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5-Hydroxytryptamine metabolism in affective illness: the effect of tryptophan administration

  • G. W. Ashcroft (a1), T. B. B. Crawford (a1), R. L. Cundall (a1), D. L. Davidson (a1), Janet Dobson (a1), R. C. Dow (a1), D. Eccleston (a1), R. W. Loose (a1) and I. A. Pullar (a1)...

Synopsis

L-tryptophan 50 mg/kg was administered orally to patients suffering from either unipolar or bipolar affective illness, and the concentration of 5-hydroxyindol-acetic acid estimated in their cerebrospinal fluid eight hours later. There was no significant difference between the patient groups or between these and patients with neurological disease. These findings suggest a reduced neuronal activity in the 5-hydroxytryptaminergic system in some depressed patients rather than an absolute deficiency of tryptophan-5-hydroxylase. The synthesis of 5-HIAA in response to tryptophan varied with age.

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5-Hydroxytryptamine metabolism in affective illness: the effect of tryptophan administration

  • G. W. Ashcroft (a1), T. B. B. Crawford (a1), R. L. Cundall (a1), D. L. Davidson (a1), Janet Dobson (a1), R. C. Dow (a1), D. Eccleston (a1), R. W. Loose (a1) and I. A. Pullar (a1)...

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