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X-ray powder diffraction analysis of imipenem monohydrate

  • F. Needham (a1), C. E. Crowder (a1), J. W. Reid (a1), T. G. Fawcett (a1) and J. Faber (a1)...

Abstract

An experimental X-ray powder diffraction pattern was produced and analyzed for imipenem monohydrate, an antimicrobial pharmaceutical agent. Although there are no experimental powder patterns in the ICDD PDF-4/Organics Database, there is one powder pattern calculated with single-crystal X-ray diffraction data from the Cambridge Structural Database. Here, we report the refined experimental powder diffraction data for imipenem monohydrate. These data for imipenem monohydrate are consistent with an orthorhombic crystal system having reduced unit-cell parameters of a = 8.2534(3) Å, b = 11.1293(4) Å, and c = 15.4609(6) Å. The resulting unit-cell volume, 1420.15(15) Å3, indicates four formula units per unit cell. Observed peaks are consistent with the P212121 space group.

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Corresponding author

a)Author to whom correspondence should be addressed. Electronic mail: needham@icdd.com

References

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ICDD (2011). PDF-4/Organics 2012 Database, edited by Kabekkodu, S., International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA.
Needham, F., Faber, J., and Fawcett, T. (2006). “X-ray powder diffraction analysis of tegafur,” Powder Diffr. J. 21(3), 245247.
Needham, F. and Faber, J. (2003). “Total pattern analysis using the new organic powder diffraction file: PDF-4/Organics,” Am. Pharm. Rev. 6(4), 1012.
PANalytical (2011). HighScore Plus, Version 3.0.3 (Computer Software), PANalytical, Netherlands.
Ratcliffe, R., Wildonger, K., Michele, L., Douglas, A., Hajdu, R., Goegelman, R., Springer, J., and Hirshfield, J. (1989). “Studies on the structures of imipenem, dehydropeptidase I hydrolyzed imipenem, and related analogues,” J. Org. Chem. 54, 653660.
Sagnella, D. (2011). SQLAids (Computer Software), International Centre for Diffraction Data, Newtown Square, Pennsylvania, USA.
Von Dreele, R. and Larson, A. (2001). General Structure Analysis System (GSAS, Computer Software), University of California, USA.
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Powder Diffraction
  • ISSN: 0885-7156
  • EISSN: 1945-7413
  • URL: /core/journals/powder-diffraction
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