Multi-wavelength analyses of an increasing number of post-AGB stars reveal that they constitute a more inhomogeneous population of stars than previously thought. The new data collected in the last few years allow us to study these sources with unprecedented spatial resolution and to extend our spectroscopic knowledge in a systematic way to the infrared for the first time, where crucial information is contained on the chemical composition of the gas and dust in their circumstellar shells. The overall infrared properties derived from ISO and Spitzer data can be used to trace the mass loss history and the chemical evolution of the ejected material. The new results impose severe observational constraints on current nucleosynthesis models and suggest that the evolution is determined not only by the initial mass but also by the metallicity of the progenitor star. Post-AGB samples are likely to grow in the near future with the advent of new data from space facilities like Spitzer or Akari. Studies of post-AGB stars in the galactic halo, the Magellanic Clouds and other galaxies of the Local Group will certainly improve our knowledge on the evolutionary connections between AGB stars and PNe.