Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-18T01:26:38.131Z Has data issue: false hasContentIssue false
  • English
  • Français

Activity in chronic schizophrenic patients: comparison of pimozide with fluphenazine in a double blind trial

Published online by Cambridge University Press:  09 July 2009

A. C. P. Sims  and
I. G. Burnside
A. C. P. Sims
Affiliation:
From All Saints' Hospital, Birmingham
I. G. Burnside
Affiliation:
From All Saints' Hospital, Birmingham
Get access Rights & Permissions [Opens in a new window]

Synopsis

A double-blind crossover trial was carried out comparing pimozide with fluphenazine. The effects of the drugs on the activity of 20 chronic inert male schizophrenic patients were measured using nursing observations, psychiatric rating, and an operant conditioning method. When activity was assessed in these different ways, no significant difference was found between the two drugs on any of the measures. It is concluded that pimozide does not effectively increase the activity in such patients. It is considered that the free operant conditioning method used was shown to be a useful measure for comparing therapy in chronic schizophrenic patients.

Type
Original Article
Information
Psychological Medicine , Volume 5 , Issue 2 , May 1975 , pp. 161 - 164
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cheadle, A. J., Cushing, D., Drew, C. D. A., and Morgan, R. (1967). The measurement of the work performance of psychiatric patients. British Journal of Psychiatry, 113, 841–846.CrossRefGoogle ScholarPubMed
Ferster, C. B., and Skinner, B. F. (1957). Schedules of Reinforcement. Appleton-Century-Crofts: New York.CrossRefGoogle ScholarPubMed
Honigfeld, G., and Klett, C. J. (1965). The nurses' observation scale for inpatient evaluation: a new scale for measuring improvement in chronic schizophrenia. Journal of Clinical Psychology, 21, 65–71.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Janssen, P. A. J., Niemegeers, C. J. E., Schellekens, K. H. L., Dresse, A., Lenaerts, F. M., Pinchard, A., Schaper, W. K. A., Nueten, J. M., and Verbruggen, F. J. (1968). Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. Arzneimittel-Forsch 18, 261–279.Google ScholarPubMed
Lindlsey, O. R. (1956). Operant conditioning methods applied to research in chronic schizophrenia. Psychiatric Research Reports, 5, 118–139.Google Scholar
Lindsley, O. R. (1960). Characteristics of the behavior of chronic psychotics as revealed by free-operant conditioning methods. Diseases of the Nervous System, 21, (2), Suppl., 66–78.Google Scholar
Morris, P. A., Mackenzie, D. H., and Masheter, H. C. (1970). A comparative double blind trial of pimozide and fluphenazine in chronic schizophrenia. British Journal of Psychiatry, 117, 683–684.CrossRefGoogle ScholarPubMed
Smythies, J. R. (1971). The mechanism of action of drugs used in the treatment of schizophrenia. Clinical Trials Journal, 8, Suppl. 2, 9–18.Google Scholar
Sterkmans, P., Brugmans, J., and Gevers, F. (1968). The clinical efficacy of pimozide in chronic psychotic patients. Clinical Trials Journal, 5, 1107–1112.Google Scholar