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Membrane fluidity on the surface of Hymenolepis diminuta (Cestoda): immunological implications

  • K. TAYLOR (a1), J. R. KUSEL (a2) and D. HOOLE (a3)

Abstract

Regional differences of Hymenolepis diminuta to immune lysis have been investigated by monitoring surface membrane fluidity utilizing fluorescence recovery after photobleaching (FRAP). Although the surface membrane of the newly excysted stage was completely immobile the molecular fluidity of the strobila membrane of 4-day-old parasites was greater than that associated with the scolex/neck region. Significant differences (P>0·001) occurred in the mobility of the strobila membrane of 4-day-old H. diminuta from 100-worm infections compared with 7- and 21-day-old parasites and 4-day-old individuals from 10-worm infections. Exposure to 50% normal rat serum and 1 mg/ml rat C reactive protein decreased or eliminated membrane fluidity. The significance of membrane mobility is discussed with reference to resistance to complement-mediated lysis and destrobilation.

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Corresponding author

Corresponding author: Centre for Applied Entomology and Parasitology, Department of Biological Sciences, Keele University, Keele, Staffs ST5 5BG, UK. Tel: +01782 583673. Fax: +01782 583516. E-mail: bia10@keele.ac.uk

Keywords

Membrane fluidity on the surface of Hymenolepis diminuta (Cestoda): immunological implications

  • K. TAYLOR (a1), J. R. KUSEL (a2) and D. HOOLE (a3)

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