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X-ray powder diffraction data for letrozole (C17H11N5)

  • Yan Mei Huang (a1), Hong Qin Yang (a1), Shou Jun Zheng (a1), Pei Xiao Tang (a1) and Hui Li (a1)...

Abstract

X-ray powder diffraction data, unit-cell parameters, and space group for letrozole, C17H11N5, are reported [a = 7.034(0) Å, b = 16.177(5) Å, c = 13.411(3) Å, α = γ = 90°, β = 105.71(9)°, unit-cell volume V = 1469.0(3) Å3, Z = 4, and space-group P21/c]. All measured lines were indexed and are consistent with the P21/c space group. No detectable impurity was observed.

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a) Author to whom correspondence should be addressed. Electronic mail: lihuilab@sina.com

References

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Cohen, M. H., Johnson, J. R., Li, N., Chen, G., and Pazdur, R. (2002). “Approval summary letrozole in the treatment of postmenopausal women with advanced breast cancer,” Clin. Cancer Res. 8, 665669.
Geisler, J., Helle, H., Ekse, D., Duong, N. K., Evans, D. B., Nordbø, Y., Aas, T., and Lønning, P. E. (2008). “Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels,” Clin. Cancer Res. 14, 63306335.
Harris, K. D. M. (2012). “Powder diffraction crystallography of molecular solids,” Top. Curr. Chem. 315, 133178.
Pan, Q. Q., Guo, P., Duan, J., Cheng, Q., and Li, H. (2012). “Comparative crystal structure determination of griseofulvin: powder X-ray diffraction versus single-crystal X-ray diffraction,” Chin. Sci. Bull. 57, 38673871.
Wang, J., Bei, F. L., Li, R. Y., Yang, X. J., and Wang, X. (2004). “Synthesis, characterization and single crystal structure of 4,4′-(1H-1,2,4triazol-1-methylene) -bisbenzonitrile,” Youji Huaxue 24, 550553.
Xu, X. Y., Ma, W. X., Wang, J., Chen, H. H., Yang, X. J., and Wang, X. (2002). “Crystal structure of 4,4′-(1-H-1,2,4-triazol-1-ylmethylene)bis(benzonitrile),” Huaihai Gongxueyuan Xuebao 11, 3033.

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X-ray powder diffraction data for letrozole (C17H11N5)

  • Yan Mei Huang (a1), Hong Qin Yang (a1), Shou Jun Zheng (a1), Pei Xiao Tang (a1) and Hui Li (a1)...

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