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Heat capacity change for ribonuclease A folding

  • C. NICK PACE (a1) (a2) (a3), GERALD R. GRIMSLEY (a1), SUSAN T. THOMAS (a4) and GEORGE I. MAKHATADZE (a4)

Abstract

The change in heat capacity ΔCp for the folding of ribonuclease A was determined using differential scanning calorimetry and thermal denaturation curves. The methods gave equivalent results, ΔCp = 1.15 ± 0.08 kcal mol−1 K−1. Estimates of the conformational stability of ribonuclease A based on these results from thermal unfolding are in good agreement with estimates from urea unfolding analyzed using the linear extrapolation method.

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Corresponding author

Reprint requests to: Dr. C.N. Pace, Medical Biochemistry, Texas A&M University, College Station, Texas 77843-1114; e-mail: nickpace@tamu.edu.

Keywords

Heat capacity change for ribonuclease A folding

  • C. NICK PACE (a1) (a2) (a3), GERALD R. GRIMSLEY (a1), SUSAN T. THOMAS (a4) and GEORGE I. MAKHATADZE (a4)

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