Skip to main content Accessibility help
×
Home

Further evaluation of the synthetic peptide vaccine S3Pvac against Taenia solium cysticercosis in pigs in an endemic town of Mexico

  • E. SCIUTTO (a1), J. MORALES (a2), J. J. MARTÍNEZ (a2), A. TOLEDO (a1), M. N. VILLALOBOS (a2), C. CRUZ-REVILLA (a1), G. MENESES (a1), M. HERNÁNDEZ (a1), A. DÍAZ (a3), L. F. RODARTE (a2), G. ACERO (a1), G. GEVORKIAN (a1), K. MANOUTCHARIAN (a1), J. PANIAGUA (a4), G. FRAGOSO (a1), A. FLEURY (a5), R. LARRALDE (a1), A. S. DE ALUJA (a2) and C. LARRALDE (a1)...

Abstract

Taenia solium cysticercosis is a parasitic disease frequently affecting human health and the pig industry in many developing countries. A synthetic peptide vaccine (designated S3Pvac) against porcine cysticercosis has been developed previously as an aid to interrupt transmission and has been shown to be effective. The results of the present study support the effectiveness of the vaccine under endemic field conditions. However, given the time-frame of the vaccination trial, no changes in the local levels of transmission were detectable before and after vaccination using sentinel pigs. Thus, this investigation shows the limited usefulness of single vaccination as the sole means of interrupting Taenia solium transmission in an endemic region.

Copyright

Corresponding author

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, Ciudad Universitaria, 04510 México, D.F. México. Tel: +5255 5622 3153. Fax: +5255 5622 3369. E-mail: edda@servidor.unam.mx

References

Hide All

REFERENCES

Boa, M., Mukaratirwa, S., Willingham, A. L. and Johansen, M. V. ( 2003). Regional action plan for combating Taenia solium cysticercosis/taeniosis in Eastern and Southern Africa. Acta Tropica 87, 183186.
Cabrera, P. A., Lloyd, S., Haran, G., Pineyro, L., Parietti, S., Gemmell, M. A., Correa, O., Morana, A. and Valledor, S. ( 2002). Control of Echinococcus granulosus in Uruguay: evaluation of different treatment intervals for dogs. Veterinary Parasitology 103, 333340. DOI: 10.1016/S0304-4017(01)00603-3.
Cai, X., Chai, Z., Jing, Z., Wang, P., Luo, X., Chen, J., Dou, Y., Feng, S., Su, C. and Jin, J. ( 2001). Studies on the development of DNA vaccine against Cysticercus cellulosae infection and its efficacy. The Southeast Asian Journal of Tropical Medicine and Public Health 32, 105110.
Carabin, H., Krecek, R. C., Cowan, L. D., Michael, L., Foyaca-Sibat, H., Nash, T. and Willingham, A. L. ( 2006). Estimation of the cost of Taenia solium cysticercosis in Eastern Cape Province, South Africa. Tropical Medicine and International Health 11, 906916. DOI: 10.1111/j.1365-3156.2006.01627.
Fleury, A., Morales, J., Bobes, R. J., Dumas, M., Yanez, O., Pina, J., Carrillo-Mezo, R., Martinez, J. J., Fragoso, G., Dessein, A., Larralde, C. and Sciutto, E. ( 2006). An epidemiological study of familial neurocysticercosis in an endemic Mexican community. Transactions of the Royal Society of Tropical Medicine and Hygiene 100, 551558. DOI: 10.1016/j.trstmh.2005.08.008.
Flisser, A., Gauci, C. G., Zoli, A., Martinez-Ocana, J., Garza-Rodriguez, A., Dominguez-Alpizar, J. L., Maravilla, P., Rodriguez-Canul, R., Avila, G., Aguilar-Vega, L., Kyngdon, C., Geerts, S. and Lightowlers, M. W. ( 2004). Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infection and Immunity 72, 52925297. DOI: 10.1128/IAI.72.9.5292-5297.2004.
Gemmell, M. A. ( 1978). The styx field trial: effect of treatment of the definitive host for tapeworms on larval forms in the intermediate host. Bulletin of the World Health Organization 56, 433443.
González, A. E., Cama, V., Gilman, R. H., Tsang, V. C., Pilcher, J. B., Chavera, A., Castro, M., Montenegro, T., Verastegui, M., Miranda, E. and Bazalar, H. ( 1990). Prevalence and comparison of serologic assays, necropsy and tongue examination for the diagnosis of porcine cysticercosis in Peru. American Journal of Tropical Medicine and Hygiene 43, 194199.
González, A. E., Gauci, C. G., Barber, D., Gilman, R. H., Tsang, V. C., Garcia, H. H., Verastegui, M. and Lightowlers, M. W. ( 2005). Vaccination of pigs to control human neurocysticercosis. American Journal of Tropical Medicine and Hygiene 72, 837839.
Huerta, M., De Aluja, A. S., Fragoso, G., Toledo, A., Villalobos, N., Hernández, M., Gevorkian, G., Acero, G., Diaz, A., Alvarez, I., Avila, R., Beltrán, C., Garcia, G., Martínez, J. J., Larralde, C. and Sciutto, E. ( 2001). Synthetic peptide vaccine against Taenia solium pig cysticercosis: successful vaccination in a controlled field trial in rural México. Vaccine 20, 262266. DOI: 10.1016/S0264-410X(01)00249.
Manoutcharian, K., Rosas, G., Hernández, M., Fragoso, G., Aluja, A., Villalobos, N., Rodarte, L. F. and Sciutto, E. ( 1996). Cysticercosis: identification and cloning of protective recombinant antigens. Journal of Parasitology 82, 250254.
Manoutcharian, K., Diaz-Orea, A., Gevorkian, G., Fragoso, G., Acero, G., Gonzalez, E., De Aluja, A., Villalobos, N., Gomez-Conde, E. and Sciutto, E. ( 2004). Recombinant bacteriophage-based multiepitope vaccine against Taenia solium pig cysticercosis. Veterinary Immunology and Immunopathology 99, 1124. DOI: 10.1016/j.vetimm.2003.12.009.
Molinari, J. L., Rodríguez, D., Tato, P., Soto, R., Arechavaleta, F. and Solano, S. ( 1997). Field trial for reducing porcine Taenia solium cysticercosis in Mexico by systematic vaccination of pigs. Veterinary Parasitology 69, 5563.
Morales, J., Velasco, T., Tovar, V., Fragoso, G., Fleury, A., Beltran, C., Villalobos, N., Aluja, A., Rodarte, L. F., Sciutto, E. and Larralde, C. ( 2002). Castration and pregnancy of rural pigs significantly increase the prevalence of naturally acquired Taenia solium cysticercosis. Veterinary Parasitology 1, 4148. DOI: 10.1016/S0304-4017(02)00168-1.
Morales, J. ( 2003). The porciculture and the presence of Taenia solium cysticercosis in an indigenous community of Morelos, México. Thesis. Facultad de Ciencias Agropecuarias Universidad Autónoma del Estado de Morelos, México.
Nascimento, E., Costa, J. O., Guimaraes, M. P. and Tavares, C. A. ( 1995). Effective immune protection of pigs against cysticercosis. Veterinary Immunology and Immunopathology 45, 127137.
Phiri, I. K., Ngowi, H., Afonso, S., Matenga, E., Boa, F., Mukaratirwa, M. S., Githigia, S., Saimo, M., Sikasunge, C., Maingi, N., Lubega, G. W., Kassuku, A., Michael, L., Siziya, S., Krecek, R. C., Noormahomed, E., Vilhena, M., Dorny, P. and Willingham, A. L. 3rd ( 2003). The emergence of Taenia solium Cysticercosis in Eastern and Southern Africa as a serious agricultural problem and public health risk. Acta Tropica 87, 1323. DOI: 10.1016/S0001-706X(03)00051-2.
Plancarte, A., Flisser, A., Gauci, C. G. and Lightowlers, M. W. ( 1999). Vaccination against Taenia solium cysticercosis in pigs using native and recombinant oncosphere antigens. International Journal for Parasitology 29, 643647. DOI: 10.1016/S0020-7519(99)00021-1.
Sciutto, E., Martinez, J. J., Villalobos, N. M., Hernández, M., Jose, M. V., Beltran, C., Rodarte, F., Flores, I., Bobadilla, J. R., Fragoso, G., Parkhouse, M. E., Harrison, L. J. and De Aluja, A. S. ( 1998). Limitations of current diagnostic procedures for the diagnosis of Taenia solium cysticercosis in rural pigs. Veterinary Parasitology 79, 299313. DOI: 10.1016/S0304-4017(98)00180-0.
Sciutto, E., Fragoso, G., Fleury, A., Laclette, J. P., Sotelo, A. J., Aluja, A., Vargas, L. and Larralde, C. ( 2000). Taenia solium disease in humans and pigs: an ancient parasitosis disease rooted in developing countries and emerging as a major health problem of global dimensions. Microbes and Infection 15, 18751890. DOI: 10.1016/S1286-4579(00)01336-8.
Toledo, A., Larralde, C., Fragoso, G., Gevorkian, G., Manoutcharian, K., Hernández, M., Acero, G., Rosas, G., Lopez-Casillas, F., Garfias, C. K., Vazquez, R., Terrazas, I. and Sciutto, E. ( 1999). Towards a Taenia solium cysticercosis vaccine: an epitope shared by Taenia crassiceps and Taenia solium protects mice against experimental cysticercosis. Infection and Immunity 67, 25222530.
Toledo, A., Fragoso, G., Rosas, G., Hernández, M., Gevorkian, G., Lopez-Casillas, F., Hernández, B., Acero, G., Huerta, M., Larralde, C. and Sciutto, E. ( 2001). Two epitopes shared by Taenia crassiceps and Taenia solium confer protection against murine T. crassiceps cysticercosis along with a prominent T1 response. Infection and Immunity 69, 17661773. DOI: 10.1128/IAI.69.3.1766-1773.2001.
Viljoen, N. F. ( 1937). Cysticercosis in swine and bovines, with special reference to South African conditions. Onderstepoort Journal of Veterinary Science and Animal Industry 9, 337570.
Wang, Q. M., Sun, S. H., Hu, Z. L., Wu, D. and Wang, Z. C. ( 2003). Immune response and protection elicited by DNA immunization against Taenia cysticercosis. Vaccine 21, 16721680. DOI: 10.1016/S0264-410X(02)00661-8.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed