Skip to main content Accessibility help
×
Home

Monoclonal anti lymphocyte antibodies as immunosuppressive reagents for clinical practice

  • John W. Fabre (a1)

Synopsis

By the late 1970s it had become clear that the immunosuppressive effects of conventional anti lymphocyte serum (ALS) were mediated by only a small component of the anti lymphocyte antibodies present. This fact meant that attempts to improve the safety, potency and standardisation of conventional ALS by raising xenosera to single, purified lymphocyte antigens were faced with considerable technical and theoretical problems. Coincidentally and very fortunately, it was at this time that the potential of monoclonal antibodies in the field of ALS were becoming obvious. Their advent has dramatically transformed the situation, from a bleak one with few prospects to one where the early promise of ALS is likely to be realised in the clinic within the next few years. This review looks at why it is that monoclonal antibodies have so changed the situation, and then discusses in detail the optimal properties, in terms of specificity and other characteristics, of immunosuppressive monoclonal antibodies, and finally looks at precisely how they should be used in the clinic.

Copyright

References

Hide All
Beverley, P. 1982. The application of monoclonal antibodies to the typing and isolation of lymphoreticular cells. Proc. Roy. Soc. Edinb. 81B, 000-000.
Bieber, C. P., Howard, F. D. Pennock, J., Wong, J., Shorthouse, R. and Stinson, E. B. 1981. Preparation, characterisation and primate testing of monoclonal anti thymocyte globulin Transplantation 31, 283289.
Brent, L., Horsburgh, H., Rowland, G. and Wood, P. 1980. Failure to increase the in vivo immunosuppressive activity of antilymphocyte globulin by conjugation with malphalan. Transplantation 29, 280282.
Cosimi, A. B., Burton, R. C., Kung, P. C., Colvin, R., Goldstein, G., Lifter, J., Rhodes, W. and Russell, P. S. 1981a. Evaluation in primate renal allograft recipients of monoclonal antibody to human T cell subclasses. Transplant. Proc. 13, 499503.
Cosimi, A. B., Colvin, R. B., Burton, R. C., Rubin, R. H., Goldstein, G., Kung, P. C., Hansen, W. P., Delmonico, F. L. and Russell, P. S. 1981b. Use of monoclonal antibodies to T cell subsets for immunological monitoring and treatment in recipients of renal allografts. New Engl. J. Med. 3055, 308314.
Dalchau, R. and Fabre, J. W. 1980. Quantitative studies of the tissue distribution of the antigens recognised by rabbit anti rat, dog and human lymphocyte sera. Clin. Exp. Immun. 41, 182187.
Dresser, D. W. 1962. Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology 5, 378388.
Editorial, 1975. Current status of antilymphocyte globulin. Br. Med. J. 1, 644645.
Edwards, D. C., Smith, A., Ross, W. C. J., Cumber, A. J., Thorpe, E. P. and Davies, A. J. S. 1981. The effect of abrin, anti-lymphocyte globulin and their conjugates on the immune response of mice to sheep red blood cells. Experientia 37, 256257.
Fabre, J. W. and Williams, A. F. 1977. Quantitative serological analysis of a rabbit anti rat lymphocyte serum and preliminary biochemical characterisation of the major antigen recognised. Transplantation 23, 349359.
Fabre, J. W., Sunderland, C. A. and Williams, A. F. 1980. Immunosuppressive properties of rabbit antibodies against a major glycoprotein restricted to rat leucocyte membranes. Transplantation 30, 167173.
Howard, F. D., Ledbetter, J. A., Wong, J., Bieber, C. P., Stinson, E. B. and Herzenberg, L. A. 1979. A human T lymphocyte differentiation marker defined by monoclonal antibodies that block E-rosette formation. J. Immun. 126, 21172122.
Howard, J. C., Butcher, G. W., Galfre, G., Milstein, C. and Milstein, C. P. 1979. Monoclonal antibodies as tools to analyse the serological and genetic complexities of major transplantation antigens. Immun. Rev. 47, 139174.
Kohler, G. and Milstein, C. 1975. Continuous cultures of hybrid cells secreting antibody of predefined specificity. Nature, Lond. 256, 495497.
Olsson, L. and Kaplan, H. S. 1980. Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity. Proc. Nam Acad. Sci. U.S.A. 77, 54295431.
Reinherz, E. L., Kung, P. C., Goldstein, G. and Schlossman, S. F. 1979a. Further characterisation of the human inducer T cell subset defined by monoclonal antibody. J. Immun. 123, 28942896.
Reinherz, E. L., Kung, P. C., Goldstein, G. and Schlossman, S. F. 1979b. A monoclonal antibody with selective reactivity with functionally nature human thymocytes and all peripheral human T cells. J. Immun. 126, 13121317.
Reinherz, E. L., Hussey, R. E. and Schlossman, S. F. 1980. A monoclonal antibody blocking human T cell function. Eur. J. Immun. 10, 758762.
Reinherz, E. L. and Schlossman, S. F. 1981. The characterisation and function of human immunoregulatory T lymphocyte subsets. Immun. Today 2, 6975.
Sunderland, C. A., McMaster, W. R. and Williams, A. F. 1979. Purification with monoclonal antibody of a predominant leucocyte common antigen and glycoprotein from rat thymocytes. Eur. J. Immun. 9, 155159.
Thorpe, P. E., Cumber, A. J., Williams, N., Edwards, D. C. and Ross, W. C. J. 1981. Abrogation of the nonspecific toxicity of abrinconjugated to anti lymphocyte globulin. Clin. Exp. Immun. 43, 195200.
Thorpe, P. E., Edwards, D. C., Davies, A. J. S. and Ross, W. C. J. 1982. Monoclonal antibody–toxin conjugates: aiming the magic bullet. In Monoclonal Antibodies in Clinical Medicine, ed. McMichael, A. J. and Fabre, J. W. London: Academic Press
van Wauwe, J. P., de Mey, J. R. and Goossens, J. G. 1980. OKT3: a monoclonal anti human T lymphocyte antibody with potent mitogenic properties. J. Immun. 124, 27082713.
Woodruff, M. F. A. and Anderson, N. A. 1963. Effect of lymphocyte depletion by thoracic duct fistula and administration of anti lymphocyte serum on the survival of skin homografts in rats. Nature, Lond. 200, 702.

Monoclonal anti lymphocyte antibodies as immunosuppressive reagents for clinical practice

  • John W. Fabre (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.