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Antipsychotic drugs: is more worse? a meta-analysis of the published randomized control trials

Published online by Cambridge University Press:  09 July 2009

P. Bollini ,
S. Pampallona ,
M. J. Orza ,
M. E. Adams  and
T. C. Chalmers
P. Bollini*
Affiliation:
Technology Assessment Group, Harvard School of Public Health, Boston, MA., USA
S. Pampallona
Affiliation:
Technology Assessment Group, Harvard School of Public Health, Boston, MA., USA
M. J. Orza
Affiliation:
Technology Assessment Group, Harvard School of Public Health, Boston, MA., USA
M. E. Adams
Affiliation:
Technology Assessment Group, Harvard School of Public Health, Boston, MA., USA
T. C. Chalmers
Affiliation:
Technology Assessment Group, Harvard School of Public Health, Boston, MA., USA
*
1 Address for correspondence: Dr Paola Bollini, I.O.M., 17 Route des Morillons, 1211 Geneva, Switzerland
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Synopsis

Effectiveness and side-effects of high- versus low-dose neuroleptic treatment of chronic psychosis have been assessed through a meta-analysis of 22 published randomized control trials comparing different neuroleptic doses. No incremental clinical improvement was found at doses above 375 mg equivalent of chlorpromazine, while a significant increase in adverse reactions was observed.

Type
Original Articles
Information
Psychological Medicine , Volume 24 , Issue 2 , May 1994 , pp. 307 - 316
Copyright
Copyright © Cambridge University Press 1994

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