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Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel

  • M. K. Shaw (a1) and D. A. Erasmus (a1)

Summary

The long-term, in vivo effects of a single, subcurative dose (200 mg/kg body weight of mouse) of praziquantel on the structure of adult Schistosoma mansoni and on the process and speed of tegumental repair are described. In both male and female worms praziquantel caused often extensive damage to the tegument, in the form of surface blebbings, swellings and lesions, and vacuolization and disruption of the subtegumental tissues. Repair of the drug-induced tegumental damage occurred slowly with partial and, more rarely, complete repair only being seen after 65 days post-treatment (p.t.), although signs of damage were still observed, particularly in male worms, at 100 days p.t. In contrast, repair of damage to the subtegumental/parenchymal tissues including the tegumental perikarya occurred relatively quickly, with the majority of worms examined appearing normal by 8–12 days p.t. The possible role(s) of the host immune response in relation to the speed of tegumental repair in vivo is discussed.

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Andrews, P. (1978). Effects of praziquantel on the metabolism of Schistosoma mansoni. Fourth International Congress of Parasitology, Warsaw. Section D, 5–6.
Andrews, P. (1981). A summary of the efficacy of praziquantel against schistosomes in animal experiments and notes on its mode of action. Arzneimittel-Forschung/Drug Research 31, 538–41.
Andrews, P., Thomas, H. & Weber, H. (1980). The in vitro uptake of 14C-praziquantel by cestodes, trematodes and a nematode. Journal of Parasitology 66, 920–5.
Becker, B., Mehlhorn, H., Andrews, P., Thomas, H. & Eckert, J. (1980). Light and electron microscopic studies on the effects of praziquantel on Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica (Trematoda) in vitro. Zeitschrift für Parasitenkunde 63, 113–28.
Bentley, A. G. (1982). Tegumental repair in the adult trematode Ochetosoma aniarum. Journal of Parasitology 68, 10961104.
Carlisle, S., Weisberg, L. S. & Bentley, A. G. (1983). Schistosoma mansoni: Morphologic changes induced by maintenance in vitro. Journal of Parasitology 69, 319–34.
Coles, G. C. (1984). Recent advances in schistosome biochemistry. Parasitology 89, 603–37.
Doenhoff, M. J. & Bain, J. (1978). The immune-dependence of schistosomicidal chemotherapy: Relative lack of efficacy of an antimonal in Schistosoma mansoni-infected mice deprived of their T-cells and the demonstration of drug-antiserum synergy. Clinical and Experimental Immunology 33, 232–8.
Duvall, R. H. & Dewitt, W. B. (1967). An improved perfusion technique for recovering adult schistosomes from laboratory animals. American Journal of Tropical Medicine and Hygiene 16, 483–6.
Hockley, D. J. (1973). Ultrastructure of the tegument of Schistosoma. Advances in Parasitology 11, 233305.
Kusel, J. R. & Mackenzie, P. E. (1975). The measurement of the relative turnover rates of proteins of the surface membranes and other fractions of Schistosoma mansoni in culture. Parasitology 71, 261–73.
Leitch, B. & Probert, A. J. (1984). Schistosoma haematobium: Amoscanate and adult worm ultrastructure. Experimental Parasitology 58, 278–89.
McLaren, D. J. (1980). Schistosoma mansoni: The parasite surface in relation to host immunity. In Tropical Medicine Research Studies 1. Chichester: Research Studies Press, John Wiley Press.
Mehlhorn, H., Becker, B., Andrews, P., Thomas, H. & Frenkel, J. K. (1981). In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni. Arzneimittel-Forschung/Drug Research 31, 544–54.
Mehlhorn, H., Frenkel, J. K., Andrews, P. & Thomas, H. (1982). Light and electron microscopic studies on Schistosoma mansoni granulomas of mice livers following treatment with praziquantel. Tropenmedizin und Parasitologie 33, 229–39.
Perez, H. & Terry, R. J. (1973). The killing of adult Schistosoma mansoni in vitro in the presence of antisera to host antigenic determinants and peritoneal cells. International Journal for Parasitology 3, 499503.
Philipp, M. & Rumjanek, F. D. (1984). Antigenic and dynamic properties of helminth surface structures. Molecular and Biochemical Parasitology 10, 245–68.
Popiel, I. & Erasmus, D. A. (1984). Schistosoma mansoni: Ultrastructure of adults from mice treated with oxamniquine. Experimental Parasitology 58, 254–62.
Popiel, I., Irving, D. L. & Basch, P. F. (1985). Wound healing in the trematode Schistosoma. Tissue and Cell 17, 6977.
Sabah, A. A., Fletcher, C., Webbe, G. & Doenhoff, M. J. (1985). Schistosoma mansoni: Reduced efficacy of chemotherapy in infected T-cell-deprived mice. Experimental Parasitology 60, 348–54.
Shaw, M. K. & Erasmus, D. A. (1983 a). Schistosoma mansoni: The effects of a subcurative dose of praziquantel on the ultrastructure of worms in vivo. Zeitschrift für Parasitenkunde 69, 7390.
Shaw, M. K. & Erasmus, D. A. (1983 b). Schistosoma mansoni: Dose-related tegumental surface changes after in vivo treatment with praziquantel. Zeitschrift für Parasitenkunde 69, 643–53.
Simpson, A. J. G. & McLaren, D. J. (1982). Schistosoma mansoni: Tegumental damage as a consequence of lectin binding. Experimental Parasitology 53, 105–16.
Smithers, S. R. & Terry, R. J. (1965). Infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695700.
Standen, O. D. (1962). Observations in mice on the schistosomicidal properties of 1,7–bis (p–aminophenoxy) heptane in vivo and in vivo/in vitro. Ciba Foundation Symposium: Bilharziasis (ed. Wolstenholme, G. E. W. and M., O'Connor), London: pp. 266–86. J. & A. Churchill Ltd.
Voge, M. & Bueding, E. (1980). Schistosoma mansoni: Tegumental surface alterations induced by subcurative doses of the schistosomicide amoscanate. Experimental Parasitology 50, 251–9.
Wilson, R. A. & Barnes, P. E. (1974). An in vitro investigation of dynamic processes occurring in the schistosome tegument, using compounds known to disrupt secretory processes. Parasitology 68, 259–70.
Wilson, R. A. & Barnes, P. F. (1977). The formation and turnover of the membranocalyx of the tegument of Schistosoma mansoni. Parasitology 74, 6171.

Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel

  • M. K. Shaw (a1) and D. A. Erasmus (a1)

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