Skip to main content Accessibility help

The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

  • S. L. Riley (a1) and J. Chernin (a1)


Three strains of male and female mice, CFLP, BALB/c and CBA/ca, were infected i.p. with the tetrathyridia of Mesocestoides corti and examined in groups of 5 at 0, 7, 14, 21, 28 and 42 days post-infection. At post-mortem the numbers of parasites both loose in the peritoneal cavity and in the liver tissue were counted, the livers weighed fresh and sections of liver stained to examine the inflammatory response, encapsulation of the tetrathyridia and for eosinophils, neutrophils, mast cells and plasma cells. BALB/c mice had significantly more parasites loose in the peritoneal cavity than CFLP and CBA/ca mice. Infected livers of all three strains were significantly heavier than control livers; the heaviest livers were those of the CFLP followed by the CBA/ca mice which also showed the greatest rate of weight increase. The tetrathyridia from the peritoneal cavities of the CBA/ca and CFLP mice were covered with a ‘mucilage-like’ substance. Tetrathyridia within the host capsules of the CBA/ca mice contained host cells. There was no strain difference with regard to numbers of tetrathyridia in the liver but male mice harboured significantly more parasites than females. Differences in the numbers of cell types within the liver were detected between the strains but no one strain showed any consistent pattern. There was an overall increase in total white blood counts as well as an increase in the number of eosinophils, monocytes, neutrophils and lymphocytes during the course of the infection.



Hide All
Chernin, J. & McLaren, D. J. (1983). The pathology induced in laboratory rats by the metacestodes of Taenia crassiceps and Mesocestoides corti (Cestoda). Parasitology 87, 279–87.
Chernin, J., Miller, H. R. P., Newlands, G. F. J. & McLaren, D. J. (1988). Proteinase phenotypes and fixation properties of rat mast cells in parasitic lesions caused by Mesocestoides corti; selective and site specific recruitment of mast cell subsets. Parasite Immunology 10, 433–42.
Cook, R. M., Ashworth, R. F. & Chernin, J. (1988). Cytotoxic activity of rat granulocytes against Mesocestoides corti. Parasite Immunology 10, 97109.
Culling, C. F. A. (1974). Handbook of Histopathological Techniques. 3rd Edn.Trowbridge and Esher: Butterworths.
Disbrey, B. D. & Rack, J. H. (1970). Histological Laboratory Methods. Edinburgh and London: E. & S. Livingston.
Dixon, W. J. (1988). BMDP Statistical Software Manual, Vols 1 and 2. Berkeley, California: University of California Press.
Kowalski, J. C. & Thorenson, R. E. (1972). Protective immunity against tetrathyridia of Mesocestoides corti by passive transfer of serum in mice. Journal of Parasitology 58, 244–6.
Lammas, D. A., Mitchell, L. A. & Wakelin, D. (1990). Genetic influences upon eosinophilia and resistance in mice infected with Mesocestoides corti. Parasitology 101, 291–9.
Letonja, T. & Hammerberg, C. (1987). Taenia taeniaeformis: early inflammatory response around developing metacestodes in the liver of resistant and susceptible mice. I. Identification of leucocyte response with monoclonal antibodies. Journal of Parasitology 73, 962–70.
Mitchell, G. F., Marchalonis, J. J., Smith, P. M., Nicholas, W. L. & Warner, N. L. (1977). Studies on the immune response to larval cestodes in mice: a simple mechanism of non-specific immunosuppression in Mesocestoides corti infected mice. Australian Journal of Experimental Biology and Medical Science 55, 615–22.
Novak, M. (1972). Quantitative studies on the growth and multiplication of tetrathyridia of Mesocestoides corti Heoppli, 1925 (Cestoda: Cyclophyllidea) in rodents. Canadian Journal of Zoology 50, 1189–96.
Pollaco, S., Nicholas, W. L., Mitchell, G. F. & Stewart, A. C. (1978). T-cell dependent collagenous encapsulating response in mouse liver to Mesocestoides corti (Cestoda). International Journal for Parasitology 8, 457–62.
Specht, D. & Widmer, E. A. (1972). Response of mouse liver to infection with tetrathyridia of Mesocestoides (Cestoda). Journal of Parasitology 58, 431–7.
Stryer, L. (1981). Biochemistry, 2nd edn.New York & San Francisco: W. H. Freeman & Co.
Todd, K. S. Jr, Simon, J. & Dipietro, J. A. (1978). Pathological changes in mice infected with tetrathyridia of Mesocestoides corti. Laboratory Animals 12, 51–3.
Voge, M. (1955). North American cestodes of the genus Mesocestoides. University of California Publications in Zoology 59, 125–56.
White, T. R., Thompson, R. C. A. & Penhale, W. J. (1982). A comparative study of inbred strains of mice to infection with Mesocestoides corti. International Journal for Parasitology 12, 2933.


The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

  • S. L. Riley (a1) and J. Chernin (a1)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed