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Probiotics and the immune response to vaccines

  • Thomas T. MacDonald (a1) and Iona Bell (a1)

Abstract

Probiotics are bacteria, but sometimes fungi, which when taken by the oral route may give some health benefits. The most compelling evidence for beneficial effects of probiotics is in the prevention and reduction in the duration of symptoms related to gut infectious disease. There is also evidence to show that some specific probiotics are beneficial in Clostridium difficile diarrhoea in the elderly. As further and better controlled clinical studies have appeared, some specific probiotics also appear to have beneficial effects in perhaps preventing and reducing the duration of symptoms due to acquired upper respiratory tract infections. In an attempt to explain these effects, attention has turned to the effects of some specific probiotics on the immune system. There is evidence that some specific probiotics can alter monocyte and natural killer cell function in the blood. Evidence is also accumulating that taking some specific probiotics can boost antibody responses to oral and systemically administered vaccines. The effect when shown is modest and is not always seen in different studies to all vaccines, but there is enough of a trend to make the area worthy of further investigation, particularly to tease out the mechanisms involved.

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Corresponding author

*Corresponding author: Thomas T. MacDonald, fax +44 207 8822185, email t.t.macdonald@qmul.ac.uk

References

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1.Solis, B, Samartin, S, Gómez, S et al. (2002) Probiotics as a help in children suffering from malnutrition and diarrhoea. Eur J Clin Nutr 56, Suppl. 3, S57S59.
2.Hatakka, K & Saxelin, M (2008) Probiotics in intestinal and non-intestinal infectious diseases – clinical evidence. Curr Pharm Des 14, 13511367.
3.Guandalini, S (2008) Probiotics for children with diarrhea: an update. J Clin Gastroenterol 42, Suppl. 2, S53S57.
4.Parkes, GC, Sanderson, JD & Whelan, K (2009) The mechanisms and efficacy of probiotics in the prevention of clostridium difficile-associated diarrhoea. Lancet Infect Dis 9, 237244.
5.Prantera, C & Scribano, ML (2009) Antibiotics and probiotics in inflammatory bowel disease: why, when, and how. Curr Opin Gastroenterol 25, 329333.
6.Hickson, M, D'Souza, AL, Muthu, N et al. (2007) Use of probiotic lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial. BMJ 335, 80; Epublication 29 June 2007.
7.Vouloumanou, EK, Makris, GC, Karageorgopoulos, DE et al. (2009) Probiotics for the prevention of respiratory tract infections: a systematic review. Int J Antimicrob Agents 34, 197.E1–10.
8.Turchet, P, Laurenzano, M, Auboiron, S et al. (2003) Effects of fermented milk containing the probiotic Lactobacillus casei DN-114 001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study. J Nutr Health Aging 7, 7577.
9.De Vrese, M, Winkler, P, Rautenberg, P et al. (2006) Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. Vaccine 24, 66706674.
10.Layer, JG, Li, S, Mubasher, EM et al. (2009) Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics 124, E172E179.
11.Guillemard, E, Tondu, F, Lacoin, F et al. (2009) Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr 103, 5868.
12.Schiffrin, EJ, Rochat, F, Link-Amster, H et al. (1995) Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci 78, 491497.
13.Gill, HS, Rutherfurd, KJ, Cross, ML et al. (2001) Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr 74, 833839.
14.Parra, D, Martinez de Morentin, B, Cobo, JM et al. (2004) Monocyte function in healthy middle-aged people receiving fermented milk containing Lactobacillus casei. J Nutr Health Aging 8, 208211.
15.Nagao, F, Nakayama, M, Muto, T et al. (2000) Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects. Biosci Biotechnol Biochem 64, 27062708.
16.Morimoto, K, Takeshita, T, Nanno, M et al. (2005) Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in habitual smokers. Prev Med 40, 589594.
17.Marschan, E, Kuitunen, M, Kukkonen, K et al. (2008) Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation. Clin Exp Allergy 38, 611618.
18.Isolauri, E, Joensuu, J, Suomalainen, H et al. (1995) Improved immunogenicity of oral D x RRV reassortant rotavirus vaccine by Lactobacillus casei GG. Vaccine 13, 310312.
19.De Vrese, M, Rautenberg, P, Laue, C et al. (2005) Probiotic bacteria stimulate virus-specific neutralizing antibodies following a booster polio vaccination. Eur J Nutr 44, 406413.
20.Kukkonen, K, Nieminen, T, Poussa, T et al. (2006) Effect of probiotics on vaccine antibody responses in infancy – a randomized placebo-controlled double-blind trial. Pediatr Allergy Immunol 17, 416421.
21.West, CE, Gothefors, L, Granström, M et al. (2008) Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines. Pediatr Allergy Immunol 19, 5360.
22.Nauta, JJ, Beyer, WE & Osterhaus, AD (2009) On the relationship between mean antibody level, seroprotection and clinical protection from influenza. Biologicals 37, 216221.
23.Boge, T, Rémigy, M, Vaudaine, S et al. (2009) A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine 27, 56775684.
24.Mortensen, RF (2001) C-reactive protein, inflammation, and innate immunity. Immunol Res 24, 163176.
25.Akira, S, Hirano, T, Taga, T et al. (1990) Biology of multifunctional cytokines:IL 6 and related molecules (IL1 and TNF). FASEB J 4, 28602867.
26.Karlsson, H, Larsson, P, Wold, AE et al. (2004) Pattern of cytokine responses to gram-positive and gram-negative commensal bacteria is profoundly changed when monocytes differentiate into dendritic cells. Infect Immun 72, 26712678.
27.Mohamadzadeh, M, Olson, S, Kalina, WV et al. (2005) Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc Natl Acad Sci USA 102, 28802885.
28.Hart, AL, Lammers, K, Brigidi, P et al. (2004) Modulation of human dendritric cell phenotype and function by probiotic bacteria. Gut 53, 16021609.
29.Van Baarlen, P, Troost, FJ, Van Hemert, S et al. (2009) Differential NF-kappaB pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance. Proc Natl Acad Sci USA 106, 23712376.
30.MacDonald, TT (2008) The gut is still the biggest lymphoid organ in the body. Mucosal Immunol 1, 246247.
31.Jameson, B, Baribaud, F, Pöhlmann, S et al. (2002) Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in human and rhesus macaques. J Virol 76, 18661875.
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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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