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Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder

  • C. O. Carlisi (a1), L. Norman (a1), C. M. Murphy (a1) (a2) (a3), A. Christakou (a4), K. Chantiluke (a1), V. Giampietro (a5), A. Simmons (a5) (a6) (a7), M. Brammer (a5), D. G. Murphy (a2) (a3), MRC AIMS consortium, D. Mataix-Cols (a8) and K. Rubia (a1)...

Abstract

Background

Autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD) share abnormalities in hot executive functions such as reward-based decision-making, as measured in the temporal discounting task (TD). No studies, however, have directly compared these disorders to investigate common/distinct neural profiles underlying such abnormalities. We wanted to test whether reward-based decision-making is a shared transdiagnostic feature of both disorders with similar neurofunctional substrates or whether it is a shared phenotype with disorder-differential neurofunctional underpinnings.

Methods

Age and IQ-matched boys with ASD (N = 20), with OCD (N = 20) and 20 healthy controls, performed an individually-adjusted functional magnetic resonance imaging (fMRI) TD task. Brain activation and performance were compared between groups.

Results

Boys with ASD showed greater choice-impulsivity than OCD and control boys. Whole-brain between-group comparison revealed shared reductions in ASD and OCD relative to control boys for delayed-immediate choices in right ventromedial/lateral orbitofrontal cortex extending into medial/inferior prefrontal cortex, and in cerebellum, posterior cingulate and precuneus. For immediate-delayed choices, patients relative to controls showed reduced activation in anterior cingulate/ventromedial prefrontal cortex reaching into left caudate, which, at a trend level, was more decreased in ASD than OCD patients, and in bilateral temporal and inferior parietal regions.

Conclusions

This first fMRI comparison between youth with ASD and with OCD, using a reward-based decision-making task, shows predominantly shared neurofunctional abnormalities during TD in key ventromedial, orbital- and inferior fronto-striatal, temporo-parietal and cerebellar regions of temporal foresight and reward processing, suggesting trans-diagnostic neurofunctional deficits.

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Copyright

This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

Corresponding author

*Address for correspondence: C. Carlisi, BA, Department of Child and Adolescent Psychiatry/MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 DeCrespigny Park, London, SE5 8AF, UK. (Email: carlisi.christina@gmail.com)

Footnotes

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CC and LN contributed equally to this work.

The MRC AIMS Consortium is a collaboration of Autism research centres in the UK including the Institute of Psychiatry, Psychology & Neuroscience. London, the Autism Research Centre, University of Cambridge, and the Autism Research Group, University of Oxford. It is funded by the MRC UK and headed by the Department of Forensic and Developmental Sciences, Institute of Psychiatry, Psychology & Neuroscience. The Consortium members are in alphabetical order: Bailey A.J., Baron-Cohen S., Bolton P.F., Bullmore E.T., Carrington S., Chakrabarti B., Daly E.M., Deoni S.C., Ecker C,. Happe F., Henty J., Jezzard P., Johnston P., Jones D.K., Lombardo M., Madden A., Mullins D., Murphy C.M., Murphy D.G., Pasco G., Sadek S., Spain D., Steward R., Suckling J., Wheelwright S., Williams S.C.

Footnotes

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Comparison of neural substrates of temporal discounting between youth with autism spectrum disorder and with obsessive-compulsive disorder

  • C. O. Carlisi (a1), L. Norman (a1), C. M. Murphy (a1) (a2) (a3), A. Christakou (a4), K. Chantiluke (a1), V. Giampietro (a5), A. Simmons (a5) (a6) (a7), M. Brammer (a5), D. G. Murphy (a2) (a3), MRC AIMS consortium, D. Mataix-Cols (a8) and K. Rubia (a1)...

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