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Novel Investigations of the Connection between Quantitative Personality-Psychopathology Models and Neuroscience

Guest Editors: Robert D. Latzman, Giorgia Michelini, Colin G. DeYoung, and Robert F. Krueger

Clinical neuroscience aims to elucidate neural correlates of mental illness and translate that knowledge into effective biologically informed interventions. There has been a growing consensus, however, that the lack of progress to date may be a result of the well-documented shortcomings of the categorical diagnostic system; the categorical system is scientifically untenable. Indeed, a large and reliable empirical literature has demonstrated the superiority of quantitatively-derived dimensional models of classification, including, for example, the Hierarchical Taxonomy of Psychopathology (HiTOP). Importantly, it has become clear that these models converge with quantitative models of personality, typically reflecting the same latent dimensions in both the general and maladaptive ranges. The field has thus come to realize that the convergence of models of personality and psychopathology represents a promising phenotypic target for neurobiological investigations of psychopathology and related processes. This special issue of Personality Neuroscience will focus on the connection of quantitative models that integrate personality and psychopathology with neuroscientific inquiry. The overarching goal of this special issue will be to highlight sophisticated novel research aimed at elucidating neurobiological correlates of broad, transdiagnostic processes within an integrated personality-psychopathology framework.

Empirical Paper

Review Paper