Let me begin by thanking editor Jeff Isaac for inspiring and bringing to fruition this exchange. Securing the participation of nine academics and then cajoling us to meet deadlines and follow instructions is a remarkable accomplishment and I can only hope the finished product approaches his hopes for the enterprise. I would also like to thank the eight scholars who provided commentaries on my target essay. I am truly fortunate that such an all-star cast was willing to spend time pondering the role of neurobiology and politics. They assisted me in better understanding my own positions, and who can ask for more than that? I do not have the space here to offer the point-by-point response that their comments deserve, so I will instead concentrate on the two concerns that were raised most frequently: first, whether biological approaches can answer the kinds of questions political scientists should be asking, and second, whether, regardless of their value in answering questions, applying biological techniques to social behaviors leads to normatively unpalatable conclusions. Before addressing these two important matters, however, it is worth a moment to mention several areas of agreement.