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Crystal structure of methylprednisolone acetate form II, C24H32O6

  • Austin M. Wheatley (a1), James A. Kaduk (a1) (a2), Amy M. Gindhart (a3) and Thomas N. Blanton (a3)

Abstract

The crystal structure of methylprednisolone acetate form II, C24H32O6, has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques. Methylprednisolone acetate crystallizes in space group P212121 (#19) with a = 8.17608(2), b = 9.67944(3), c = 26.35176(6) Å, V = 2085.474(6) Å3, and Z = 4. Both hydroxyl groups act as hydrogen bond donors, resulting in a two-dimensional hydrogen bond network in the ab plane. C–H⋯O hydrogen bonds also contribute to the crystal energy. The powder pattern is included in the Powder Diffraction File™ as entry 00-065-1412.

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a) Author to whom correspondence should be addressed. Electronic mail: kaduk@polycrystallography.com

References

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Crystal structure of methylprednisolone acetate form II, C24H32O6

  • Austin M. Wheatley (a1), James A. Kaduk (a1) (a2), Amy M. Gindhart (a3) and Thomas N. Blanton (a3)

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