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Biological component of the NIMH Clinical Research Branch Collaborative Program on the psychobiology of depression: II. Methodology and data analysis

  • Steven Secunda, Stephen H. Koslow (a1), D. Eugene Redmond (a2), David Garver (a3), T. Alan Ramsey (a4), Jack Croughan (a5), James Kocsis (a6), Israel Hanin (a7), Kenneth Lieberman (a8) and Regina Casper (a9)...


A preceding paper has reviewed the history, background, and rationale for this collaborative effort exploring the biologic basis of the affective disorders. This paper details the ‘flow’ of a subject through the experimental protocol, the instrumentation used to obtain the clinical and behavioural data, and the biologic methodologies employed in the analysis of the body fluids. Data management and analysis techniques developed for this study are also examined.


Corresponding author

1Address for correspondence: Dr Steven Secunda, 1050 Baltimore Pike, Springfield, Pennsylvania 19064, USA.


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American Psychiatric Association (1979). Diagnostic and Statistical Manual (third edn). Washington, D.C.
Anton-Tay, F. & Wurtman, R. J. (1971). Brain monoamines and endocrine functions. In Frontiers in Neuroendocrinology (ed. Martini, L. and Ganong, W. F.), pp. 4566. Oxford University Press: New York.
Axelrod, J. & Cohn, C. K. (1971). Methyltransferase enzymes in red blood cells. Journal of Pharmacology and Experimental Therapeutics 176, 650.
Axelrod, J. & Tomchick, R. (1958). Enzymatic O-methylation of epinephrine and other catechols. Journal of Biological Chemistry 233 702.
Baldessarini, R. J. (1975). The basis for amine hypothesis in affective disorders. Archives of General Psychiatry 32, 10871093.
Beckmann, H. & Goodwin, F. K. (1975). Antidepressant response to tricyclics and urinary MHPG in unipolar patients: clinical response to imipramine or amitriptyline. Archives of General Psychiatry 32, 1721.
Beisel, W. R., Cos, J. J., Horton, R., Ping, Y. C. & Forsham, P. H. (1964). Physiology of urinary cortisol excretion. Journal of Endocrinology and Metabolism 24, 887893.
Berson, S. A. & Yalow, R. S. (1978). Radioimmunoassay of ACTH in plasma. Journal of Clinical Investigation 47, 27252751.
Biggs, J. T., Holland, W. H., Chang, S., Hipps, P. P. & Sherman, W. R. (1976). The electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasma. Journal of Pharmaceutical Sciences 65, 261268.
Bivens, C. H., Lebovitz, H. & Feldman, J. (1973). Inhibition of hypoglycemia-induced growth hormone secretion by serotonin antagonists. New England Journal of Medicine 289, 236239.
Blackard, W. G. & Heidingsfelder, J. (1968). Adrenergic receptor control reclamia of growth hormone secretion. Journal of Clinical Investigation 47, 14071414.
Bockar, J., Rotte, R. & Heninger, G. (1974). Increased human platelet MAO activity during Li2CO3 therapy. Life Sciences 15, 21092118.
Bond, P. A., Jenner, F. A. & Sampson, G. A. (1972). Daily variations of the urine content of 3-methyoxy-4-hydroxyphenylglycol in two manic-depressive patients. Psychological Medicine 2, 81.
Bonsnes, R. W. & Taussky, H. H. (1945). On the colormetric determination of creatinine by the jaffee reaction. Journal of Biological Chemistry 158, 581591.
Boyd, A. E., Lebovitz, H. & Pfeiffer, J. (1970). Stimulation of human growth hormone secretion by L-dopa. New England Journal of Medicine 283, 14251429.
Breese, G. R., Prange, A. J., Howard, J. L., Lipton, M. A., McKinney, W. T., Bowman, R. E. & Bushnell, P. (1972). 3-Methoxy-4-hydroxyphenylglycol excretion and behavioral changes in rat and monkey after central sympathectomy with 6-hydroxydopamine. Nature: New Biology 240, 286287.
Briggs, M. & Briggs, M. (1973). Hormonal influences on erythrocyte catechol-O-methyltransferase activity in humans. Experentia 20, 278280.
Brown, J. B. (1977). Platelet MAO and alcoholism. American Journal of Psychiatry 134, 206207.
Brunswick, D. J. & Mendels, J. (1977). Reduced levels of tricyclic antidepressants in plasma from vacutainers. Communications and Psychopharmacology 1, 131134.
Bunney, W. E. Jr & Davis, J. M. (1965). Norepinephrine in depressive reactions: review. Archives of General Psychiatry 13, 483.
Burdock, E. I., Hakerem, G., Hardesty, A. S. & Zubin, J. (1960). A ward behavior rating scale for use with mental hospital patients. Journal of Clinical Psychology 16, 246247.
Burrows, G. D., Davies, B., Norman, T., Maguire, K. & Scoggins, B. A. (1978). Should plasma level monitoring of tricyclic antidepressants be introduced in clinical practice? Communications and Psychopharmacology 2, 393408.
Cade, J. F. J. (1964). A significant elevation of plasma Mg levels in schizophrenic and depressive states. Medical Journal of Australia i, 195196.
Caldwell, P. C., Hodgkin, A. L., Keynes, D. & Shaw, T. I. (1960). The effects of injecting ‘energy-rich’ phosphate compounds on the active transport of ions in the giant axons of loligo. Journal of Physiology (London) 152, 561590.
Carlsson, A., Carrodi, H., Fuxe, K. & Hokfelt, T. (1969). Effects of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-a-ethyl-m-tyramine. European Journal of Pharmacology 5, 357.
Carpenter, W. T., Murphy, D. L. & Wyatt, R. J. (1975). Platelet MAO activity in acute schizophrenia. American Journal of Psychiatry 132, 438441.
Carroll, B. J. (1972 a). Poor response to antidepressants and dexamethasone nonsuppression. In Depressive Illness: Some Research Studies (ed. Davies, B., Carroll, B. J. and Mowbray, R. M.), pp. 149201. C. C. Thomas: Springfield, Illinois.
Carroll, B. J. (1972 b). The hypothalamic–pituitary–adrenal axis in depression. In Depressive Illness: Some Research Studies (ed. Davies, B., Carroll, B. J. and Mowbray, R. M.), p. 23. C. C. Thomas: Springfield, Illinois.
Carroll, B. J. & Mendels, J. (1976). Neuroendocrine regulation in affective disorders. In Hormones, Behavior and Psychopathology (ed. Sachar, E. J.), pp. 193224. Raven Press: New York.
Casper, R. C., Davis, J. M., Pandey, G. N., Garver, D. L. & Dekirmenjian, H. (1977). Neuroendocrine and aminestudies in affective illness. Psychoneuroendocrinology 2, 105113.
Ching, J., Katz, M. M. & Sanborn, K. O. (1975). C–K–S Video Interview Rating Scale. Unpublished manuscript.
Cochran, E., Carl, J., Hanin, I., Koslow, S. & Robins, E. (1978). Effect of vacutainer stoppers on plasma tricyclic levels: A reevaluation. Communications and Psychopharmacology 2, 493503.
Cohn, C. K., Dunner, D. L. & Axelrod, J. (1970). Reduced catechol-O-methyl-transferase activity in red blood cells of women with primary affective disorder. Science 170, 1323.
Coppen, A., Montgomery, S., Ghose, K., Rama Rao, V. A., Bailey, J., Christiansen, S. J., Mikkleson, P. L., van Praag, H. M., van de Poel, F., Minsker, E. J., Kozulja, V. J., Matussek, N., Kungkunz, G. & Jorgensen, A. (1978). Amitriptyline plasma-concentration and clinical effect. Lancet i, 6366.
Cotham, R. H. & Shand, D. (1975). Spuriously low plasma propranolol concentrations resulting from blood collection methods. Clinical Pharmacology and Therapeutics 18, 535538.
Davis, J. M., Janowsky, D. S. & Elyousef, K. (1973). Pharmacology – the biology of lithium. In Lithium – Its Role in Psychiatric Research and Treatment (ed. Gershon, S. and Shopsin, B.), pp. 167188. Plenum Press: New York.
Dekirmenjian, H. & Maas, J. W. (1970). An improved procedure of 3-methyoxy-4-hydrophenylethylene glycol determination by gas–liquid chromatography. Analytical Biochemistry 35, 113122.
Derogatis, L. R., Lipman, R. S., Rickels, K., Uhlenhuth, E. H. & Covi, L. (1974). The Hopkins Symptom Checklist (HSCL): a measure of primary symptom dimensions. In Psychological Measurements in Psychopharmacology: Modern Problems in Pharmacopsychiatry Vol. 7 (ed. Pichot, P.), pp. 79110. S. Karger: Basel.
Donald, R. A. (1968). Application of the coated charcoal separation method to the RIA of plasma corticotrophin. Journal of Endocrinology 41, 499508.
Dunner, D. L., Cohn, C. K., Gershon, S. & Goodwin, F. K. (1971). Differential catechol-O-methyltransferase activity in unipolar and bipolar affective illness. Archives of General Psychiatry 25, 348.
Durell, J. (1974). Factors in depression. Sodium and potassium metabolism. In Lithium Salts and Affective Disorders. Raven Press: New York.
Endicott, J. & Spitzer, R. L. (1978). The schedule for affective disorders and schizophrenia. Archives of General Psychiatry 35, 837844.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A. Jr, Winokur, G. & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 5763.
Frazer, A., Secunda, S. & Mendels, J. (1972). A method for the determination of sodium, potassium, magnesium, and lithium concentration in erythrocytes. Clinica chimica acta 36, 499509.
Frazer, A., Mendels, J. & Brunswick, D. (1977 a). Transfer of lithium ions across the erythrocyte membrane. Communications and Psychopharmacology 1, 255270.
Frazer, A., Mendels, J., Brunswick, D. & Ramsey, T. A. (1977 b). Transfer of sodium ions across the erythrocyte membrane in manic-depressive illness: treatment with lithium carbonate. Life Sciences 22 (2), 157164.
Fremstad, D. & Bergerud, K. (1976). Plasma protein binding of drugs as influenced by blood collection methods. Acta pharmacologica et toxicologica 39, 570572.
Fri, C. G., Wiesel, F. A. & Sedval, G. (1974). Simultaneous quantification of homovanillic acid and 5-hydroxyindole- acetic acid in cerebrospinal fluid by mass fragmentography. Life Sciences 14, 24692480.
Friedman, E., Shopsin, B., Sathananthan, G. & Pershon, S. (1974). Blood platelet MAO activity in psychiatric patients. American Journal of Psychiatry 131, 13921394.
Frizel, D., Coppen, A. J. & Marks, V. (1969). Plasma magnesium and calcium in depression. British Journal of Psychiatry 115, 13751377.
Furlong, F. W., Sellers, E. M. & Kapur, B. M. (1977). Amitryptyline blood levels and relapse. Canadian Psychiatric Association Journal 22, 275284.
Garrahan, P. J. & Glynn, I. M., (1967). The stoichiometry of the sodium pump. Journal of Physiology (London) 192, 217235.
Garver, D. L., Pandey, G. N., Dekirmenjian, H. & Deleon-Jones, F. (1975). Growth hormone and catecholamines in affective disease. American Journal of Psychiatry 132, 11491154.
Gibbons, J. L. (1960). Total body sodium and potassium in depressive illness. Clinical Science 19, 133.
Glowinski, J., Kolpin, I. J. & Axelrod, J. (1965). Metabolism of [3H]-norepinephrine in rat brain. Journal of Neurochemistry 12, 2530.
Goodwin, F. K. & Post, R. M. (1975). Studies of amine metabolites in affective illness in schizophrenia: a comparative analysis. In Biology of Major Psychosis: A Comparative Analysis (ed. Freedman, D. X.), pp. 299332. Raven Press: New York.
Gram, L. F. (1977). Plasma level monitoring of tricyclic antidepressant therapy. Clinical Pharmacokinetics 2, 237251.
Greenspan, K., Schildkraut, J. J., Gordon, E. K., Baer, L., Aranoff, M. S. & Durell, J. (1970). Catecholamine metabolism in affective disorders. III. MHPG and other catecholamine metabolites in patients treated with lithium carbonate. Journal of Psychiatric Research 7, 171.
Gruen, P. H., Sachar, E. J., Altman, N. & Sassin, J. (1975). Growth hormone responses to hypoglycemia in post-menopausal, depressed women. Archives of General Psychiatry 32, 3133.
Gustavson, K. H., Wetterberg, L., Backstrom, M. & Ross, S. F. (1973). COMT activity in erythrocytes in Down's syndrome. Clinical Genetics 4, 279280.
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 5662.
Hamilton, M. (1967). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278296.
Himsworth, R. (1970). Hypothalamic control of adrenalin secretion in response to insufficient glucose. Journal of Physiology 206, 411417.
Hoggerty, G. (1974). Personal history for depressive disorders (PHDD). Unpublished manuscript.
Hokin-Neaverson, M., Burckhardt, W. A. & Jefferson, J. (1976). Increased erythrocyte NA+ pump and NaKATPase activity during lithium therapy. Research Communications in Chemical Pathology and Pharmacology 14, 117126.
Imura, H., Lal, S., de la Vega, C. E., Sourkes, T. L. & Friesen, H. G. (1973). Effect of apomorphine on growth hormone prolactin, luteinizing hormone and follicle-stimulating hormone, levels in human serum. Journal of Clinical Endocrinology and Metabolism 37, 719724.
Jones, F. D., Maas, J. W., Dekirmenjian, H. & Fawcett, J. A. (1973). Urinary catecholamine metabolites during behavioral changes in a patient with manic-depressive cycles. Science 179, 300.
Katz, M. M. & Itil, T. M. (1974). Video methodology for research in psychopathology and psychopharmacology. Archives of General Psychiatry 31, 204210.
Katz, M. M., Secunda, S. K., Hirschfeld, R. M. A. & Koslow, S. H. (1979). NIMH Clinical Research Branch Collaborative Program on the psychobiology of depression. Archives of General Psychiatry 36, 765771.
King, H. E. (1972). Tests of motility relevant to the affective disorders. Special Report for the Clinical Research Branch of NIMH. Unpublished manuscript.
Lal, S., Tolis, G., Martin, J. B., Brown, G. M. & Guyda, H. (1975). Effect of clonidine on growth hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and thyroid-stimulating hormone in the serum of normal men. Journal of Clinical Endocrinology and Metabolism 41, 827831.
Liotta, A. & Krieger, D. T. (1975). A sensitive bioassay for the determination of human plasma ACT levels. Journal of Clinical Endocrinology and Metabolism 40, 268277.
Maas, J. W. (1975). Biogenic amines and depression. Archives of General Psychiatry 32, 13571361.
Maas, J. W. (1977). The effects of psychopharmacological agents on central nervous system amine metabolism in man. Annual Review of Pharmacology 17, 411424.
Maas, J. W. & Landis, D. H. (1965). Brain norepinephrine and behavior: a behavioral study and kinetic study. Psychosomatic Medicine 27, 399407.
Maas, J. W. & Landis, D. H. (1968). In vivo studies of the metabolism of norepinephrine in the central nervous system. Journal of Pharmacology and Experimental Therapeutics 163, 147162.
Maas, J. W. & Landis, D. H. (1971). The metabolism of circulating norephinephrine by human subjects. Journal of Pharmacology and Experimental Therapeutics 177, 600612.
Maas, J. W., Fawcett, J. A. & Dekirmenjian, H. (1968a). 3-Methoxy-4-hydroxy-phenylglycol (HMPG) excretion in depressive states. pilot study. Archives of General Psychiatry 19, 129.
Maas, J. W., Fawcett, J. A. & Dekirmenjian, H. (1968 b). 3-Methoxy-4-hydroxy-phenylglycol (MHPG) excretion in depressed states. Archives of General Psychiatry 19, 129134.
Maas, J. W., Fawcett, J. A. & Dekirmenjian, H. (1972). Catecholamine metabolism, depressive illness and drug response. Archives of General Psychiatry 26, 252.
Maas, J. W., Dekirmenjian, H., Garver, D., Redmond, D. E. & Landis, D. H. (1973 a). Excretion of catecholamine metabolites following intraventricular injection of 6-hydroxy-dopamine in the Macaca Speciosa. European Journal of Pharmacology 23, 121130.
Maas, J. W., Dekirmenjian, H. & Jones, F. (1973 b) The identification of depressed patients who have a disorder of NE metabolites and/or disposition. In Frontiers in Catecholamine Research (ed. Usdin, E. and Snyder, S. H.), pp. 10911096. Pergamon Press: New York.
Maas, J. W., Koslow, S., Davis, J., Katz, M., Mendels, J., Robins, E., Stokes, P. & Bowden, C. (1980). Biological component of the NIMH Clinical Research Branch Collaborative Program on the psychobiology of depression. I. Background and theoretical considerations. Psychological Medicine 10, 759776.
Martin, J. B. (1973). Neural regulation of growth hormone secretion. New England Journal of Medicine 288, 13841393.
Matthysse, S. & Baldessarini, R. J. (1972). S-adenosylmethionine and catechol-O-methyl-transferase in schizophrenia. American Journal of Psychiatry 128, 13101312.
Meltzer, H. Y. & Stahl, S. M. (1974). Platelet MAO activity and substrate preferences in schizophrenic patients. Research Communications in Chemical Pathology and Pharmacology 7, 419431.
Mendels, J. & Frazer, A. (1974). Alterations in cell membrane activity in depression. American Journal of Psychiatry 131, 12401246.
Muller, E. E., Sawane, S., Arimura, A. & Schally, A. V. (1967). Blockade of release of growth hormone by brain norepinephrine depletors. Endocrinology 80, 471476.
Muller, P. S., Heninger, G. R. & McDonald, R. K. (1969). Insulin tolerance test in depression. Archives of General Psychiatry 21, 587594.
Murphy, B. E. P. (1967). Some studies of the protein binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in the body fluids by competitive protein-binding radioassay. Journal of Clinical Endocrinology and Metabolism 27, 973990.
Murphy, D. L. & Redmond, D. E. Jr (1965). The catecholamines: possible role in affect, mood, and emotional behavior in man and animals. In Catecholamines and Behavior Vol. 2 (ed. Friedhoff, J. A.), pp. 17117. Plenum Press: New York.
Murphy, D. L. & Weiss, R. (1972). Reduced MAO activity in blood platelets from bipolar depressed patients. American Journal of Psychiatry 128, 13511357.
Murphy, D. L. & Wyatt, R. J. (1972). Reduced MAO activity in blood platelets from schizophrenic patients. Nature 238, 225226.
Murphy, D. L., Campbell, I. & Costa, J. L. (1978). Current status of the indoleamine hypothesis of the affective disorders. In Psychopharmacology: A Generation of Progress (ed. Lipton, M. A., Dimascio, A. and Killam, K. F.), pp. 12351247. Raven Press: New York.
Murphy, D. L., Pickar, D. & Alterman, I. S. (1980). Methods for the quantitative assessment of depressive and manic behavior. In Quantitative Techniques for the Evaluation of the Behavior of Psychiatric Patients (ed. Burdock, E. I., Sudilovsky, A. and Gershon, S.). Marcel-Dekker: New York (in the press).
Nies, A., Robinson, D. S., Amborn, K. R. & Lampert, R. P. (1973). Genetic control of platelet and plasma MAO activity. Archives of General Psychiatry 28, 834838.
Pandey, G. N., Dorus, E. B., Dekirmenjian, H. & Davis, J. M. (1975). Effect of Li treatment on blood COMT and platelet MAO in normal human subjects. Federation Proceedings; Federation of American Societies for Experimental Biology 34, 778.
Piemonte, G., Luisetto, G. & Conte, N. (1973). A simplified method to determine ultra-filterable plasma magnesium. Normal values and preliminary results in hyper and hypothyroidism. Clinica chimica acta 45, 261267.
Post, R. L., Albright, C. D. & Dayain, K. (1967). Resolution of pump and leak components of Na+ and K+ ion transport in human erythrocytes. Journal of General Physiology 50, 12011220.
Raskin, A., Schulterbrandt, J. G., Reatig, N. & McKeon, J. J. (1969). Replication of factors of psychopathology in interview, ward behavior, and self-ratings of hospitalized depressives. Journal of Nervous and Mental Disease 148, 8798.
Rybakowski, J., Chtopocka, M., Kapelski, Z., Hernacka, B., Szaynerman, Z. & Kasprzak, K. (1974). Red blood cell lithium index in patients with affective disorders in the course of lithium prophylaxis. International Pharmacopsychiatry 9, 166171.
Sachar, E., Finkelstein, J. & Hellman, J. (1971). Growth hormone responses in depressive illness. I. Response to insulin tolerance test. Archives of General Psychiatry 25, 263269.
Sachar, E., Mushrush, G., Perlow, M., Weitzman, E. & Sassin, J. (1972). Growth hormone response in L-dopa in depressed patients. Science 178, 13041305.
Sachar, E., Frantz, A. G., Altman, N. & Sassin, J. (1973). Growth hormone and prolactin in unipolar and bipolar depressed patients: responses to hypoglycemia and L-dopa. American Journal of Psychiatry 130, 13621367.
Schildkraut, J. J. (1965). The catecholamine hypothesis of affective disorders: a review of supporting evidence. American Journal of Psychiatry 122, 509.
Schildkraut, J. J. (1973). Norepinephrine metabolites as biochemical criteria for classifying depressive disorders and predicting responses to treatment: preliminary findings. American Journal of Psychiatry 130, 695699.
Schildkraut, J. J. (1978). Current status of the catecholamine hypothesis of affective disorders. In Psychopharmacology: A Generation of Progress (ed. Lipton, M. A., DiMascio, A. and Killam, K. F.), pp. 12231234. Raven Press: New York.
Schildkraut, J. J. & Kety, S. S. (1967). Biogenic amines and emotion. Science 156, 21.
Schildkraut, J. J., Draskoczy, P. R., Gershon, E. S., Reich, P. & Grab, E. L. (1971). Effects of tricyclic antidepressants on norepinephrine metabolism: basis and clinical studies.In Brain Chemistry and Mental Disease (ed Ho, B. T. and McLsaac, W.), pp. 215236. Plenum Press: New York.
Shaskan, E. G. & Becker, R. E. (1975). Platelet MAO in schizophrenics. Nature 259, 659660.
Simhchari, N., Leiner, K. & Brown, C. (1975). The simultaneous determination by selected ion monitoring of the levels of homovanillie, isohomovanillie, 3, 4-dihydroxy-phenylacetic acid and 3-methoxy-4-hydroxymandelic acid in simple biological samples. Clinica chimica acta 62, 245253.
Skou, J. C. (1960). Further investigations on a Mg+ Na+ activated ATPase, possibly related to the active, linked transport of Na+ and K+ across the nerve membrane. Biochemica et biophysica acta 42, 6.
Spitzer, R. L. & Endicott, J. (1978). Schedule of Affective Disorders and Schizophrenia–Change Version (third edn). Biometrics Research, New York State Psychiatric Institute: New York.
Spitzer, R. L., Endicott, J. & Robins, E. (1975). Clinical criteria for psychiatric diagnosis and DSM-III. American Journal of Psychiatry 132, 11871192.
Spitzer, R. L., Endicott, J. & Robins, E. (1978 a). Research Diagnostic Criteria (RDC) For a Selected Group of Functional Disorders (third edn). Biometrics Research, New York State Psychiatric institute: New York. Developed by Spitzer, J., Endicott, E. Robins with the assistance of the other participants in the NIMH Clinical Research Branch Collaborative Program on the Psychobiology of Depression.
Spitzer, R. L., Endicott, J. & Robins, E. (1978 b). Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry 35, 773782.
Stokes, P. E. (1972). Studies on the control of adrenocortical function in depression. In Recent Advances in the Psychobiology of the Depressive Illnesses (ed. Williams, T., Katz, M. and Shield, J. A. Jr), pp. 199200. DHEW Publication 70–9053. US Government Printing Office: Washington, D.C.
Stokes, P. E., Stoll, P. M., Mattson, M. D. & Sollod, R. N. (1976). Diagnosis and psychopathology in psychiatric patients resistant to dexamethasone. In Hormones, Behavior and Psychopathology (ed. Sachar, E. J.), pp. 225232. Raven Press: New York.
Swahn, O. G., Sandgarde, B., Wiesel, F. A. & Sedvall, G. (1976). Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method. Psychopharmacology 48, 147152.
Taniguchi, K., Kaimoto, Y. & Armstrong, M. D. (1964). Quantitative determination of metaephrine and normetanephrine in urine. Journal of Laboratory and Clinical Medicine 64, 469484.
Weinshilboum, R. M., Raymond, F. A., Elveback, L. R. & Weidman, W. H. (1974). Correlation of erythrocyte catechol-O-methyltransferase activity between siblings. Nature 252, 490491.
Wilkinson, G. R. & Schenker, S. (1976). Letter to the editor. Clinical Pharmacology and Therapeutics 19, 486488.
Zeller, E. A. (1975). Molecular abenation in platelet MAO in schizophrenia. Lancet i, 1385.
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