Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
  • Home
Hostname: page-component-559fc8cf4f-lzpzj Total loading time: 0.472 Render date: 2021-03-08T05:14:00.644Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }
EnglishFrançais
Psychological Medicine Psychological Medicine

Article contents

Insight in first-episode psychosis

Published online by Cambridge University Press:  02 June 2006

JOSEPH P. McEVOY ,
JACKIE JOHNSON ,
DIANA PERKINS ,
JEFFREY A. LIEBERMAN ,
ROBERT M. HAMER ,
RICHARD S. E. KEEFE ,
MAURICIO TOHEN ,
IRA D. GLICK  and
TONMOY SHARMA
JOSEPH P. McEVOY
Affiliation:
John Umstead Hospital, Duke University Department of Psychiatry, Butner, NC, USA
JACKIE JOHNSON
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA
DIANA PERKINS
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
JEFFREY A. LIEBERMAN
Affiliation:
Department of Psychiatry, Columbia University, New York, NY, USA
ROBERT M. HAMER
Affiliation:
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA
RICHARD S. E. KEEFE
Affiliation:
John Umstead Hospital, Duke University Department of Psychiatry, Butner, NC, USA
MAURICIO TOHEN
Affiliation:
Lilly Research Laboratories, Indianapolis, IN, USA
IRA D. GLICK
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, USA
TONMOY SHARMA
Affiliation:
Clinical Neuroscience Research Centre, Stonehouse Hospital, Dartford, Kent, UK
Get access
Rights & Permissions[Opens in a new window]

Abstract

Background. We report here a study examining the relationships between insight and psychopathology, cognitive performance, brain volume and co-morbid depression in 251 patients experiencing a first episode of psychosis, who were then randomly assigned to 2 years of double-blind treatment with either olanzapine or haloperidol.

Method. Repeated measures of insight were obtained at baseline and 12, 24, 52 and 104 weeks by the Insight and Treatment Attitudes Questionnaire (ITAQ).

Results. Older age, female gender and white ethnicity were associated with more insight. Higher total, positive, negative and general psychopathology scores on the Positive and Negative Syndromes Scale (PANSS) were associated with less insight. Higher depression scores were associated with more insight. Better neurocognitive function and large brain volumes were associated with more insight. More insight throughout the study was associated with longer time to medication non-adherence. However, baseline insight was not significantly related to the probability of discontinuing the study before 2 years. Insight improved significantly over the course of the study, but the improvement in insight was not significantly different between the two antipsychotic treatment groups.

Conclusions. Multiple factors contribute to insight. Patients experiencing a first episode of psychosis who have little insight are at increased risk of discontinuing their medication.

Type
Original Article
Information
Psychological Medicine , Volume 36 , Issue 10 , October 2006 , pp. 1385 - 1393
Copyright
2006 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below.
If you should have access and can't see this content please contact technical support.

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 0
Total number of PDF views: 121 *
View data table for this chart

* Views captured on Cambridge Core between September 2016 - 8th March 2021. This data will be updated every 24 hours.

83 Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Insight in first-episode psychosis
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Insight in first-episode psychosis
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Insight in first-episode psychosis
Available formats
×
×

Reply to: Submit a response

Your details

Conflicting interests

Do you have any conflicting interests? *