Very metal-poor (VMP) stars preserve chemical signatures of early generations of stars, and are crutial to understand the early nucleosynthesis and first stars. Millions of stellar spectra obtained by LAMOST provide an unprecedented chance to enlarge the currently limited VMP star sample. Since 2014, a joint project on searching for VMP stars has been conducted based on the LAMOST survey and Subaru follow-up observations. So far, the project has obtained chemical abundances for about 250 VMP stars and a number of chemically interesting objects, e.g., three ultra metal-poor stars with [Fe/H] ~ − 4.0, a dozen Li-rich VMP stars distributed in a wide range of evolutionary stages. Statistics of the large homogeneous sample of VMP stars will be of great interest and importance to probe the chemical enrichment in the early Galaxy and low-mass star evolution.