Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
  • Home
Hostname: page-component-559fc8cf4f-z4vvc Total loading time: 0.412 Render date: 2021-03-05T08:19:59.609Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }
EnglishFrançais
Psychological Medicine Psychological Medicine

Article contents

Selective functional disconnection of the orbitofrontal subregions in schizophrenia

Published online by Cambridge University Press:  10 February 2017

Y. Xu ,
W. Qin ,
C. Zhuo ,
L. Xu ,
J. Zhu ,
X. Liu  and
C. Yu
Y. Xu
Affiliation:
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China Department of Computed Tomography and Magnetic Resonance Imaging, Handan First Hospital, Handan, Hebei, China
W. Qin
Affiliation:
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
C. Zhuo
Affiliation:
Tianjin Anning Hospital, Tianjin, China
L. Xu
Affiliation:
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
J. Zhu
Affiliation:
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
X. Liu
Affiliation:
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
C. Yu
Affiliation:
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
Corresponding
E-mail address:
chunshuiyu@vip.163.com
Get access
Rights & Permissions[Opens in a new window]

Abstract

Background

As a disconnection syndrome, schizophrenia has shown impaired resting-state functional connectivity (rsFC) in the orbitofrontal cortex (OFC); however, the OFC is a rather heterogeneous region and the rsFC changes in the OFC subregions remain unknown.

Method

A total of 98 schizophrenia patients and 102 healthy controls underwent resting-state functional MRI using a sensitivity-encoded spiral-in imaging sequence (SENSE-SPIRAL) to reduce susceptibility-induced signal loss and distortion. The OFC subregions were defined according to a previous parcellation study that divided the OFC into the anterior (OFCa), medial (OFCm), posterior (OFCp), intermediate (OFCi), and lateral (OFCl) subregions. The rsFC was compared using two-way repeated-measures ANOVA.

Results

Whether or not global signal regression, compared with healthy controls, schizophrenia patients consistently exhibited decreased rsFC between the left OFCi and the left middle temporal gyrus and the right middle frontal gyrus (MFG), between the right OFCi and the right MFG and the left inferior frontal gyrus, between the right OFCm and the middle cingulate cortex and the left Rolandic operculum. These rsFC changes still remained significant even after cortical atrophy correction.

Conclusions

These findings suggest a selective functional disconnection of the OFC subregions in schizophrenia, and provide more precise information about the functional disconnections of the OFC in this disorder.

Keywords

Magnetic resonance imaging orbitofrontal subregions resting-state functional connectivity schizophrenia sensitivity-encoded spiral-in imaging sequence
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 9 , July 2017 , pp. 1637 - 1646
Copyright
Copyright © Cambridge University Press 2017 

Access options

Get access to the full version of this content by using one of the access options below.
If you should have access and can't see this content please contact technical support.

Footnotes

†

These authors contributed equally to this work.

References

Andreasen, NC (2010). The lifetime trajectory of schizophrenia and the concept of neurodevelopment. Dialogues in Clinical Neuroscience 12, 409–415.Google ScholarPubMed
Andreasen, NC, Nopoulos, P, Magnotta, V, Pierson, R, Ziebell, S, Ho, BC (2011). Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biological Psychiatry 70, 672–679.CrossRefGoogle ScholarPubMed
Asami, T, Bouix, S, Whitford, TJ, Shenton, ME, Salisbury, DF, McCarley, RW (2012). Longitudinal loss of gray matter volume in patients with first-episode schizophrenia: DARTEL automated analysis and ROI validation. NeuroImage 59, 986–996.CrossRefGoogle ScholarPubMed
Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. NeuroImage 38, 95–113.CrossRefGoogle ScholarPubMed
Baare, WF, Hulshoff Pol, HE, Hijman, R, Mali, WP, Viergever, MA, Kahn, RS (1999). Volumetric analysis of frontal lobe regions in schizophrenia: relation to cognitive function and symptomatology. Biological Psychiatry 45, 1597–1605.CrossRefGoogle ScholarPubMed
Baas, D, Aleman, A, Vink, M, Ramsey, NF, de Haan, EH, Kahn, RS (2008). Evidence of altered cortical and amygdala activation during social decision-making in schizophrenia. NeuroImage 40, 719–727.CrossRefGoogle Scholar
Barch, DM, Ceaser, A. (2012). Cognition in schizophrenia: core psychological and neural mechanisms. Trends in Cognitive Sciences 16, 27–34.CrossRefGoogle Scholar
Behroozmand, R, Shebek, R, Hansen, DR, Oya, H, Robin, DA, Howard, MA III, Greenlee, JD (2015). Sensory-motor networks involved in speech production and motor control: an fMRI study. NeuroImage 109, 418–428.CrossRefGoogle Scholar
Brown, GG, Thompson, WK (2010). Functional brain imaging in schizophrenia: selected results and methods. Current Topics in Behavioral Neurosciences 4, 181–214.CrossRefGoogle ScholarPubMed
Chan, RC, Di, X, McAlonan, GM, Gong, QY (2011). Brain anatomical abnormalities in high-risk individuals, first-episode, and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progression. Schizophrenia Bulletin 37, 177–188.CrossRefGoogle ScholarPubMed
Dolan, MC, Fullam, RS (2009). Psychopathy and functional magnetic resonance imaging blood oxygenation level-dependent responses to emotional faces in violent patients with schizophrenia. Biological Psychiatry 66, 570–577.CrossRefGoogle ScholarPubMed
Dosenbach, NU, Fair, DA, Cohen, AL, Schlaggar, BL, Petersen, SE (2008). A dual-networks architecture of top-down control. Trends in Cognitive Sciences 12, 99–105.CrossRefGoogle ScholarPubMed
Ellison-Wright, I, Glahn, DC, Laird, AR, Thelen, SM, Bullmore, E (2008). The anatomy of first-episode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. American Journal of Psychiatry 165, 1015–1023.CrossRefGoogle ScholarPubMed
Fox, MD, Zhang, D, Snyder, AZ, Raichle, ME (2009). The global signal and observed anticorrelated resting state brain networks. Journal of Neurophysiology 101, 3270–3283.CrossRefGoogle ScholarPubMed
Guo, Q, Tang, Y, Li, H, Zhang, T, Li, J, Sheng, J, Liu, D, Li, C, Wang, J (2014 a). Both volumetry and functional connectivity of Heschl's gyrus are associated with auditory P300 in first episode schizophrenia. Schizophrenia Research 160, 57–66.CrossRefGoogle ScholarPubMed
Guo, S, Kendrick, KM, Yu, R, Wang, HL, Feng, J (2014 b). Key functional circuitry altered in schizophrenia involves parietal regions associated with sense of self. Human Brain Mapping 35, 123–139.CrossRefGoogle ScholarPubMed
Hammer, TB, Oranje, B, Skimminge, A, Aggernaes, B, Ebdrup, BH, Glenthoj, B, Baare, W (2013). Structural brain correlates of sensorimotor gating in antipsychotic-naive men with first-episode schizophrenia. Journal of Psychiatry & Neuroscience 38, 34–42.CrossRefGoogle ScholarPubMed
Herold, R, Feldmann, A, Simon, M, Tenyi, T, Kover, F, Nagy, F, Varga, E, Fekete, S (2009). Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: a voxel-based morphometric study. Acta Psychiatrica Scandinavica 119, 199–208.CrossRefGoogle ScholarPubMed
Hoptman, MJ, Antonius, D, Mauro, CJ, Parker, EM, Javitt, DC (2014). Cortical thinning, functional connectivity, and mood-related impulsivity in schizophrenia: relationship to aggressive attitudes and behavior. American Journal of Psychiatry 171, 939–948.CrossRefGoogle ScholarPubMed
Kahnt, T, Chang, LJ, Park, SQ, Heinzle, J, Haynes, JD (2012). Connectivity-based parcellation of the human orbitofrontal cortex. Journal of Neuroscience 32, 6240–6250.CrossRefGoogle ScholarPubMed
Kay, SR, Fiszbein, A, Opler, LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261–276.CrossRefGoogle Scholar
Kester, HM, Sevy, S, Yechiam, E, Burdick, KE, Cervellione, KL, Kumra, S (2006). Decision-making impairments in adolescents with early-onset schizophrenia. Schizophrenia Research 85, 113–123.CrossRefGoogle ScholarPubMed
Kim, DI, Sui, J, Rachakonda, S, White, T, Manoach, DS, Clark, VP, Ho, BC, Schulz, SC, Calhoun, VD (2010). Identification of imaging biomarkers in schizophrenia: a coefficient-constrained independent component analysis of the mind multi-site schizophrenia study. Neuroinformatics 8, 213–229.CrossRefGoogle ScholarPubMed
Kringelbach, ML (2005). The human orbitofrontal cortex: linking reward to hedonic experience. Nature Reviews Neuroscience 6, 691–702.CrossRefGoogle ScholarPubMed
Kringelbach, ML, Rolls, ET (2004). The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Progress in Neurobiology 72, 341–372.CrossRefGoogle ScholarPubMed
Liu, F, Xie, B, Wang, Y, Guo, W, Fouche, JP, Long, Z, Wang, W, Chen, H, Li, M, Duan, X, Zhang, J, Qiu, M, Chen, H (2015 a). Characterization of post-traumatic stress disorder using resting-state fMRI with a multi-level parametric classification approach. Brain Topography 28, 221–237.CrossRefGoogle ScholarPubMed
Liu, F, Zhuo, C, Yu, C (2016). Altered cerebral blood flow covariance network in schizophrenia. Frontiers in Neuroscience 10.CrossRefGoogle Scholar
Liu, H, Qin, W, Qi, H, Jiang, T, Yu, C (2015 b). Parcellation of the human orbitofrontal cortex based on gray matter volume covariance. Human Brain Mapping 36, 538–548.CrossRefGoogle ScholarPubMed
Lynall, ME, Bassett, DS, Kerwin, R, McKenna, PJ, Kitzbichler, M, Muller, U, Bullmore, E (2010). Functional connectivity and brain networks in schizophrenia. Journal of Neuroscience 30, 9477–9487.CrossRefGoogle Scholar
Mackey, S, Petrides, M (2010). Quantitative demonstration of comparable architectonic areas within the ventromedial and lateral orbital frontal cortex in the human and the macaque monkey brains. European Journal of Neuroscience 32, 1940–1950.CrossRefGoogle ScholarPubMed
Mandal, MK, Pandey, R, Prasad, AB (1998). Facial expressions of emotions and schizophrenia: a review. Schizophrenia Bulletin 24, 399–412.CrossRefGoogle ScholarPubMed
McIntosh, AM, Munoz Maniega, S, Lymer, GK, McKirdy, J, Hall, J, Sussmann, JE, Bastin, ME, Clayden, JD, Johnstone, EC, Lawrie, SM (2008). White matter tractography in bipolar disorder and schizophrenia. Biological Psychiatry 64, 1088–1092.CrossRefGoogle Scholar
Mullen, PE, Burgess, P, Wallace, C, Palmer, S, Ruschena, D (2000). Community care and criminal offending in schizophrenia. Lancet 355, 614–617.CrossRefGoogle Scholar
Naudts, K, Hodgins, S (2006). Schizophrenia and violence: a search for neurobiological correlates. Current Opinion in Psychiatry 19, 533–538.CrossRefGoogle ScholarPubMed
Ongur, D, Ferry, AT, Price, JL (2003). Architectonic subdivision of the human orbital and medial prefrontal cortex. Journal of Comparative Neurology 460, 425–449.CrossRefGoogle Scholar
Pettersson-Yeo, W, Allen, P, Benetti, S, McGuire, P, Mechelli, A (2011). Dysconnectivity in schizophrenia: where are we now? Neuroscience and Biobehavioral Reviews 35, 1110–1124.CrossRefGoogle ScholarPubMed
Power, JD, Barnes, KA, Snyder, AZ, Schlaggar, BL, Petersen, SE (2013). Steps toward optimizing motion artifact removal in functional connectivity MRI; a reply to Carp. NeuroImage 76, 439–441.CrossRefGoogle ScholarPubMed
Pruessmann, KP, Weiger, M, Scheidegger, MB, Boesiger, P (1999). SENSE: sensitivity encoding for fast MRI. Magnetic Resonance in Medicine 42, 952–962.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Pu, W, Rolls, ET, Guo, S, Liu, H, Yu, Y, Xue, Z, Feng, J, Liu, Z (2014). Altered functional connectivity links in neuroleptic-naive and neuroleptic-treated patients with schizophrenia, and their relation to symptoms including volition. NeuroImage. Clinical 6, 463–474.CrossRefGoogle ScholarPubMed
Sapara, A, Cooke, M, Fannon, D, Francis, A, Buchanan, RW, Anilkumar, AP, Barkataki, I, Aasen, I, Kuipers, E, Kumari, V (2007). Prefrontal cortex and insight in schizophrenia: a volumetric MRI study. Schizophrenia Research 89, 22–34.CrossRefGoogle ScholarPubMed
Scholvinck, ML, Maier, A, Ye, FQ, Duyn, JH, Leopold, DA (2010). Neural basis of global resting-state fMRI activity. Proceedings of the National Academy of Sciences USA 107, 10238–10243.CrossRefGoogle ScholarPubMed
Shad, MU, Keshavan, MS, Tamminga, CA, Cullum, CM, David, A (2007). Neurobiological underpinnings of insight deficits in schizophrenia. International Review of Psychiatry 19, 437–446.CrossRefGoogle Scholar
Su, TW, Lan, TH, Hsu, TW, Biswal, BB, Tsai, PJ, Lin, WC, Lin, CP (2013). Reduced neuro-integration from the dorsolateral prefrontal cortex to the whole brain and executive dysfunction in schizophrenia patients and their relatives. Schizophrenia Research 148, 50–58.CrossRefGoogle ScholarPubMed
Truong, TK, Song, AW (2008). Single-shot dual-z-shimmed sensitivity-encoded spiral-in/out imaging for functional MRI with reduced susceptibility artifacts. Magnetic Resonance in Medicine 59, 221–227.CrossRefGoogle ScholarPubMed
Von Der Heide, RJ, Skipper, LM, Klobusicky, E, Olson, IR (2013). Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis. Brain 136, 1692–1707.CrossRefGoogle Scholar
Wang, D, Zhou, Y, Zhuo, C, Qin, W, Zhu, J, Liu, H, Xu, L, Yu, C (2015). Altered functional connectivity of the cingulate subregions in schizophrenia. Translational Psychiatry 5, e575.CrossRefGoogle Scholar
Weissenbacher, A, Kasess, C, Gerstl, F, Lanzenberger, R, Moser, E, Windischberger, C (2009). Correlations and anticorrelations in resting-state functional connectivity MRI: a quantitative comparison of preprocessing strategies. NeuroImage 47, 1408–1416.CrossRefGoogle ScholarPubMed
Woodward, ND, Waldie, B, Rogers, B, Tibbo, P, Seres, P, Purdon, SE (2009). Abnormal prefrontal cortical activity and connectivity during response selection in first episode psychosis, chronic schizophrenia, and unaffected siblings of individuals with schizophrenia. Schizophrenia Research 109, 182–190.CrossRefGoogle ScholarPubMed
Wu, L, Calhoun, VD, Jung, RE, Caprihan, A (2015). Connectivity-based whole brain dual parcellation by group ICA reveals tract structures and decreased connectivity in schizophrenia. Human Brain Mapping.CrossRefGoogle Scholar
Yang, GJ, Murray, JD, Repovs, G, Cole, MW, Savic, A, Glasser, MF, Pittenger, C, Krystal, JH, Wang, XJ, Pearlson, GD, Glahn, DC, Anticevic, A (2014). Altered global brain signal in schizophrenia. Proceedings of the National Academy of Sciences USA 111, 7438–7443.CrossRefGoogle Scholar
Yu, C, Zhou, Y, Liu, Y, Jiang, T, Dong, H, Zhang, Y, Walter, M (2011). Functional segregation of the human cingulate cortex is confirmed by functional connectivity based neuroanatomical parcellation. NeuroImage 54, 2571–2581.CrossRefGoogle ScholarPubMed
Zald, DH, Kim, SW (1996). Anatomy and function of the orbital frontal cortex, II: function and relevance to obsessive-compulsive disorder. Journal of Neuropsychiatry and Clinical Neurosciences 8, 249–261.Google ScholarPubMed
Zanto, TP, Gazzaley, A (2013). Fronto-parietal network: flexible hub of cognitive control. Trends in Cognitive Sciences 17, 602–603.CrossRefGoogle ScholarPubMed

Xu supplementary material

Xu supplementary material

File 20 MB

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 24
Total number of PDF views: 165 *
View data table for this chart

* Views captured on Cambridge Core between 10th February 2017 - 5th March 2021. This data will be updated every 24 hours.

5 Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Selective functional disconnection of the orbitofrontal subregions in schizophrenia
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Selective functional disconnection of the orbitofrontal subregions in schizophrenia
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Selective functional disconnection of the orbitofrontal subregions in schizophrenia
Available formats
×
×

Reply to: Submit a response

Your details

Conflicting interests

Do you have any conflicting interests? *