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Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder

  • K. S. Blair (a1), M. Vythilingam (a1), S. L. Crowe (a1), D. E. McCaffrey (a1), P. Ng (a1), C. C. Wu (a1), M. Scaramozza (a1), K. Mondillo (a1), D. S. Pine (a1), D. S. Charney (a2) and R. J. R. Blair (a1)...

Abstract

Background

This study aimed to determine whether patients with post-traumatic stress disorder (PTSD) show difficulty in recruitment of the regions of the frontal and parietal cortex implicated in top-down attentional control in the presence and absence of emotional distracters.

Method

Unmedicated individuals with PTSD (n = 14), and age-, IQ- and gender-matched individuals exposed to trauma (n = 15) and healthy controls (n = 19) were tested on the affective number Stroop task. In addition, blood oxygen level-dependent responses, as measured via functional magnetic resonance imaging, were recorded.

Results

Patients with PTSD showed disrupted recruitment of lateral regions of the superior and inferior frontal cortex as well as the parietal cortex in the presence of negative distracters. Trauma-comparison individuals showed indications of a heightened ability to recruit fronto-parietal regions implicated in top-down attentional control across distracter conditions.

Conclusions

These results are consistent with suggestions that emotional responsiveness can interfere with the recruitment of regions implicated in top-down attentional control; the heightened emotional responding of patients with PTSD may lead to the heightened interference in the recruitment of these regions.

Copyright

Corresponding author

*Address for correspondence: K. S. Blair, Ph.D., National Institute of Mental Health, 15K North Drive, MSC 2670, Bethesda, MD 20892, USA. (Email: peschark@mail.nih.gov)

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Keywords

Cognitive control of attention is differentially affected in trauma-exposed individuals with and without post-traumatic stress disorder

  • K. S. Blair (a1), M. Vythilingam (a1), S. L. Crowe (a1), D. E. McCaffrey (a1), P. Ng (a1), C. C. Wu (a1), M. Scaramozza (a1), K. Mondillo (a1), D. S. Pine (a1), D. S. Charney (a2) and R. J. R. Blair (a1)...

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