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The effect of inclusion of virginiamycin in feed on glucose and alanine transport by intestinal brush border membrane vesicles of sheep

Published online by Cambridge University Press:  24 November 2017

D.S. Parker ,
H. Tapper ,
H. Mason  and
H. Tuer
D.S. Parker
Affiliation:
Department of Agricultural Biochemistry and NutritionUniversity of Newcastle upon Tyne Newcastle upon Tyne, NE1 7RU
H. Tapper
Affiliation:
Department of Agricultural Biochemistry and NutritionUniversity of Newcastle upon Tyne Newcastle upon Tyne, NE1 7RU
H. Mason
Affiliation:
Department of Agricultural Biochemistry and NutritionUniversity of Newcastle upon Tyne Newcastle upon Tyne, NE1 7RU
H. Tuer
Affiliation:
Department of Agricultural Biochemistry and NutritionUniversity of Newcastle upon Tyne Newcastle upon Tyne, NE1 7RU
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Extract

Manipulation of the bacterial population of the intestine has been shown to result in changes in the structure and function of mucosal tissues. The objective of the present experiment was to investigate the effect of inclusion of a non-therapeutic antibiotic, virginiamycin, in the diet of sheep on the activity of the Na* -dependant transport of glucose and alanine by enterocyte cells. These transport mechanisms can be studied by isolation of brush border membrane vesicles following sub-cellular fractionation of the mucosal tissues.

Tissue was obtained from two separate growth trials in which the effect of inclusion of virginiamycin on lamb growth was being studied. In Trial 1 (glucose studies) the animals had been fed a concentrate diet plus hay ad libitum and virginiamycin was included at 100 ppm in the treatment group. In Trial 2 (alanine studies) the sheep were fed a concentrate diet with virginiamycin included at 50 ppm in the treatment group.

Type
Ruminant Nutrition
Information
Proceedings of the British Society of Animal Production (1972) , Volume 1990 , March 1990 , pp. 108
Copyright
Copyright © The British Society of Animal Production 1990

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