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Impact of Nippostrongylus brasiliensis (Nematoda) on the serum albumin and amino acid concentrations of rats fed adequate or protein-deficient diets

Published online by Cambridge University Press:  06 April 2009

Caroline Ash ,
D. W. T. Crompton  and
P. G. Lunn
Caroline Ash
Affiliation:
Department of Parasitology, Molteno Institute, University of Cambridge, Downing Street, Cambridge CB2 3EE
D. W. T. Crompton
Affiliation:
Department of Parasitology, Molteno Institute, University of Cambridge, Downing Street, Cambridge CB2 3EE
P. G. Lunn
Affiliation:
Medical Research Council, Dunn Nutritional Laboratory, Milton Road, Cambridge CB4 1XJ
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Extract

Food intake, body weight changes, serum protein and amino acid concentrations were measured during the course of primary infections of Nippostrongylus brasiliensis in rats fed on either a 2% protein (casein) diet or a 16% protein diet (Oxoid 41 B). Total serum protein concentration declined from 77·84±5·35 mg/ml in uninfected well-nourished rats to 54±3·29 mg/ml in rats at 9 days post-infection (p.i.). A reduction from 47·80±2·78 to 40·38±5·62 mg/ml had occurred in protein-malnourished rats by day 6 p.i. The hypoproteinaemia was accompanied by significant hypoalbuminaemia in the protein-malnourished rats and concentrations fell from approximately 33 to 19 mg/ml at the time of peak infection. Six days after inoculation, a significant increase was detected in the concentration of serum amino acids in both well-nourished and protein-malnourished rats; the effect was more prolonged for non-essential than for essential amino acids. The results are discussed briefly in relation to recent work on the control of protein metabolism during malnutrition.

Type
Research Article
Information
Parasitology , Volume 90 , Issue 1 , February 1985 , pp. 157 - 168
Copyright
Copyright © Cambridge University Press 1985

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