Skip to main content Accessibility help
×
Home

Predicting inbreeding using markers and long-term genetic contributions

  • J. Hernandez-Sanchez (a1), C. S. Haley (a1) and J. A. Woolliams (a1)

Extract

Quantitative Trait Loci (QTLs) are chromosomal regions containing genes causing variation in continuous traits. Two alleles are Identical-By-Descent (IBD) if they are copies of the same original allele. For each point on a chromosome, it is possible to predict IBD probabilities among individuals given a pedigree and marker information and use them to map QTLs in farmed species. Pedigree founders can either be assumed unrelated (George et al. 2000) or related through distant common ancestors (Meuwissen and Goddard 2000). The relationship among founders was estimated through simulating the history of a model population. Linking the current population with original ancestors, without a pedigree, is central to the theory of long-term genetic contributions (Bijma 2000). Hence, in the light of this theory, it should be possible to deterministically predict IBD relationships among pedigree founders. A first step towards this objective was predicting inbreeding (F) within each animal at a chromosomal location.

Copyright

References

Hide All
Bijma, P. (2000) “Long-term genetic contributions: prediction of rates of inbreeding and genetic gain in selected populations” Ph. D. Thesis, Dept. of Animal Sciences, Wageningen, The Netherlands
George, A. W., Visscher, P. M. and Haley, C. S. (2000) “Mapping Quantitative Trait Loci in complex pedigrees: a two-step variance component approachGenetics 156: 20812092
Meuwissen, T. H. E. and GoddardM, E. (2000) “Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker lociGenetics 155: 421430

Predicting inbreeding using markers and long-term genetic contributions

  • J. Hernandez-Sanchez (a1), C. S. Haley (a1) and J. A. Woolliams (a1)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed