Skip to main content Accessibility help
×
Home

Contents:

Information:

  • Access

Actions:

      • Send article to Kindle

        To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

        Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

        Find out more about the Kindle Personal Document Service.

        Evidence of a detrimental effect of low vitamin D status on markers of cardiovascular health in the Vitamin D, Food Intake, Nutrition and Exposure to Sunlight in southern England (D-FINES) Study population: ethnic and age influences
        Available formats
        ×

        Send article to Dropbox

        To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

        Evidence of a detrimental effect of low vitamin D status on markers of cardiovascular health in the Vitamin D, Food Intake, Nutrition and Exposure to Sunlight in southern England (D-FINES) Study population: ethnic and age influences
        Available formats
        ×

        Send article to Google Drive

        To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

        Evidence of a detrimental effect of low vitamin D status on markers of cardiovascular health in the Vitamin D, Food Intake, Nutrition and Exposure to Sunlight in southern England (D-FINES) Study population: ethnic and age influences
        Available formats
        ×
Export citation

There are clear associations between vitamin D deficiency and insulin resistance, β-cell dysfunction and reduced insulin secretion. There are also data linking vitamin D ‘insufficiency’ as a risk factor for metabolic syndrome, hypertension and diabetes, all of which may clarify its association with increased CVD. These associations are particularly apparent in Asian groups and may underlie the considerable predisposition to CVD in this group. Poor vitamin D status may hence be associated with raised total cholesterol and inversely related to the serum concentration of cardio-protective HDL, although limited data on UK populations are available.

The D-FINES Study is currently investigating the interaction between diet and sunlight exposure on vitamin D status in Caucasian and Asian women aged 19–70 (mean 48.0 (sd 14.3)) years living in southern England. Fasted blood samples were collected at three-monthly intervals from summer 2006 to spring 2007 from a total of 279 Caucasian and ninety-four Asian women and dietary intake was assessed during these periods using 4 d estimated food records. Women were recruited through general practice or through Asian community networks in Woking, Kingston and Thornton Health. The aim of the present subsidiary study was to examine the relationship between summer vitamin D status and serum lipid profiles (serum TAG and HDL) and insulin.

Table. Descriptive data and spearman correlation (r values) between markers of cardiovascular health and serum 25-hydroxyvitamin D (25-OHD) in Caucasian and Asian women from the D-FINES Study

***P<0.001. a,bMeans with unlike superscript letters were significantly different (Mann-Witney U test; P=0.016–0.001).

As shown in the Table, the mean serum 25-OHD level was significantly lower in Asian women compared with Caucasian women (P<0.0001). The mean BMI was 26.0 (sd 4.77) kg/m2 for Caucasian women and 27.8 (sd 5.70) kg/m2 for Asian women. There was a higher TAG in Asian women compared with Caucasian women (P<0.001) and higher HDL in Caucasian women than in Asian women (P<0.002). Insulin levels were significantly higher in the Asian women (P<0.001). Significant negative correlations were found between markers of cardiovascular health and 25OHD status in all groups combined and then specifically in the Caucasian women but not in the Asian women. Blunting of 25OHD levels, i.e. severe vitamin D deficiency, has been previously noted in Asian women with having a 25OHD level of <25 nmol/l (depending on seasons)(1) and may explain the lack of association between 25OHD and markers of cardiovascular health. The present findings are a cause for concern and warrant further investigation.

The D-FINES Study is funded by the Food Standards Agency (Project no. NO5064). O. A. H. is grateful to the Royal Embassy of Saudi Arabia for PhD funding.

1. Darling, AL, Lovell, D, Lee, PA et al. . (2010) Proc Nutr Soc 69, OCE1, E125.