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Biological effects of lithium chloride on the insect trypanosomatid Herpetomonas samuelpessoai

Published online by Cambridge University Press:  06 April 2009

C. V. Nakamura  and
A. S. Pinto
C. V. Nakamura
Affiliation:
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, C.P. 2486, Belo Horizonte, 31270, MG, Brasil
A. S. Pinto
Affiliation:
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, C.P. 2486, Belo Horizonte, 31270, MG, Brasil
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Summary

Effects of lithium chloride on growth, differentiation and respiration of Herpetomonas samuelpessoai, cultivated in a synthetic medium were studied both at 28 and 37 °C. Low concentration of lithium chloride (15 mM) stimulated growth at 37 °C. In addition, the protozoon tolerated high concentrations (60–150 mM) of the salt at both incubation temperatures. In general, 15 mM lithium chloride increased and 150 mM decreased oxygen uptake when glucose, glutamic acid and proline were used as substrates. However, at 28 °C after incubation for 96 h, the highest concentration increased oxygen uptake in the presence of glucose. Sodium butyrate induced cell differentiation in H. samuelpessoai both at 28 and 37 °C. High concentration (150 mM) of lithium chloride inhibited cell differentiation of H. samuelpessoai induced by both controlled growth conditions and butyrate addition. The results obtained are described in this paper.

Keywords

Herpetomonas samuelpessoailithiumrespirationgrowthdifferentiation
Type
Research Article
Information
Parasitology , Volume 99 , Issue 2 , October 1989 , pp. 193 - 197
Copyright
Copyright © Cambridge University Press 1989

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