Star formation, from cold giant molecular clouds to diverse population of stars, is a complex process involving a wide variety of physical processes. In this work, we constrain the link between the gas-star formation cycle and several secular and environmental probe of galaxies. Specifically, we quantify the spatial correlation between molecular gas and star-forming regions for 49 nearby galaxies using the ALMA and narrowband-Hα imaging from the PHANGS survey. At the resolution (150 pc) at which the individual molecular clouds and star-forming regions can be identified, we find that molecular clouds and star-forming regions do not necessarily coexist. The decoupled molecular clouds and star-forming regions are a signature of evolutionary cycling and feedback of the star formation process. Therefore, the impact of galactic-scale conditions and environments must be considered for a complete understanding of how stars form in galaxies and how this process influences the evolution of the host galaxies.