Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-17T14:51:48.928Z Has data issue: false hasContentIssue false
  • English
  • Français

Clinical and biochemical comparison of clorazepate and diazepam

Published online by Cambridge University Press:  09 July 2009

Ashley Robin ,
Stephen H. Curry  and
Robin Whelpton
Ashley Robin*
Affiliation:
From Runwell Hospital, Essex, and the Department of Pharmacology and Therapeutics, The London Hospital Medical College, London
Stephen H. Curry
Affiliation:
From Runwell Hospital, Essex, and the Department of Pharmacology and Therapeutics, The London Hospital Medical College, London
Robin Whelpton
Affiliation:
From Runwell Hospital, Essex, and the Department of Pharmacology and Therapeutics, The London Hospital Medical College, London
*
1Address for correspondence: Dr. Ashley Robin, Runwell Hospital, Wickford, Essex.
Get access Rights & Permissions [Opens in a new window]

Sysnopsis

Clorazepate and diazepam were compared with respect to clinical effectiveness and concentrations of benzodiazepine compounds in plasma in 15 severely anxious outpatients. Each patient was studied in a double blind trial incorporating two-week periods of the two drugs and of placebo. The doses were almost equimolar—5 mg diazepam or 7·5 mg clorazepate three times daily. Clinical progress was assessed by visual analogue scales and by the Symptom Rating Test. Psychopathology scores were highest at the end of the placebo periods, and lowest at the end of the clorazepate periods, regardless of the order of treatments. After diazepam, both diazepam and N-desmethyldiazepam (nordiazepam) were detected in blood, and after clorazepate, only N-desmethyldiazepam was detected. N-Desmethyldiazepam concentrations were higher after clorazepate. Clinical progress was apparently related to the concentration of N-desmethyldiazepam in plasma.

Type
Research Article
Information
Psychological Medicine , Volume 4 , Issue 4 , November 1974 , pp. 388 - 392
Copyright
Copyright © Cambridge University Press 1974

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Aitken, R. C. B. (1969). Measurement of feelings using Visual analogue scales. Proceedings of the Royal Society of Medicine, 62, 989–993.CrossRefGoogle ScholarPubMed
Boehringer Ingelheim Ltd. (1973). Tranxene. Product Data Sheet. Boehringer Ingelheim: Bracknell.Google Scholar
Charalampous, K. D., Tooley, W., and Yates, C. (1973). Clorazepate dipotassium: a new benzodiazepine antianxiety agent. Journal of Clinical Pharmacology, 13, 114–118.Google ScholarPubMed
Cooper, A. J., Magnus, R. V., Rose, M., Phanjoo, A., Lancaster, N. P., Pollard, P., and Knowlson, P. (1973). Controlled trial of dipotassium Clorazepate (‘Tranxene’) in anxiety. (Abstract.) British Journal of Psychiatry, 123, 475–476.CrossRefGoogle ScholarPubMed
de Silva, J. A. F., and Puglisi, C. V. (1970). Determination of medazepam (Nobrium), diazepam (Valium) and their major biotransformation products in blood and urine by electron capture gas-liquid chromatography. Analytical Chemistry, 42, 1725–1736.CrossRefGoogle Scholar
Holmberg, G., and Livstedt, B. (1972). Clinical evaluation of a new benzodiazepine derivative, Clorazepate. Arzneimittel-Forschung, 22, 916–919.Google Scholar
Kellner, R., Kelly, A. V., and Sheffield, B. F. (1968). The assessment of changes in anxiety in a drug trial: a comparison of methods. British Journal of Psychiatry, 114, 863–869.CrossRefGoogle Scholar
Kellner, R., and Sheffield, B. F. (1967). Symptom rating test scores in neurotics and normals. British Journal of Psychiatry, 113, 525–526.CrossRefGoogle ScholarPubMed
Randall, L. O., and Kappell, B. (1973). Pharmacological activity of some benzodiazepines and their metabolites. In The Benzodiazepines, pp. 27–51. Edited by Garattini, S., Mussini, E., and Randall, L. O.. Raven Press: New York.Google Scholar
Schwartz, M. A. (1973). Pathways of metabolism of the benzodiazepines. In The Benzodiazepines, pp. 53–74. Edited by Garattini, S., Mussini, E. and Randall, L. O.. Raven Press: New Nork.Google Scholar
Schwartz, M. A., and Postma, E. (1966). Metabolic N-demethylation of chlordiazepoxide. Journal of Pharmaceutical Sciences, 55, 1358–1362.CrossRefGoogle Scholar
Siegel, S. (1956). Nonparametric Statistics for the Behavioral Sciences. McGraw-Hill: New York.Google Scholar
Sternbach, L. H. (1973). Chemistry of 1,4-benzodiazepines and some aspects of the structure-activity relationship. In The Benzodiazepines, pp. 1–26. Edited by Garattini, S., Mussini, E., and Randall, L. O.. Raven Press: New York.Google Scholar
Zeally, A. K., and Aitken, R. C. B. (1969). Measurement of mood. Proceedings of the Royal Society of Medicine, 62, 993–996.CrossRefGoogle Scholar
Zingales, I. A. (1973). Diazepam metabolism during chronic medication. Unbound fraction in plasma, erythrocytes and urine. Journal of Chromatography, 75, 55–78.Google Scholar