We present predictions for the spatial distribution of 21 cm brightness temperature fluctuations from high-dynamic-range simulations for AGN-dominated reionization histories that have been tested against available Lyα and CMB data. We model AGN by extrapolating the observed Mbh–σ relation to high redshifts and assign them ionizing emissivities consistent with recent UV luminosity function measurements. AGN-dominated reionization histories increase the variance of the 21 cm emission by a factor of up to ten compared to similar reionization histories dominated by faint galaxies, to values close to 100 mK2 at scales accessible to experiments (k ≲ 1 cMpc−1h). This is lower than the sensitivity reached by ongoing experiments by only a factor of about two or less. AGN dominated reionization should be easily detectable by LOFAR (and later HERA and SKA1) at their design sensitivity.