Skip to main content Accessibility help

Comparative Neuropsychological Effects of Lamotrigine and Topiramate in Healthy Volunteers

  • Kimford J. Meador (a1)


Corresponding author

Correspondence should be addressed to: Kimford J. Meador MD, Department of Neurology, McKnight Brain Institute (L3-100), University of Florida, 100 South Newell Drive, Gainesville, FL 32611, USA; Ph: +1 352 273 5550; Fax: +1 352 273 5575; Email:


Hide All


Abbetz, L., Jacoby, A., Baker, G.A., & McNulty, P. (2000). Patient based assessments of quality of life in newly diagnosed epilepsy patients: validation of the NEWQOL. Epilepsia, 41, 11191128.
Aldenkamp, A.P., Baker, G., Pieters, M.S., Schoemaker, H.C., Cohen, A.F., & Schwabe, S. (1995). The neurotoxicity scale: the validity of a patient-based scale assessing neurotoxicity. Epilepsy Research, 20, 229239.
Aldenkamp, A.P., Baker, G., Mulder, O.G., et al. (2000). A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures. Epilepsia, 41, 11671178.
Aldenkamp, A.P., Arends, J., Bootsma, H.P., et al. (2002). Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers. Epilepsia, 43, 1926.
Brodie, M.J., Richens, A., & Yuen, A.W.C. (1995). Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet, 345, 476479.
Brodie, M.J., Overstall, P.W., Giorgi, L., & UK Lamotrigine Elderly Study Group (1999). Multicentre, double-blind, randomized comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. Epilepsy Researh, 37, 8187.
Burton, L.A., & Harden, C. (1997). Effect of topiramate on attention. Epilepsy Research, 27, 2932.
Buschke, H., & Fuld, P.A. (1974). Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology, 24, 10191025.
Cohen, A.F., Ashby, L., Crowley, D., Land, G., Peck, A.W., & Miller, A.A. (1985). Lamotrigine (BW430C) potential anticonvulsant. Effects on the central nervous in comparison with phenytoin and diazepam. British Journal of Clinical Pharmacology, 29, 619629.
Devinsky, O., Vickrey, B.G., Cramer, J., et al. (1995). Development of the quality of life in epilepsy (QOLIE) Inventory. Epilepsia, 36, 10891104.
Dodrill, C.B., Arnett, J.L., Sommerville, K.W., & Sussman, N.M. (1995). Effects of differing dosages of vigabatrin (Sabril) on cognitive abilities and quality of life in epilepsy. Epilepsia, 36, 164173.
Dunn, L.M., & Dunn, L.M. (1997). Peabody Picture Vocabulary Test (3rd ed.). Circle Pines, MN: American Guidance Services.
Follett, P.L., Deng, W., Dai, W., Talos, D.M., Massillon, L.J., Rosenberg, P.A., Volpe, J.J., & Jensen, F.E. (2004). Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. Neurosci, 24, 44124420.
Fritz, N., Glogau, S., Hoffmann, J., Rademacher, M., Elger, C.E., & Helmstaedter, C. (2005). Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy and Behavior, 6, 373381.
Gillham, R., Baker, G., Thompson, P., et al. (1996). Standardization of self-report questionnaire for use in evaluating cognitive, affective and behavioral side-effects of antiepileptic drug treatments. Epilepsy Research, 24, 4755.
Gilliam, F. (2003). The impact of epilepsy on subjective health status. Current Neurology and Neuroscience Reports, 3, 357362.
Glauser, T.A. (1999). Topiramate. Epilepsia, 40, S71S80.
Glier, C., Dzietko, M., Bittigau, P., et al. (2004). Therapeutic doses of topiramate are not toxic to the developing rat brain. Experimental Neurology, 187, 403409.
Golden, C.J. (1978). Stroop Color and Word Test. A Manual for Clinical and Experimental Uses. Chicago: Stoelting.
Hamilton, M.J., Cohen, A.F., Yuen, A.W.C., et al. (1993). Carbamazepine and lamotrigine in healthy volunteers: relevance to early tolerance and clinical trial dosages. Epilepsia, 34, 166173.
Henry, J.D., & Crawford, J.R. (2004). A meta-analytic review of verbal fluency performance following cortical lesions. Neuropsychology, 18, 284295.
Jette, N.J., Marson, A.G., & Hutton, J.L. (2002). Topiramate add-on for drug-resistant partial epilepsy. Cochrane Database Systematic Reviews, 3, CD001417.
Kaplan, E., Goodglass, H. & Weintraub, S. (1983). The Boston Naming Test. Philadelphia: Lea & Febiger.
Lachman, R., Lachman, J.L., & Butterfield, E.C. (1979). Cognitive Psychology and Information Processing: An Introduction. Hillsdale, NJ: Lawrence Erlbaum.
LaRoche, S.M., & Helmers, S.L. (2004). The new antiepileptic drugs: scientific review. Journal of the American Medical Association, 291, 605614.
Lee, Y.J., Ellenberg, J.H., Hirtz, D.G., & Nelson, K.B. (1991). Analysis of clinical trials by treatment actually received: is it really an option? Statistics in Medicine, 10, 15951605.
Lee, S., Sziklas, V., Andermann, F., et al. (2003a). The effects of adjunctive topiramate on cognitive function in patients with epilepsy. Epilepsia, 44, 339347.
Lee, S., Sziklas, V., Andermann, F., et al. (2003b). The effects of adjunctive topiramate on cognitive function in patients with epilepsy. Epilepsia, 44, 339347.
Lezak, M.D. (1995). Neuropsychological Assessment (3rd ed.). New York: Oxford University Press.
Loring, D.W., & Meador, K.J. (2004). Cognitive side effects of antiepileptic drugs in children. [Review]. Neurology, 62, 872877.
Lorr, M., McNair, D.M., & Droppleman, L.F. (1971). Manual: Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service.
Martin, R., Kuzniecky, R., Ho, S., et al. (1999). Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology, 52, 321327.
Meador, K.J. (1998). Cognitive and behavioral assessments in AED trials. Antiepileptic Drug Development. Advances in Neurology, 23, 231237.
Meador, K.J. (2004a). Cognitive effects of epilepsy and of antiepileptic medications. In: Wyllie, E. (ed.), The Treatment of Epilepsy: Principles and Practice (4th ed.). Philadelphia: Lippincott Williams & Wilkins, pp. 12151226.
Meador, K.J. (2004b). Cognitive deficits from in utero AED exposure. Epilepsy Currents, 4, 196197.
Meador, K.J., Loring, D.W., Allen, M.E., et al. (1991). Comparative cognitive effects of carbamazepine and phenytoin in healthy adults. Neurology, 41, 15371540.
Meador, K.J., Loring, D.W., Abney, O.L., et al. (1993). Effects of carbamazepine and phenytoin on EEG and memory in healthy adults. Epilepsia, 34, 153115.
Meador, K.J., Loring, D.W., Moore, E.E., et al. (1995). Comparative cognitive effects of phenobarbital, phenytoin and valproate in healthy subjects. Neurology, 45, 14941499.
Meador, K.J., Loring, D.W., Ray, P.G., et al. (1999). Differential cognitive effects of carbamazepine and gabapentin. Epilepsia, 40, 12791285.
Meador, K.J., Loring, D.W., Ray, P.G., et al. (2001). Differential cognitive and behavioral effects of carbamazepine and lamotrigine. Neurology, 8, 11771182.
Meador, K.J., Loring, D.W., Hulihan, J.F., Kamin, M., & Karim, R. (2003). Differential cognitive and behavioral effects of topiramate and valproate. Neurology, 60, 14831488.
Meador, K.J., Loring, D.W., Vahle, V.J., Ray, P.G., Werz, M.A., Fessler, A.J., Ogrocki, P. Schoenberg, M.R., Miller, J.M., & Kustra, R.P. (2005). Cognitive and behavioral effects of lamotrigine and topiramate in healthy volunteers. Neurology, 64, 21082115.
Perrine, K., Hermann, B.P., Meador, K.J., Vickrey, B.G., Cramer, J.A., Hays, R.D., & Devinsky, O. (1995). The relationship of neuropsychological functioning to quality of life in epilepsy. Archives of Neurology, 52, 9971003.
Physicians' Desk Reference. (2005) (60th ed.). Montvale, NJ: Thomson PDR.
Ray, P.G., Meador, K.J., Loring, D.W., Zamrini, E.Y., Yang, X.H., & Buccafusco, J.J. (1992). Central anticholinergic hypersensitivity in aging. Journal of Geriatric Psychiatry and Neurology, 5, 7277.
Rowan, A.J., Ramsay, R.E., Collins, J.F., Pryor, F., Boardman, K.D., Uthman, B.M., Spitz, M., Frederick, T., Towne, A., Carter, G.S., Marks, W., Felicetta, J., Tomyanovich, M.L., & VA Cooperative Study 428 Group. (2005). New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology, 64, 18681873.
Salinsky, M.C., Storzbach, D., Spencer, D.C., Oken, B.S., Landry, T., & Dodrill, C.B. (2005). Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers. Neurology, 64, 792798.
Smith, A. (1973). Symbol Digit Modalities Test. Manual. Los Angeles: Western Psychological Services.
Smith, D., Baker, G., Davies, G., Dewey, M., & Chadwick, D.W. (1993). Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia, 34, 312322.
Spreen, O., & Strauss, E. (1998). A Compendium of Neuropsychological Tests: Administration, Norms and Commentary. New York: Oxford University Press.
Steiner, T.J., Dellaportas, C.I., Findley, L.J., et al. (1999). Lamotrigine monotherapy in newly diagnosed untreated epilepsy: a double-blind comparison with phenytoin. Epilepsia, 40, 601607.
Thompson, P.J., Baxendale, S.A., & Duncan, J.S., Sander, J.W.A.S. (2000). Effects of topiramate on cognitive function. Journal of Neurology Neurosurgery and Psychiatry, 69, 636641.
Ware, J.E., Kosinski, M., & Keller, S.D. (1996). A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Medical Care, 34, 220233.
Zhao, Q., Hu, Y., & Holmes, G.L. (2005). Effect of topiramate on cognitive function and activity level following neonatal seizures. Epilepsy Behavior, 6, 529536.


Related content

Powered by UNSILO

Comparative Neuropsychological Effects of Lamotrigine and Topiramate in Healthy Volunteers

  • Kimford J. Meador (a1)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.