Galaxy interactions play an important role in the evolution of galaxies and triggering galaxy-wide star-formation or accretion onto nuclear black-holes. However, the strength and details of the relationship between galaxy interactions and triggered activity are still unclear. In order to address these questions we embarked on a Spitzer multi-wavelength study of a sample of nearby interacting galaxy systems. Our goal is to investigate: how interactions trigger star-formation by studying the spatial distribution and level of star-formation, and comparing them with theoretical models for different interaction parameters; how the interactions drive gas in the nuclear regions, and how this gas promotes and/or hides nuclear activity, by studying the distribution of dust and performing deep spectroscopic observations of the galactic nuclei; and how star-formation and AGN activity depend on the interaction stage.