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The association of affective disorder with Huntington's Disease in a case series and in families

Published online by Cambridge University Press:  09 July 2009

Susan E. Folstein ,
Margaret H. Abbott ,
Gary A. Chase ,
Barbara A. Jensen  and
Marshal F. Folstein
Susan E. Folstein*
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Margaret H. Abbott
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Gary A. Chase
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Barbara A. Jensen
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Marshal F. Folstein
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
*
1Address for correspondence: Dr Susan E. Foistein, Osler 320, The Johns Hopkins Hospital, Baltimore, MD 21205, USA.
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Synopsis

Major affective disorder clinically similar to the disorder found in conditions other than Huntington's Disease (HD) was found in 41% of patients with HD in a consecutive case series ascertained through multiple sources in a defined geographical area. The association appears to be confined to certain families, and affective disorder may appear as long as 20 years before the onset of chorea and dementia. The association may represent genetic heterogeneity in HD.

Type
Research Article
Information
Psychological Medicine , Volume 13 , Issue 3 , August 1983 , pp. 537 - 542
Copyright
Copyright © Cambridge University Press 1983

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