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Altered resting-state cerebellar-cerebral functional connectivity in obsessive-compulsive disorder

  • Tingting Xu (a1), Qing Zhao (a1), Pei Wang (a1), Qing Fan (a1), Jue Chen (a1), Haiyin Zhang (a1), Zhi Yang (a1), Dan J. Stein (a2) and Zhen Wang (a1) (a3)...



The role of the cerebellum in obsessive-compulsive disorder (OCD) has drawn increasing attention. However, the functional connectivity between the cerebellum and the cerebral cortex has not been investigated in OCD, nor has the relationship between such functional connectivity and clinical symptoms.


A total of 27 patients with OCD and 21 healthy controls (HCs) matched on age, sex and education underwent magnetic resonance imaging (MRI). Seed-based connectivity analyses were performed to examine differences in cerebellar-cerebral connectivity in patients with OCD compared with HCs. Associations between functional connectivity and clinical features in OCD were analyzed.


Compared with HCs, OCD patients showed significantly decreased cerebellar-cerebral functional connectivity in executive control and emotion processing networks. Within the OCD group, decreased functional connectivity in an executive network spanning the right cerebellar Crus I and the inferior parietal lobule was positively correlated with symptom severity, and decreased connectivity in an emotion processing network spanning the left cerebellar lobule VI and the lingual gyrus was negatively correlated with illness duration.


Altered functional connectivity between the cerebellum and cerebral networks involved in cognitive-affective processing in patients with OCD provides further evidence for the involvement of the cerebellum in the pathophysiology of OCD, and is consistent with impairment in executive control and emotion regulation in this condition.


Corresponding author

Author for correspondence: Zhen Wang, E-mail:,


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These authors contributed equally to this work and should be considered co-first authors



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Altered resting-state cerebellar-cerebral functional connectivity in obsessive-compulsive disorder

  • Tingting Xu (a1), Qing Zhao (a1), Pei Wang (a1), Qing Fan (a1), Jue Chen (a1), Haiyin Zhang (a1), Zhi Yang (a1), Dan J. Stein (a2) and Zhen Wang (a1) (a3)...


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