Clinics in Nuclear Medicine 13, 5355.
Miller, E. (1984). Verbal fluency as a function of a measure of verbal intelligence and in relation to different types of cerebral pathology. British Journal of Clinical Psychology 23, 5357.
Milner, B. (1964). Some effects of frontal lobectomy in man. In The Frontal Granular Cortex and Behaviour (ed. Warren, J. M. and Akert, K.), pp. 313334. McGraw-Hill: New York.
Nelson, H. & O'Connell, A. (1978). Dementia: the estimation of premorbid intelligence using the new Adult Reading Test. Cortex 14, 234244.
Resnick, S. M., Gur, R. E., Alavi, A., Gur, R. C. & Reivich, M. (1988). Positron emission tomography and subcortical glucose metabolism in schizophrenia. Psychiatry Research 24, 111.
Sharp, F. P., Smith, F. W., Gemmel, H. G., Lyall, D., Evans, N. T. S., Guordanovic, D., Davison, J., Tyrell, D. A., Pickett, R. D. & Neuinckx, R. (1986). Technetium-99m HMPAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies. Journal of Nuclear Medicine 27, 171177.
Sheppard, G., Gruzelier, J., Manchanda, R., Hirsch, S., Wise, R., Frackowiac, R., Jones, B. & Jones, T. (1983). 150-Positron emission tomography scanning in predominantly never treated acute schizophrenics. Lancet ii, 14481452.
Szechtman, H. N. C., Nahmias, C., Garnett, S., Firnau, G., Brown, G. M., Kaplin, R. D. & Cleghorn, J. M. (1988). Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Archives of General Psychiatry 45, 523532.
Toru, M., Watanabe, S., Shibuya, H., Nishikawa, T., Noda, K., Mitsushio, H., Ichikawa, H., Kuramaji, A., Takashima, M., Mataga, N. & Ogawa, A. (1988). Neurotransmitters, receptors and neuropeptides in post-mortem brains of chronic schizophrenic patients. Acta Psychiatrica Scandinavica 78, 121127.
Volkow, N. D., Brodie, J. D., Wolf, A. P., Angrist, B., Russell, J. & Cancrow, R. (1986). Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration. Journal of Neurology, Neurosurgery and Psychiatry 49, 11991202.
Weinberger, R., Berman, K. F. & Zec, R. F. (1986). Physiological function of dorsal lateral pre frontal cortex in schizophrenia. 1. Regional cerebral blood flow evidence. Archives of General Psychiatry 43, 114125.
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Description of Psychiatric Symptoms: An Introductory Manual for PSE Cambridge University Press: Cambridge.
Wolkin, A., Jaeger, J., Brodie, J. D., Wolf, A. P., Fowler, J., Rotrosen, J., Gomez-Mont, F. & Cancro, R. (1985). Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. American Journal of Psychiatry 142, 564571.

A controlled study of 99mTc-HMPAO single-photon emission imaging in chronic schizophrenia

  • S. W. Lewis (a1), R. A. Ford (a1), G. M. Syed (a1), A. M. Reveley (a1) and B. K. Toone (a1)...


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