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Introduction to Fluorocarbons

Published online by Cambridge University Press:  28 June 2012

W. Erdmann
Affiliation:
Department of Anesthesia, Erasmus University, Rotterdam, The Netherlands.
N.S. Faithfull
Affiliation:
Department of Anesthesia, Erasmus University, Rotterdam, The Netherlands.

Extract

Fluorocarbons, which strictly speaking should perhaps be termed perfluorocarbons or perfluorochemicals (PFCs), are organic compounds produced by extensive fluorination of relatively simple alphatic and aromatic chemicals. They have, over the last thirty or forty years, been used for a wide variety of purposes in both industrial and domestic fields. As a consequence of one of their physical properties, namely their high solubility for respiratory gases, they are being developed as constituents of oxygen transporting plasma substitutes. Preliminary trials are being carried out in Japan and the United States and PFCs may well be on the verge of entering routine clinical medicine.

Type
Clinical Topics
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1987

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References

1.Abel, WG. Blood substitute oxygen carriers. N York State J Med 1982; 82:14291433.Google ScholarPubMed
2.Clark, LC and Gollan, F. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science 1966; 152: 17551756.CrossRefGoogle ScholarPubMed
3.Clark, LC, Kaplan, S, Becattini, F. The physiology of artificial blood. J Thorac Cardiovasc Surg 1970; 60:757773.CrossRefGoogle Scholar
4.Clark, LC, Wesseler, EP, Kaplan, S, Miller, ML, Becker, C, Emory, C, Stanley, L, Becattini, F and Obrock, V. Emulsions of perfluorinated solvents for intravascular gas transport. Fed Proc 1975; 34:14681477.Google ScholarPubMed
5.Delpuech, JJ, Hamza, MA and Serratrice, G. Determination of oxygen by a nuclear magnetic resonance method. J Mag Res 1979; 36:173179.Google Scholar
6.Dixon, DE and Holland, DG. Fluorocarbons: properties and synthesis. Fed Proc 1975; 29:14441448.Google Scholar
7.Forman, MB, Bingham, S, Kopelman, HA, Wehr, C, Sandler, MP, Kolodgie, F, Vaughn, WK, Friesinger, GC and Virmani, R. Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion. Circulation 1985; 71:10601068.CrossRefGoogle Scholar
8.Geyer, RP, Monroe, RG and Taylor, K. Survival of rats totally perfused with a fluorocarbon-detergent preparation. In: Organ Perfusion and Preservation. Norman, JC, Folkman, J, Harrison, WG et al (Eds). Appleton-Century-Crofts. New York 1968. pp 8596.Google Scholar
9.Geyer, RP. Fluorocarbon-polyol artificial blood substitutes. New Eng J Med 1973; 289:10771082.Google Scholar
10.Geyer, RP. Recent development in research with perfluorochemical artificial blood substitutes. In: Oxygen carrying colloidal blood substitutes. Frey, R, Beisbarth, H and Stosseck, K. (Eds.) W. Zuckschwerdt Verlag. Munich 1982, pp 1929.Google Scholar
11.Gollan, F and Clark, LC. Organ perfusion with fluorocarbon fluid. The Physiologist 1966; 9:191.Google Scholar
12.Hamza, H, Oda, Y and Nagasawa, S. Solute-solvent interactions in perfluorocarbon solutions of oxygen. J Am Chem Soc 1981; 103:37333738.CrossRefGoogle Scholar
13.Howlett, S, Dundas, D and Sabiston, D. Fluid fluorocarbon as oxygenator in experimental extracorporeal circulation. Arch Surg 1965; 91:643654.Google Scholar
14.Lawson, DD, Moacanin, J, Schrer, KV, Terranova, TF and Ingham, JD. Methods for the estimation of vapour pressures and oxygen solubilities of fluorochemicals for possible application in artificial blood formulations. J Fluorine Chem 1978; 12:221236.CrossRefGoogle Scholar
15.LeBlanc, M and Reiss, JG. Artificial blood substitutes based on perfluorochemicals. In: Preparation, properties, and industrial applications of organofluorine compounds. Ellis Horwood Ltd, Chichester 1982. pp 83138.Google Scholar
16.Long, DM. Fluorocarbons and synthetic bloods: capabilities and future uses. In: Pathophysiology and techniques of cardiopulmonary bypass. Vol. 1. Utley, J.R. (Ed). Williams and Wilkins. Baltimore/London 1982. pp 1223.Google Scholar
17.Miller, ML, Stinnett, JD and Clark, LC JrUltrastructure of tumoricidal peritoneal exudate cells stimulated in vivo by perfluorochemical emulsions. J Reticuloendothel Soc 1980; 27:105118.Google ScholarPubMed
18.Moore, RE and Clarke, LC. Synthesis and physical properties of perfluorocompounds useful as synthetic blood candidates. In: Oxygen carrying colloidal blood substitutes. Frey, R, Beisbarth, H and Stosseck, K. (Eds.) W. Zuckschwerdt Verlag, Munich 1983. pp 5060.Google Scholar
19.Naito, R and Yokoyama, K. Perfluorochemical blood substitutes. Technical Information Ser No 5. Green Cross Corporation, Osaka. 1978.Google Scholar
20.Pfannkuch, F and Schnoy, N. Long-term observation of PFC storage in organs of rats after various dosages. Prog Clin Biol Res 1983; 122:209219.Google ScholarPubMed
21.Reiss, JG. Reassessment of criteria for the selection of perfluorochemicals for 2nd generation blood substitutes: analysis of structure/property relationships. Artif Organs 1984; 8:4455.CrossRefGoogle Scholar
22.Reiss, JG and LeBlanc, M. Solubility and transport phenomena in perfluorochemicals relevant to blood substitution and other biomedical applications. Pure Appl Chem 1982; 54:23832406.Google Scholar
23.Rosenblum, WI, Moncure, W, Behm, G. Some long-term effects of exchange transfusion with fluorocarbon emulsions in macaque monkeys. Arch Pathol Lab Med 1985; 109:340344.Google Scholar
24.Sargent, JW and Seffl, RJ. Properties of perfluorinated liquids. Fed Proc 1970; 29:16991703.Google ScholarPubMed
25.Schmolka, IR. Theory of emulsions. Fed Proc 1970; 29:17171720.Google Scholar
26.Sloviter, HA and Kamimoto, T. Erythrocyte substitute for perfusion of the brain. Nature 1967; 216:458460.Google Scholar
27.Sloviter, HA and Mukherji, B. Emulsions of perfluorochemicals as blood substitutes. Acta Anaesth Belg 1984; 35:6168.Google Scholar
28.Sloviter, HA. Comments during discussion. Prog Clin Biol Res 1983; 122:235236.Google Scholar
29.Suyama, T, Watanabe, M, Hanada, S, Yano, K, Yokoyama, K and Naito, R. Pharmacological analysis of the mode of transient hypotensive action of Fluosol-DA found in the dog. Proc IV Intern Symposium on PFC blood substitutes. Excerpta Medica, Amsterdam 1979. pp 257266.Google Scholar
30.Virmani, R, Warren, D, Rees, R, Fink, LM and English, D. Effects of perfluorochemical on phagocytic function of leukocytes. Transfusion 1983; 23:512515.CrossRefGoogle ScholarPubMed
31.Virmani, R, Fink, LM, Gunter, K and English, D. Effect of perfluorochemical blood substitutes on human neutrophil function. Transfusion 1984; 24:343347.Google Scholar
32.Wickham, NWR and Hardy, NR. Artificial blood from fluorocarbons. Hospital Update 1982; pp 14331444.Google Scholar
33.Yokoyama, K, Yamanouchi, K and Murashima, R. Excretion of perfluorochemicals after intravenous injection of their emulsion. Chem Pharm Bull (Tokyo) 1975; 23:13681373.CrossRefGoogle ScholarPubMed
34.Yokoyama, K, Yamanouchi, K, Arimura, H and Naito, R. Further studies on the fate of perfluorochemicals of Fluosol-DA in animals following intravenous injection. In: Research on perfluorochemicals in medicine and biology. Novakova, V and Plantin, L-O (Eds). Huddinge, Sweden, 1978; pp. 311331.Google Scholar