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Familial coaggregation of major psychiatric disorders among first-degree relatives of patients with obsessive-compulsive disorder: a nationwide study

Published online by Cambridge University Press:  07 January 2020

Mao-Hsuan Huang
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan
Chih-Ming Cheng
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan Department of Psychiatry, Taipei Veterans General Hospital, Yuanshan Branch, Taiwan
Shih-Jen Tsai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
Ya-Mei Bai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
Cheng-Ta Li
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
Wei-Chen Lin
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
Tung-Ping Su
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan
Tzeng-Ji Chen
Affiliation:
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan
Mu-Hong Chen
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan
Corresponding
E-mail address:

Abstract

Background

Whether the first-degree relatives (FDRs) of patients with obsessive-compulsive disorder (OCD) have an increased risk of the major psychiatric disorders, namely schizophrenia, bipolar disorder, OCD, major depressive disorder (MDD), autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD), remains unclear.

Methods

Using the Taiwan National Health Insurance Research Database with the whole population sample size (n = 23 258 175), 89 500 FDRs, including parents, offspring, siblings, and twins, of patients with OCD were identified in our study. The relative risks (RRs) of major psychiatric disorders were assessed among FDRs of patients with OCD.

Results

FDRs of patients with OCD had higher RRs of major psychiatric disorders, namely OCD (RR 8.11, 95% confidence interval (CI) 7.68–8.57), bipolar disorder (RR 2.85, 95% CI 2.68–3.04), MDD (RR 2.67, 95% CI 2.58–2.76), ASD (RR 2.38, 95% CI 2.10–2.71), ADHD (RR 2.19, 95% CI 2.07–2.32), and schizophrenia (RR 1.97, 95% CI 1.86–2.09), compared with the total population. Different familial kinships of FDRs, such as parents, offspring, siblings, and twins consistently had increased risks for these disorders. In addition, a dose-dependent relationship was found between the numbers of OCD probands and the risk of each major psychiatric disorder.

Conclusions

The FDRs, including parents, offspring, siblings, and twins, of patients with OCD have a higher risk of OCD, schizophrenia, bipolar disorder, MDD, ADHD, and ASD. The familial co-aggregation of OCD with OCD and other major psychiatric disorders was existent in a dose-dependent manner. Given the increased risks of psychiatric disorders, medical practitioners should closely monitor the mental health of the FDRs of patients with OCD.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2020

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Footnotes

*

Equally contributed.

Equally contributed.

References

Angst, J., Gamma, A., Endrass, J., Hantouche, E., Goodwin, R., Ajdacic, V., … Rossler, W. (2005). Obsessive-compulsive syndromes and disorders: Significance of comorbidity with bipolar and anxiety syndromes. European Archives of Psychiatry and Clinical Neuroscience, 255(1), 6571. doi: 10.1007/s00406-005-0576-8.CrossRefGoogle ScholarPubMed
Bienvenu, O. J., Samuels, J. F., Wuyek, L. A., Liang, K. Y., Wang, Y., Grados, M. A., … Nestadt, G. (2012). Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. Psychological Medicine, 42(1), 113. doi: 10.1017/S0033291711000742.CrossRefGoogle ScholarPubMed
Bolton, P. F., Pickles, A., Murphy, M., & Rutter, M. (1998). Autism, affective and other psychiatric disorders: Patterns of familial aggregation. Psychological Medicine, 28(2), 385395.CrossRefGoogle ScholarPubMed
Carter, A. S., Pollock, R. A., Suvak, M. K., & Pauls, D. L. (2004). Anxiety and major depression comorbidity in a family study of obsessive-compulsive disorder. Depression and Anxiety, 20(4), 165174. doi: 10.1002/da.20042.CrossRefGoogle Scholar
Cederlof, M., Lichtenstein, P., Larsson, H., Boman, M., Ruck, C., Landen, M., & Mataix-Cols, D. (2015). Obsessive-compulsive disorder, psychosis, and bipolarity: A longitudinal cohort and multigenerational family study. Schizophrenia Bulletin, 41(5), 10761083. doi: 10.1093/schbul/sbu169.CrossRefGoogle ScholarPubMed
Chen, M. H., Hsu, J. W., Huang, K. L., Bai, Y. M., Ko, N. Y., Su, T. P., … Chen, T. J. (2018). Sexually transmitted infection among adolescents and young adults with attention-deficit/hyperactivity disorder: A nationwide longitudinal study. Journal of the American Academy of Child and Adolescent Psychiatry, 57(1), 4853. doi: 10.1016/j.jaac.2017.09.438.CrossRefGoogle Scholar
Chen, M. H., Lan, W. H., Hsu, J. W., Huang, K. L., Su, T. P., Li, C. T., … Bai, Y. M. (2016). Risk of developing type 2 diabetes in adolescents and young adults with autism spectrum disorder: A nationwide longitudinal study. Diabetes Care, 39(5), 788793. doi: 10.2337/dc15-1807.CrossRefGoogle Scholar
Chen, M. H., Su, T. P., Chen, Y. S., Hsu, J. W., Huang, K. L., Chang, W. H., & Bai, Y. M. (2013). Attention deficit hyperactivity disorder, tic disorder, and allergy: Is there a link? A nationwide population-based study. Journal of Child Psychology and Psychiatry, 54(5), 545551. doi: 10.1111/jcpp.12018.CrossRefGoogle Scholar
Cheng, C. M., Chang, W. H., Chen, M. H., Tsai, C. F., Su, T. P., Li, C. T., … Bai, Y. M. (2018). Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: A nationwide population-based study. Molecular Psychiatry, 23(8), 17561763. doi: 10.1038/mp.2017.217.CrossRefGoogle ScholarPubMed
do Rosario-Campos, M. C., Leckman, J. F., Curi, M., Quatrano, S., Katsovitch, L., Miguel, E. C., & Pauls, D. L. (2005). A family study of early-onset obsessive-compulsive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 136B(1), 9297. doi: 10.1002/ajmg.b.30149.CrossRefGoogle ScholarPubMed
Eisen, J. L., Beer, D. A., Pato, M. T., Venditto, T. A., & Rasmussen, S. A. (1997). Obsessive-compulsive disorder in patients with schizophrenia or schizoaffective disorder. American Journal of Psychiatry, 154(2), 271273. doi: 10.1176/ajp.154.2.271.Google ScholarPubMed
Fyer, A. J., Lipsitz, J. D., Mannuzza, S., Aronowitz, B., & Chapman, T. F. (2005). A direct interview family study of obsessive-compulsive disorder. I. Psychological Medicine, 35(11), 16111621. doi: 10.1017/S0033291705005441.CrossRefGoogle ScholarPubMed
Geller, D., Petty, C., Vivas, F., Johnson, J., Pauls, D., & Biederman, J. (2007). Examining the relationship between obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in children and adolescents: A familial risk analysis. Biological Psychiatry, 61(3), 316321. doi: 10.1016/j.biopsych.2006.03.083.CrossRefGoogle ScholarPubMed
Goes, F. S., McCusker, M. G., Bienvenu, O. J., Mackinnon, D. F., Mondimore, F. M., Schweizer, B., … Potash, J. B. (2012). Co-morbid anxiety disorders in bipolar disorder and major depression: Familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder. Psychological Medicine, 42(7), 14491459. doi: 10.1017/S0033291711002637.CrossRefGoogle ScholarPubMed
Grados, M. A. (2010). The genetics of obsessive-compulsive disorder and Tourette syndrome: An epidemiological and pathway-based approach for gene discovery. Journal of the American Academy of Child and Adolescent Psychiatry, 49(8), 810819, 819 e811-812. doi: 10.1016/j.jaac.2010.04.009.CrossRefGoogle ScholarPubMed
Hanna, G. L., Himle, J. A., Curtis, G. C., & Gillespie, B. W. (2005). A family study of obsessive-compulsive disorder with pediatric probands. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 134B(1), 13-19. doi: 10.1002/ajmg.b.30138.CrossRefGoogle ScholarPubMed
Hanna, G. L., Veenstra-Vanderweele, J., Cox, N. J., Van Etten, M., Fischer, D. J., Himle, J. A., … Cook, E. H. Jr. (2007). Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder. Biological Psychiatry, 62(8), 856862. doi: 10.1016/j.biopsych.2007.01.008.CrossRefGoogle ScholarPubMed
Henin, A., Biederman, J., Mick, E., Sachs, G. S., Hirshfeld-Becker, D. R., Siegel, R. S., … Nierenberg, A. A. (2005). Psychopathology in the offspring of parents with bipolar disorder: A controlled study. Biological Psychiatry, 58(7), 554561. doi: 10.1016/j.biopsych.2005.06.010.CrossRefGoogle ScholarPubMed
Hettema, J. M. (2008). What is the genetic relationship between anxiety and depression? American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 148C(2), 140-146. doi: 10.1002/ajmg.c.30171.CrossRefGoogle ScholarPubMed
Hollander, E., King, A., Delaney, K., Smith, C. J., & Silverman, J. M. (2003). Obsessive-compulsive behaviors in parents of multiplex autism families. Psychiatry Research, 117(1), 1116.CrossRefGoogle ScholarPubMed
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. JAMA Psychiatry, 62(6), 593602. doi: 10.1001/archpsyc.62.6.593.Google ScholarPubMed
Kruger, S., Cooke, R. G., Hasey, G. M., Jorna, T., & Persad, E. (1995). Comorbidity of obsessive compulsive disorder in bipolar disorder. Journal of Affective Disorders, 34(2), 117120.CrossRefGoogle ScholarPubMed
Kuo, C. F., Grainge, M. J., Valdes, A. M., See, L. C., Luo, S. F., Yu, K. H., … Doherty, M. (2015). Familial aggregation of systemic lupus erythematosus and coaggregation of autoimmune diseases in affected families. JAMA Internal Medicine, 175(9), 15181526. doi: 10.1001/jamainternmed.2015.3528.CrossRefGoogle ScholarPubMed
Liu, C. Y., Hung, Y. T., Chuang, Y. L., Chen, Y. J., Weng, W. S., Liu, J. S., & Liang, K. Y. (2006). Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey. Journal of Health Management, 4(1), 122. doi: 10.29805/JHM.200606.0001.Google Scholar
Mataix-Cols, D., Boman, M., Monzani, B., Ruck, C., Serlachius, E., Langstrom, N., & Lichtenstein, P. (2013). Population-based, multigenerational family clustering study of obsessive-compulsive disorder. JAMA Psychiatry, 70(7), 709717. doi: 10.1001/jamapsychiatry.2013.3.CrossRefGoogle ScholarPubMed
Mathews, C. A., & Grados, M. A. (2011). Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: Heritability analysis in a large sib-pair sample. Journal of the American Academy of Child and Adolescent Psychiatry, 50(1), 4654. doi: 10.1016/j.jaac.2010.10.004.CrossRefGoogle Scholar
Meier, S. M., Petersen, L., Schendel, D. E., Mattheisen, M., Mortensen, P. B., & Mors, O. (2015). Obsessive-compulsive disorder and autism spectrum disorders: Longitudinal and offspring risk. PLoS ONE, 10(11), e0141703. doi: 10.1371/journal.pone.0141703.CrossRefGoogle ScholarPubMed
Monzani, B., Rijsdijk, F., Harris, J., & Mataix-Cols, D. (2014). The structure of genetic and environmental risk factors for dimensional representations of DSM-5 obsessive-compulsive spectrum disorders. JAMA Psychiatry, 71(2), 182189. doi: 10.1001/jamapsychiatry.2013.3524.CrossRefGoogle ScholarPubMed
Murphy, D. L., Moya, P. R., Fox, M. A., Rubenstein, L. M., Wendland, J. R., & Timpano, K. R. (2013). Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: Obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. Philosophical Transactions of the Royal Society B: Biological Sciences, 368(1615), 20120435. doi: 10.1098/rstb.2012.0435.CrossRefGoogle ScholarPubMed
Murray, C. J., & Lopez, A. D. (1996). The incremental effect of age-weighting on YLLs, YLDs, and DALYs: A response. Bulletin of the World Health Organization, 74(4), 445446.Google ScholarPubMed
Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O. J., 3rd, Liang, K. Y., LaBuda, M., … Hoehn-Saric, R. (2000). A family study of obsessive-compulsive disorder. JAMA Psychiatry, 57(4), 358363.Google ScholarPubMed
Nestadt, G., Samuels, J., Riddle, M. A., Liang, K. Y., Bienvenu, O. J., Hoehn-Saric, R., … Cullen, B. (2001). The relationship between obsessive-compulsive disorder and anxiety and affective disorders: Results from the Johns Hopkins OCD family study. Psychological Medicine, 31(3), 481487.CrossRefGoogle ScholarPubMed
O'Connell, K. S., McGregor, N. W., Lochner, C., Emsley, R., & Warnich, L. (2018). The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder. Molecular and Cellular Neuroscience, 88, 300307. doi: 10.1016/j.mcn.2018.02.010.CrossRefGoogle ScholarPubMed
Pauls, D. L., Abramovitch, A., Rauch, S. L., & Geller, D. A. (2014). Obsessive-compulsive disorder: An integrative genetic and neurobiological perspective. Nature Reviews Neuroscience, 15(6), 410424. doi: 10.1038/nrn3746.CrossRefGoogle ScholarPubMed
Plomin, R., Haworth, C. M., & Davis, O. S. (2009). Common disorders are quantitative traits. Nature Reviews Genetics, 10(12), 872878. doi: 10.1038/nrg2670.CrossRefGoogle ScholarPubMed
Ritter, M. L., Guo, W., Samuels, J. F., Wang, Y., Nestadt, P. S., Krasnow, J., … Shugart, Y. Y. (2017). Genome wide association study (GWAS) between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). Frontiers in Molecular Neuroscience, 10, 83. doi: 10.3389/fnmol.2017.00083.CrossRefGoogle Scholar
Shugart, Y. Y., Samuels, J., Willour, V. L., Grados, M. A., Greenberg, B. D., Knowles, J. A., … Nestadt, G. (2006). Genomewide linkage scan for obsessive-compulsive disorder: Evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Molecular Psychiatry, 11(8), 763770. doi: 10.1038/sj.mp.4001847.CrossRefGoogle ScholarPubMed
Taylor, S. (2011). Etiology of obsessions and compulsions: A meta-analysis and narrative review of twin studies. Clinical Psychology Review, 31(8), 13611372. doi: 10.1016/j.cpr.2011.09.008.CrossRefGoogle ScholarPubMed
Taylor, S. (2013). Molecular genetics of obsessive-compulsive disorder: A comprehensive meta-analysis of genetic association studies. Molecular Psychiatry, 18(7), 799805. doi: 10.1038/mp.2012.76.CrossRefGoogle ScholarPubMed
Tibbo, P., & Warneke, L. (1999). Obsessive-compulsive disorder in schizophrenia: Epidemiologic and biologic overlap. Journal of Psychiatry & Neuroscience, 24(1), 1524.Google ScholarPubMed
van Grootheest, D. S., Cath, D. C., Beekman, A. T., & Boomsma, D. I. (2005). Twin studies on obsessive-compulsive disorder: A review. Twin Research and Human Genetics, 8(5), 450458. doi: 10.1375/183242705774310060.CrossRefGoogle ScholarPubMed
Weissman, M. M., Bland, R. C., Canino, G. J., Greenwald, S., Hwu, H. G., Lee, C. K., … Wickramaratne, P. J. (1994). The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. Journal of Clinical Psychiatry, 55(Suppl), 510.Google ScholarPubMed
Wilcox, J. A., Tsuang, M. T., Schnurr, T., & Baida-Fragoso, N. (2003). Case-control family study of lesser variant traits in autism. Neuropsychobiology, 47(4), 171177. doi: 10.1159/000071210.CrossRefGoogle ScholarPubMed
Yelland, L. N., Salter, A. B., & Ryan, P. (2011). Performance of the modified Poisson regression approach for estimating relative risks from clustered prospective data. American Journal of Epidemiology, 174(8), 984992. doi: 10.1093/aje/kwr183.CrossRefGoogle ScholarPubMed
Zou, G. (2004). A modified Poisson regression approach to prospective studies with binary data. American Journal of Epidemiology, 159(7), 702706.CrossRefGoogle ScholarPubMed

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Familial coaggregation of major psychiatric disorders among first-degree relatives of patients with obsessive-compulsive disorder: a nationwide study
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