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Effects of CD4+CD25+Foxp3+regulatory T cells on early Plasmodium yoelii 17XL infection in BALB/c mice

  • GUANG CHEN (a1) (a2), JUN LIU (a1), QING-HUI WANG (a1), YI WU (a3), HUI FENG (a1), WEI ZHENG (a1), SHENG-YU GUO (a4), DONG-MEI LI (a5), JI-CHUN WANG (a6) and YA-MING CAO (a1)...


The outcome of Plasmodium yoelii 17XL-infected BALB/c and DBA/2 mice, ranging from death to spontaneous cure, respectively, depends largely on the establishment of effective pro-inflammatory type 1 responses during the early stages of infection and associates with CD4+CD25+Foxp3+regulatory T cells (Tregs). Here, effects of Tregs were analysed on early P. yoelii 17XL infection in BALB/c and DBA/2 mice. In vivo depletion of Tregs significantly reversed the inhibited establishment of effective pro-inflammatory type 1 responses in BALB/c mice, indicating that this cell population contributed to the suppression of T-cell function in malaria. Moreover, the proportion and absolute numbers of IL-10-secreting Tregs in BALB/c mice were significantly higher than that found in DBA/2 mice by intracytoplasmic staining, and IL-10 production was correlated with the Tregs population. In addition, in vivo Tregs depletion decreased the production of IL-10 and the apoptosis of CD4+ T cells. Consistently, IL-10R blockade also had the same effect as that of Tregs depletion in P. yoelii 17XL-infected BALB/c mice. Our data demonstrate that Tregs perhaps have an important role in regulating pro-inflammatory type 1 responses in an IL-10-dependent manner and induce CD4+ T cell apoptosis during the early stage of P. yoelii 17XL infection.


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*Corresponding author: Department of Immunology, College of Basic Medical Sciences, China Medical University, No. 92 Beier Road, Heping District, Shenyang, China. Tel: +86 24 23256666 5346. Fax: +86 24 23264417. E-mail address:


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Effects of CD4+CD25+Foxp3+regulatory T cells on early Plasmodium yoelii 17XL infection in BALB/c mice

  • GUANG CHEN (a1) (a2), JUN LIU (a1), QING-HUI WANG (a1), YI WU (a3), HUI FENG (a1), WEI ZHENG (a1), SHENG-YU GUO (a4), DONG-MEI LI (a5), JI-CHUN WANG (a6) and YA-MING CAO (a1)...


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