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Common mental disorders in young adults born late-preterm

  • K. Heinonen (a1), E. Kajantie (a2) (a3) (a4), A.-K. Pesonen (a1), M. Lahti (a1), S. Pirkola (a2) (a5), D. Wolke (a6), A. Lano (a4), S. Sammallahti (a1) (a2) (a4), J. Lahti (a1) (a7), S. Andersson (a4), J. G. Eriksson (a2) (a8) (a9) (a10) and K. Raikkonen (a1)...



Results of adulthood mental health of those born late-preterm (34 + 0–36 + 6 weeks + days of gestation) are mixed and based on national registers. We examined if late-preterm birth was associated with a higher risk for common mental disorders in young adulthood when using a diagnostic interview, and if this risk decreased as gestational age increased.


A total of 800 young adults (mean = 25.3, s.d. = 0.62 years), born 1985–1986, participated in a follow-up of the Arvo Ylppö Longitudinal Study. Common mental disorders (mood, anxiety and substance use disorders) during the past 12 months were defined using the Composite International Diagnostic Interview (Munich version). Gestational age was extracted from hospital birth records and categorized into early-preterm (<34 + 0, n = 37), late-preterm (34 + 0–36 + 6, n = 106), term (37 + 0–41 + 6, n = 617) and post-term (⩾42 + 0, n = 40).


Those born late-preterm and at term were at a similar risk for any common mental disorder [odds ratio (OR) 1.11, 95% confidence interval (CI) 0.67–1.84], for mood (OR 1.11, 95% CI 0.54–2.25), anxiety (OR 1.00, 95% CI 0.40–2.50) and substance use (OR 1.31, 95% CI 0.74–2.32) disorders, and co-morbidity of these disorders (p = 0.38). While the mental disorder risk decreased significantly as gestational age increased, the trend was driven by a higher risk in those born early-preterm.


Using a cohort born during the advanced neonatal and early childhood care, we found that not all individuals born preterm are at risk for common mental disorders in young adulthood – those born late-preterm are not, while those born early-preterm are at a higher risk. Available resources for prevention and intervention should be targeted towards the preterm group born the earliest.


Corresponding author

*Address for correspondence: Dr K. Heinonen, Institute of Behavioural Sciences, P.O. Box 9, 00014 University of Helsinki, Helsinki, Finland. (Email:


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Andrews, G, Peters, L (1998). The psychometric properties of the Composite International Diagnostic Interview. Social Psychiatry and Psychiatric Epidemiology 33, 8088.
Bilgin, A, Wolke, D (2015). Maternal sensitivity in parenting preterm children: a meta-analysis. Pediatrics 136, e177e193.
Blanco, C, Okuda, M, Wright, C, Hasin, DS, Grant, BF, Liu, S-M, Olfson, M (2008). Mental health of college students and their non-college-attending Peers: results from the National Epidemiologic Study on alcohol and related conditions. Archives of General Psychiatry 65, 14291437.
Blencowe, H, Cousens, S, Oestergaard, MZ, Chou, D, Moller, AB, Narwal, R, Adler, A, Vera Garcia, C, Rohde, S, Say, L, Lawn, JE (2012). National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. The Lancet 379, 21622172.
Bruffaerts, R, Posada-Villa, J, Al-Hamzawi, AO, Gureje, O, Huang, Y, Hu, C, Bromet, EJ, Viana, MC, Hinkov, HR, Karam, EG, Borges, G, Floresce, SE, Williams, DR, Demyttenaere, K, Kovess, V, Matschinger, H, Levinson, D, de Girolamo, G, Ono, Y, de Graaf, R, Browne, MO, Bunting, B, Xavier, M, Haro, JM, Kessler, RC (2015). Proportion of patients without mental disorders being treated in mental health services worldwide. British Journal of Psychiatry 206, 101109.
Bäuml, JG, Daamen, M, Meng, C, Neitzel, J, Scheef, L, Jaekel, J, Busch, B, Baumann, N, Bartmann, P, Wolke, D, Boecker, H, Wohlschläger, AM, Sorg, C (2014). Correspondence between aberrant intrinsic network connectivity and gray-matter volume in the ventral brain of preterm born adults. Cerebral Cortex 25, 41354145.
D'Onofrio, BM, Class, QA, Rickert, ME, Larsson, H, Långström, N, Lichtenstein, P (2013). Preterm birth and mortality and morbidity: a population-based quasi-experimental study. JAMA Psychiatry 70, 12311240.
Davidoff, MJ, Dias, T, Damus, K, Russell, R, Bettegowda, VR, Dolan, S, Schwarz, RH, Green, NS, Petrini, J (2006). Changes in the gestational age distribution among U.S. singleton births: impact on rates of late preterm birth, 1992 to 2002. Seminars in Perinatology 30, 815.
Demyttenaere, K, Bruffaerts, R, Posada-Villa, J, Gasquet, I, Kovess, V, Lepine, JP, Angermeyer, MC, Bernert, S, de Girolamo, G, Morosini, P, Polidori, G, Kikkawa, T, Kawakami, N, Ono, Y, Takeshima, T, Uda, H, Karam, EG, Fayyad, JA, Karam, AN, Mneimneh, ZN, Medina-Mora, ME, Borges, G, Lara, C, de Graaf, R (2004). Prevalence, severity, and Unmet need for treatment of mental disorders in the World Health Organization World mental health surveys. Journal of the American Medical Association 291, 25812590.
Engle, WA (2011). Morbidity and mortality in late preterm and early term newborns: a continuum. Clinics in Perinatology 38, 493516.
Engle, WA, Tomashek, KM, Wallman, C (2007). ‘Late-preterm’ infants: a population at risk. Pediatrics 120, 13901401.
Haro, JM, Arbabzadeh-Bouchez, S, Brugha, TS, de Girolamo, G, Guyer, ME, Jin, R, Lepine, JP, Mazzi, F, Reneses, B, Vilagut, G, Sampson, NA, Kessler, RC (2006). Concordance of the composite international diagnostic interview version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health surveys. International Journal of Methods in Psychiatric Research 15, 167180.
Harris, MN, Voigt, RG, Barbaresi, WJ, Voge, Ga., Killian, JM, Weaver, AL, Colby, CE, Carey, WA, Katusic, SK (2013). ADHD and learning disabilities in former late preterm infants: a population-based birth cohort. Pediatrics 132, e630e636.
Heinonen, K, Räikkönen, K, Pesonen, A-K, Kajantie, E, Andersson, S, Eriksson, JG, Niemelä, A, Vartia, T, Peltola, J, Lano, A (2008). Prenatal and postnatal growth and cognitive abilities at 56 months of age: a longitudinal study of infants born at term. Pediatrics 121, e1325e1333.
Hemmi, MH, Wolke, D, Schneider, S (2011). Associations between problems with crying, sleeping and/or feeding in infancy and long-term behavioural outcomes in childhood: a meta-analysis. Archives of Disease in Childhood 96, 622629.
Indredavik, MS, Vik, T, Evensen, KAI, Skranes, J, Taraldsen, G, Brubakk, A-M (2010). Perinatal risk and psychiatric outcome in adolescents born preterm with very low birth weight or term small for gestational age. Journal of Developmental & Behavioral Pediatrics 31, 286294.
Jacobi, F, Wittchen, H-U, Holting, C, Hofler, M, Pfister, M, Muller, N, Lieb, R (2004). Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS). Psychological Medicine 34, 597611.
Jaekel, J, Pluess, M, Belsky, J, Wolke, D (2014). Effects of maternal sensitivity on low birth weight children's academic achievement: a test of differential susceptibility versus diathesis stress. Journal of Child Psychology and Psychiatry 6, 693701.
Johnson, S, Hollis, C, Kochhar, P, Hennessy, E, Wolke, D, Marlow, N (2010). Psychiatric disorders in extremely preterm children: longitudinal finding at age 11 years in the EPICure study. Journal of the American Academy of Child and Adolescent Psychiatry 49, 453463.e1.
Johnson, S, Marlow, N (2011). Preterm birth and childhood psychiatric disorders. Pediatric Research 69, 2228.
Kelly, CE, Cheong, JLY, Gabra Fam, L, Leemans, A, Seal, ML, Doyle, LW, Anderson, PJ, Spittle, AJ, Thompson, DK (2016). Moderate and late preterm infants exhibit widespread brain white matter microstructure alterations at term-equivalent age relative to term-born controls. Brain Imaging and Behavior 10, 4149.
Lahti, M, Eriksson, JG, Heinonen, K, Kajantie, E, Lahti, J, Wahlbeck, K, Tuovinen, S, Pesonen, A-K, Mikkonen, M, Osmond, C, Barker, DJP, Räikkönen, K (2015). Late preterm birth, post-term birth, and abnormal fetal growth as risk factors for severe mental disorders from early to late adulthood. Psychological Medicine 45, 985999.
Laptook, AR (2013). Neurologic and metabolic issues in moderately preterm, late preterm, and early term infants. Clinics in Perinatology 40, 724738.
Lindström, K, Lindblad, F, Hjern, A (2009). Psychiatric morbidity in adolescents and young adults born preterm: a Swedish national cohort study. Pediatrics 123, e47e53.
Linnet, KM, Wisborg, K, Agerbo, E, Secher, NJ, Thomsen, PH, Henriksen, TB (2006). Gestational age, birth weight, and the risk of hyperkinetic disorder. Archives of Disease in Childhood 91, 655660.
Mathiasen, R, Hansen, BM, Forman, JL, Kessing, LV, Greisen, G (2011). The risk of psychiatric disorders in individuals born prematurely in Denmark from 1974 to 1996. Acta Paediatrica 100, 691699.
Milligan, DW (2010). Outcomes of children born very preterm in Europe. Archives of Disease in Childhood Fetal and Neonatal Edition 95, F234F240.
Moster, D, Lie, RT, Markestad, T (2008). Long-term medical and social consequences of preterm birth. New England Journal of Medicine 359, 262273.
Munakata, S, Okada, T, Okahashi, A, Yoshikawa, K, Usukura, Y, Makimoto, M, Hosono, S, Takahashi, S, Mugishima, H, Okuhata, Y (2013). Gray matter volumetric MRI differences late-preterm and term infants. Brain and Development 35, 1016.
Nosarti, C, Reichenberg, A, Murray, RM, Cnattingius, S, Lambe, MP, Yin, L, MacCabe, J, Rifkin, L, Hultman, CM (2012). Preterm birth and psychiatric disorders in young adult life: preterm birth and psychiatric disorders. Archives of General Psychiatry 69, 610617.
Pihkala, J, Hakala, T, Voutilainen, P, Raivio, K (1989). Characteristic of recent fetal growth curves in Finland. Duodecim 105, 15401546.
Pirkola, SP, Isometsä, E, Suvisaari, J, Aro, H, Joukamaa, M, Poikolainen, K, Koskinen, S, Aromaa, A, Lönnqvist, JK (2005). DSM-IV mood-, anxiety- and alcohol use disorders and their co-morbidity in the Finnish general population. Results from the Health 2000 Study. Social Psychiatry and Psychiatric Epidemiology 40, 110.
Raikkonen, K, Pesonen, A-K, Heinonen, K, Kajantie, E, Hovi, P, Jarvenpaa, A-L, Eriksson, JG, Andersson, S (2008). Depression in young adults with very low birth weight: the Helsinki Study of very low-birth-weight adults. Archives of General Psychiatry 65, 290296.
Rogers, CE, Anderson, PJ, Thompson, DK, Kidokoro, H, Wallendorf, M, Treyvaud, K, Roberts, G, Doyle, LW, Neil, JJ, Inder, TE (2012). Regional cerebral development at term relates to school-age social-emotional development in very preterm children. Journal of the American Academy of Child and Adolescent Psychiatry 51, 181191.
Rogers, CE, Barch, DM, Sylvester, CM, Pagliaccio, D, Harms, MP, Botteron, KN, Luby, JL (2014). Altered Gray Matter volume and School age anxiety in children born late preterm. Journal of Pediatrics 165, 18.
Rogers, CE, Lenze, SN, Luby, JL (2013). Late preterm birth, maternal depression, and risk of preschool psychiatric disorders. Journal of the American Academy of Child and Adolescent Psychiatry 52, 309318.
Shah, PE, Robbins, N, Coelho, RB, Poehlmann, J (2013). The paradox of prematurity: the behavioral vulnerability of late preterm infants and the cognitive susceptibility of very preterm infants at 36 months post-term. Infant Behavior and Development 36, 5062.
Skranes, J, Vangberg, TR, Kulseng, S, Indredavik, MS, Evensen, KI, Martinussen, M, Dale, aM, Haraldseth, O, Brubakk, aM (2007). Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight. Brain 130, 654666.
Strang-Karlsson, S, Räikkönen, K, Pesonen, AK, Kajantie, E, Paavonen, EJ, Lahti, J, Hovi, P, Heinonen, K, Järvenpää, AL, Eriksson, JG, Andersson, S (2008). Very low birth weight and behavioral symptoms of attention deficit hyperactivity disorder in young adulthood: the Helsinki study of very-low-birth-weight adults. American Journal of Psychiatry 165, 13451353.
Talge, NM, Holzman, C, Wang, J, Lucia, V, Gardiner, J, Breslau, N (2010). Late-preterm birth and its association with cognitive and socioemotional outcomes at 6 years of age. Pediatrics 126, 11241131.
Ten Have, M, Nuyen, J, Beekman, A, de Graaf, R (2013). Common mental disorder severity and its association with treatment contact and treatment intensity for mental health problems. Psychological Medicine 43, 22032213.
Treyvaud, K, Ure, A, Doyle, LW, Lee, KJ, Rogers, CE, Kidokoro, H, Inder, TE, Anderson, PJ (2013). Psychiatric outcomes at age seven for very preterm children: rates and predictors. Journal of Child Psychology and Psychiatry 54, 772779.
Van Lieshout, RJ, Boyle, MH, Saigal, S, Morrison, K, Schmidt, LA (2015). Mental health of extremely low birth weight survivors in their 30s. Pediatrics 135, 452459.
Voegtline, KM, Stifter, CA (2010). Late-preterm birth, maternal symptomatology, and infant negativity. Infant Behavior and Development 33, 545554.
Whitaker, AH, Van Rossem, R, Feldman, JF, Schonfeld, IS, Pinto-Martin, JA, Tore, C, Shaffer, D, Paneth, N (1997). Psychiatric outcomes in low-birth-weight children at age 6 years: relation to neonatal cranial ultrasound abnormalities. Archives of General Psychiatry 54, 847856.
Wittchen, H-U, Lachner, G, Wunderlich, U, Pfister, H (1998). Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI). Social Psychiatry and Psychiatric Epidemiology 33, 568578.
Wittchen, H-U, Pfister, H (1997). DIA-X-Interviews: Manual für screening-verfahren und Interview; Interviewheft Längsschnittuntersuchung (DIA-X-Lifetime); Ergänzungsheft (DIAX- Lifetime); Interviewheft Querschnittuntersuchung (DIA-X-12 Monate); Ergänzungsheft (DIA-X-12 Monate); PC-Program. Swets and Zeitlinger: Frankfurt.
Wolke, D, Eryigit-Madzwamuse, S, Gutbrod, T (2014). Very preterm/very low birthweight infants’ attachment: infant and maternal characteristics. Archives of Disease in Childhood. Fetal and Neonatal Edition 99, 7075.
Wolke, D, Söhne, B, Riegel, K, Ohrt, B, Österlund, K (1998). An epidemiologic longitudinal study of sleeping problems and feeding experience of preterm and term children in southern Finland: comparison with a southern German population sample. Journal of Pediatrics 133, 224231.


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Common mental disorders in young adults born late-preterm

  • K. Heinonen (a1), E. Kajantie (a2) (a3) (a4), A.-K. Pesonen (a1), M. Lahti (a1), S. Pirkola (a2) (a5), D. Wolke (a6), A. Lano (a4), S. Sammallahti (a1) (a2) (a4), J. Lahti (a1) (a7), S. Andersson (a4), J. G. Eriksson (a2) (a8) (a9) (a10) and K. Raikkonen (a1)...


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