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Peptide uptake from the gastrointestinal tract of sheep

Published online by Cambridge University Press:  21 November 2017

M. R. Hipólito-Reis ,
J. C. MacRae  and
F. R. C. Backwell
M. R. Hipólito-Reis
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J. C. MacRae
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
F. R. C. Backwell
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Extract

It is known that uptake of di- and tripeptides by distinct peptide transport systems is an important biological process by which amino acids are absorbed from the gastrointestinal tract (Rubino et al 1971; Webb and Bergman, 1991). However, until recently it was generally accepted that absorbed peptides had to be completely hydrolysed in to free amino acids within the enterocyte (Krzysik and Adibi, 1977) prior to their transport into the circulation. Nevertheless, it has been suggested that, in ruminant species at least, a substantial proportion of the total amino acid uptake from the gastrointestinal tract may be in the form of peptides (Webb, 1990; Seal and Parker, 1991; Webb and Bergman, 1991) and that a large part of this absorption may occur across the stomach region (i.e. rumen and omasum) (Webb, 1990). Consequently, the present study was designed to assess the uptake of amino acids in the form of low molecular weight peptides across the gastrointestinal tract of growing lambs.

Type
Ruminant Nutrition and Digestion
Information
Proceedings of the British Society of Animal Production (1972) , Volume 1994 , March 1994 , pp. 95
Copyright
Copyright © The British Society of Animal Production 1994

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References

Krzysik, B. A., and Adibi, S. A., (1977): “Cytoplasmic dpeptidase activities of kidney, ileum, jejunum, liver, muscle, and blood”; Am. J. Physiol., 233, E450–E456 Google Scholar
Rubino, A., et al (1971): “Intestinal transport of amino acid residues of dipeptides. 1. influx of the glycine residue of gtycyl-L-proline across mucosal border”; J. Biol. Chem., 246 (11), 3542–3548 Google Scholar
Seal, C. J., and Parker, D. S., (1991): “Isolation and characterisation of circulating low molecular weight peptides in steer, sheep, and rat portal and peripheral blood”; Comp. Biochem. Physiol., 00B (0), 000–000 Google Scholar
Webb, K. E., (1990): “Intestinal absorption of protein hydrolysis products: a review”; J. Anim. Sci., 68, 301–3022 CrossRefGoogle ScholarPubMed
Webb, K. E., and Bergman, E. N., (1991): “Amino acid and peptide absorption and transport across the intestine”, Physiological Aspects of Digestion and Metabolism of Ruminants: Proceedings of the Seven International Symposium on Ruminant Physiology.Google Scholar