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Sampling strategy in linkage studies of affective disorders

Published online by Cambridge University Press:  09 July 2009

M. Leboyer*
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
M. C. Babron
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
F. Clerget-Darpoux
INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Paris, France
1Address for correspondence: Dr M. Leboyer, INSERM U 155, Unité de Recherches d'Epidémiologie Génétique, Château de Longchamp, Bois de Boulogne, Paris 75016, France.


Evidence of linkage in families of bipolar patients has so far been identified with genetic markers on chromosome X and 11. However, replications of these data have not consistently been reported in either case, which favours the hypothesis of genetic heterogeneity. Therefore, we have tried to outline a sampling strategy for linkage replication in affective disorders. We estimated the average number of nuclear families required to replicate X or 11 linkage as a function of the degree of heterogeneity as well as the number to prove heterogeneity given that linkage exists. The results are presented and discussed.

Original Articles
Copyright © Cambridge University Press 1990

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