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Brain computerized tomography in subtypes of severe chronic schizophrenia

Published online by Cambridge University Press:  09 July 2009

Stephen M. Stahl*
Affiliation:
Schizophrenia Biological Research Center, Veterans Administration Medical Center, Palo Alto, Department of Psychiatry and Behavioural Sciences and the Department of Radiology, Stanford University Medical Center, Stanford, California, USA
Terry Jernigan
Affiliation:
Schizophrenia Biological Research Center, Veterans Administration Medical Center, Palo Alto, Department of Psychiatry and Behavioural Sciences and the Department of Radiology, Stanford University Medical Center, Stanford, California, USA
Adolf Pfefferbaum
Affiliation:
Schizophrenia Biological Research Center, Veterans Administration Medical Center, Palo Alto, Department of Psychiatry and Behavioural Sciences and the Department of Radiology, Stanford University Medical Center, Stanford, California, USA
Leslie Zatz
Affiliation:
Schizophrenia Biological Research Center, Veterans Administration Medical Center, Palo Alto, Department of Psychiatry and Behavioural Sciences and the Department of Radiology, Stanford University Medical Center, Stanford, California, USA
*
1Address for correspondence: Dr Stephen M. Stahl, Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR.

Synopsis

Computerized tomographic (CT) brain scans were obtained in severely ill, chronic schizophrenic patients hospitalized in a long-term in-patient facility of a Veterans Administration hospital, and compared to CT brain scans from an age, sex and education-matched normal control population. In contrast to results obtained in our previous studies with younger, less severely ill, chronic schizophrenic patients, the current study population exhibited significantly increased rankings of third ventricular size and of fronto-tempero-sylvian atrophy, compared to normal control subjects.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1988

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