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Diffuse Cutaneous Allergic Reaction to Dermabond

  • Joseph A. Ricci (a1), Nirav N. Parekh (a2) and Naman S. Desai (a3)


Wound closure with 2-octyl cyanoacrylate (Dermabond; Ethicon, Somerville, New Jersey USA) has recently increased in popularity across a wide spectrum of physicians ranging from surgeons to emergency medicine practitioners. Generally, very few complications are associated with Dermabond and are usually related to application techniques. Uncommonly, patients present with allergic reactions to the adhesive compounds; these allergies are often misdiagnosed as cellulitis or another infectious process, and are incorrectly treated. This report describes a rare case of a diffuse cutaneous allergic reaction to Dermabond following its use to close a surgical incision, its prompt identification, and treatment after presentation to an emergency department.

RicciJA, ParekhNN, DesaiNS. Diffuse Cutaneous Allergic Reaction to Dermabond. Prehosp Disaster Med. 2014;29(5):1-3.


Corresponding author

Correspondence: Joseph A. Ricci, MD Division of Plastic Surgery Brigham and Women's Hospital 75 Francis Street Boston, Massachusetts 02115 USA E-mail


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1.Perry, AW, Sosin, M. Severe allergic reaction to Dermabond. Aesthet Surg J. 2009;29(4):314-316.
2.Nipshagen, MD, Hage, JJ, Beekman, WH. Use of 2-octyl-cyanoacrylate skin adhesive (Dermabond) for wound closure following reduction mammaplasty: a prospective, randomized intervention study. Plast Reconstr Surg. 2008;122(1):10-18.
3.Handschel, JG, Depprich, RA, Dirksen, D, Runte, C, Zimmermann, A, Kubler, NR. A prospective comparison of octyl-2-cyanoacrylate and suture in standardized facial wounds. Int J Oral Maxillofac Surg. 2006;35(4):318-323.
4. US Food and Drug Administration. FDA summary memo: General and Plastic Surgery Devices Advisory Committee (Panel) Meeting, August 25, 2006. Accessed April 16, 2014.
5.El-Dars, LD, Chaudhury, W, Hughes, TM, Stone, NM. Allergic contact dermatitis to Dermabond after orthopaedic joint replacement. Contact Dermatitis. 2010;62(5):315-317.
6.Sachse, MM, Junghans, T, Rose, C, Wagner, G. Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate. Contact Dermatitis. 2013;68(5):317-319.
7.Hivnor, CM, Hudkins, ML. Allergic contact dermatitis after postsurgical repair with 2-octylcyanoacrylate. Arch Dermatol. 2008;144(6):814-815.
8.Dragu, A, Unglaub, F, Schwarz, S, et al. Foreign body reaction after usage of tissue adhesives for skin closure: a case report and review of the literature. Arch Orthop Trauma Surg. 2009;129(2):167-169.
9.Kanerva, L, Jolanki, R, Estlander, T. 10 years of patch testing with the (meth)acrylate series. Contact Dermatitis. 1997;37(6):255-258.
10.Tomb, RR, Lepoittevin, JP, Durepaire, F, Grosshans, E. Ectopic contact dermatitis from ethyl cyanoacrylate instant adhesives. Contact Dermatitis. 1993;28(4):206-208.
11.Belsito, DV. Contact dermatitis to ethyl-cyanoacrylate-containing glue. Contact Dermatitis. 1987;17(4):234-236.


Diffuse Cutaneous Allergic Reaction to Dermabond

  • Joseph A. Ricci (a1), Nirav N. Parekh (a2) and Naman S. Desai (a3)


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