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Racial differences and mydriatic response to tyramine

Published online by Cambridge University Press:  28 April 2020

P. Danjou
Affiliation:
Département de Pharmacologie Clinique, Hôpital de la Salpêtrière, 47-83 Bd de l'Hôpital, 75651 , Paris, cédex 13, France
D. Warot
Affiliation:
Département de Pharmacologie Clinique, Hôpital de la Salpêtrière, 47-83 Bd de l'Hôpital, 75651 , Paris, cédex 13, France
A.J. Puech
Affiliation:
Département de Pharmacologie Clinique, Hôpital de la Salpêtrière, 47-83 Bd de l'Hôpital, 75651 , Paris, cédex 13, France
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Summary

In a preliminary study the effect of tyramine, used as eye-drops, was assessed in two different ethnical groups composed of healthy volunteers: 6 Africans and 6 Caucasians.

Tyramine-induced mydriasis in the Caucasian group was 5 times greater than in the African group.

Similar differences had already been observed for indirect sympathominetic amines (ephedrine and cocaine) used as mydriatics, as well as for the effects of alpha 1 blocking drugs on the vascular system.

Very few data are available in the literature concerning the CNS effects of drugs modulating the alpha adrenergic receptors.

Résumé

Résumé

Dans une étude préliminaire l'effet mydriatique de la tyramine administrée sous forme de collyre a été étudié chez deux groupes de volontaires sains composés respectivement de 6 Africains et de 6 Caucasiens.

Dans le groupe caucasien, la tyramine a entraîné une mydriase 5 fois plus importante que dans le groupe africain.

Des différences identiques avaient été mises en évidence pour des collyres sympathomimétiques indirects (éphédrine, cocaïne) ainsi que pour des substances alpha I bloquantes dont l'effet avait été étudié sur le système vasculaire.

Des variations interethniques des métabolismes enzymatiques ou des différences de sensibilité des récepteurs alpha l adrénergiques pourraient expliquer les différences observées.

Très peu de données sont disponibles dans la littérature concernant les effets sur le système nerveux central des substances interagissant avec les récepteurs alpha-adrénergiques.

Type
Research Article
Copyright
Copyright © European Psychiatric Association 1987

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References

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